Andrea Corbetta

@corbettandrea.bsky.social

PhD Student in Human Technopole, Milan Answers seeker in any data

🧬💥 Do the genetics that make you develop a disease also help you survive it? Not much. Our new study in Nature Genetics including 9 disease and 7 biobanks shows: • Susceptibility variants ≠ survival • PRSs for onset weak at predicting progression • Lifespan PRS predicts survival better

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💥 New preprint & our first RCT! 💥 Does an extremely high or low BMI polygenic score influence weight loss after a diet intervention? GENEROOS is a 6-month randomized diet vs. control trial testing if genetic predisposition to higher BMI affects weight loss in overweight adults

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