Sharing the result of a collaboration with Kristin Stanford and team @OhioStateDHLRI: The brown fat–derived lipokine 12,13-diHOME combats age-related heart decline by inhibiting CaMKII and reducing ER stress. doi.org/10.1038/s414... @AdventHealthMD

12,13-diHOME protects against the age-related decline in cardiovascular function via attenuation of CaMKII - Nature Communications

Cardiovascular function declines with age. In this study, the authors show that the BAT-derived lipokine 12,13-diHOME preserves cardiac function in aged mice by attenuating pathological CaMKII activit...

doi.org

The Study of Muscle Mobility and Aging (SOMMA) is open for enrollment!! SOMMA is a prospective, longitudinal cohort study designed to examine the biological properties of skeletal muscle that predict onset of disability or dementia in older adults. Learn more about SOMMA: sommaonline.ucsf.edu

Delighted to share a recent publication from a long standing collaboration with @siobhanmalany.bsky.social, Maddalena Parafati, and their outstanding team at University of Florida. www.cell.com/stem-cell-re... @spacex.extwitter.link @stemcellreports.bsky.social @adventhealth.bsky.social

Microgravity accelerates skeletal muscle degeneration: Functional and transcriptomic insights from an ISS muscle lab-on-chip model

In this article, Parafati, Malany, and colleagues show that microgravity altered contractile response and slow-twitch protein levels in a lab-on-chip muscle model on the ISS. Electrical stimulation en...

cell.com

We are recruiting! We have an open position for a Postdoctoral Fellow with the Aging, Exercise and Bioenergetics group at the Translational Research Institute in Orlando, Florida. If you know of an any trainees who might be interested, please let them know! jobs.adventhealth.com/orlando-fl/r...

Acute myeloid leukemia mitochondria hydrolyze ATP to support oxidative metabolism and resist chemotherapy

Acute myeloid leukemia mitochondria hydrolyze ATP to support oxidative metabolism and resist chemotherapy

Unlike healthy blood cells, AML cells reverse the ATP synthase reaction to support oxidative metabolism and resist chemotherapy.

science.org

WTF! Leadership of the National Institute on Aging was apparently “decimated,” with deputy director Amy Kelly and scientific director Luigi Ferrucci— “one of the brightest luminaries in the world in gerontology,” per a source — among those fired. www.splinter.com/bloodbath-at...

'Bloodbath' at NIH and Elsewhere at HHS Begins

Splinter is your home for news and opinions that challenge power in our political and economic system that's becoming more unhinged each and every day.

splinter.com

Clinical and humans physiology to the fore. Think about submitting your work to The Journal of Physiology. doi.org/10.1113/jp28...

Here comes the sun: the central role of human and clinical physiology in the era of multi‐omics and inter‐organ crosstalk

Click on the article title to read more.

doi.org