Claim to fame … ☺️🙈 our patented work in the @gutmannlab.bsky.social repurposing lamotrigine, a common anti epileptic drug, to treat pediatric gliomas was recognized 🎉.

Wishing you a boo-tiful Halloween from the lab! 🧪🎃 May your experiments work and your candy be plentiful. 👻

Shameless self promotion of our new paper. So very excited to share our new work uncovering coupling of glutamate receptors ⚡️and RTKs to enable growth of low-grade gliomas 🧠 @gutmannlab.bsky.social @washuneurology.bsky.social

Neuron@cp-neuron.bsky.social · 12mo ago

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Aberrant coupling of glutamate and tyrosine kinase receptors enables neuronal control of brain-tumor growth

Anastasaki and colleagues establish a previously unknown glutamate growth dependency in pediatric low-grade brain tumors (gliomas). Glioma cells hijack normal neuron-glial molecular circuits present during neurodevelopment, using aberrant glutamate receptor stimulation to activate PDGFRα/ERK via Src. This uncovers a molecular link between neurotransmitter signaling and tumor growth in children.

dlvr.it

Ready for an amazing visit from Penny’s flight 🦋 🦋

So many proud and bittersweet feels for these two! We have worked with these amazing star students for so many years.. it is hard to say goodbye to family! So for now… see ya later, ladies 🫶🏻🫶🏻🫶🏻 @gutmannlab.bsky.social wishes you the very best Leah, and Hannah xx it was been a privilege xx

Today, we celebrate the journey of two amazing trainees in the lab. They have great things coming into their future, and we are equally sad and proud to see them go. Wherever their paths may take them, the Gutmann lab will always be their home. Good luck, Laura and Xuanwei!

Giving Wednesday @washu Medicine today! All the fun! Come support our Med School!

13 glorious years of working with @corinaanast.bsky.social at @gutmannlab.bsky.social. 🎂

Happy holiday season from all of us in the @gutmannlab.bsky.social 🎉 🦃🎉 @jitchatterjee1.bsky.social @rashab.bsky.social @lsw18.bsky.social

Excited to share a new paper from @rashab.bsky.social on exhausted CD8 T cells and low grade brain tumors in #NF1. nam10.safelinks.protection.outlook.com?url=https%3A...

Human single cell RNA-sequencing reveals a targetable CD8+ exhausted T cell population that maintains mouse low-grade glioma growth

Nature Communications - With the emergence of immune checkpoint inhibitor therapies for cancer, the authors use single-cell sequencing to assess exhausted T cell content in human glioma samples and...

nam10.safelinks.protection.outlook.com

Best research group ever! Happy Holidays to all from @gutmannlab.bsky.social

@corinaanast.bsky.social rocks the final talk at the #cancer-neuroscience last session at @neuroonc.bsky.social

Proud to work with these famous people presenting amazing work at #SNO2024 @gutmannlab.bsky.social @jitchatterjee1.bsky.social