Kelly Dawe

@corncolors.bsky.social

The UGA Plant Biology Department is hiring! Please help spread the word. We have an opening for an Assistant Professor in Plant Synthetic Biology for Strategic Resources Research. See ad for details – and join us here in Athens, GA!

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Five weeks into what has been a constant onslaught on science, working on a paper seems like such a privilege, which many of our recently fired colleagues no longer have. And a rebellious act. But mostly it's self-care. (Give yourself permission to turn off the news for the weekend.)

Yibing Zeng used synthetic centromeres to break chromosome 4 into two separate chromosomes (4a and 4b), raising the diploid chromosome number of maize from 20 to 22. The resulting plants grew and reproduced normally. We call this process engineered chromosome fission www.biorxiv.org/content/10.1...

Increased maize chromosome number by engineered chromosome fission

Activation of synthetic centromeres on chromosome 4 in maize leads to its breakage and formation of trisomic fragments called neochromosomes. A limitation of neochromosomes is their low and unpredicta...

biorxiv.org

Meghan Brady showed that one of the kinesins (Trkin) on the Ab10 meiotic drive haplotype does not serve a useful function in drive or fitness. Anjali Gupta and Rob Unckless used modeling to show that Ab10 Trkin should not persist. Something strange is going on www.biorxiv.org/content/10.1...

Antagonistic kinesin-14s within a single chromosomal drive haplotype

In maize, there are two meiotic drive systems that operate on large tandem repeat arrays called knobs that are found on chromosome arms. One meiotic drive haplotype, Abnormal chromosome 10 (Ab10), enc...

biorxiv.org

Rebecca Piri showed that the maize centromere repeat CentC likely does not have a role in centromere function, whereas knob repeat arrays (involved in meiotic drive) have conserved higher order repeats (HORs) and huge repeat units of ~1 Mb that are shared among knobs www.biorxiv.org/content/10.1...

Higher order repeat structures reflect diverging evolutionary paths in maize centromeres and knobs

Background Highly repetitive tandem repeat arrays, known as satellite DNAs, are frequently found in low recombination regions such as centromeres. Satellite arrays often contain complex internal struc...

biorxiv.org

I am pleased to introduce three papers from our lab this week, describing the structure of repeat arrays, the fitness effects of a key meiotic drive gene, and karyotype engineering.