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COVID-19 Drug Interactions

@covidinteractions.bsky.social

Updates from the COVID-19 drug interaction website from the University of Liverpool. https://www.covid19-druginteractions.org/ Please note: this account cannot give clinical advice.

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COVID-19 Drug Interactions@covidinteractions.bsky.social · 7mo ago

Still time to register for The Liverpool Course: COVID-19. We have a great programme lined up with fantastic speakers! Not to be missed! To register: www.covid19-druginteractions.org/site_news/237 #druginteractions #covid19 #DDIs #webinar

COVID-19 Drug Interactions@covidinteractions.bsky.social · 7mo ago

Join us online from 3PM GMT on Wednesday 18th February for The Liverpool Course: COVID-19! We have a great line-up of speakers and presentations focusing on the clinical management of DDIs in COVID-19. For more info and free registration 👉 www.covid19-druginteractions.org/site_news/237

COVID-19 Drug Interactions@covidinteractions.bsky.social · last yr.

🚦Updates to Paxlovid interactions: 97 yellow interactions with 5-day administration reviewed, 9 changed to 🟢GREEN, 3 changed to 🟠AMBER, and 85 kept as 🟡YELLOW with the additional comment that “coadministration has not been studied, but can be considered”.

Screenshot of yellow summary of Paxlovid (5 days) with ethinylestradiol. Summary reads: Coadministration has not been studied but can be considered. Ethinylestradiol is metabolized by hydroxylation and glucuronidation. When used in a combined pill, ethinylestradiol is expected to be reduced. This is unlikely to impair contraceptive efficacy, particularly considering the short duration of nirmatrelvir/ritonavir treatment, though it may increase the risk of irregular bleeding. However, it should be noted that the Paxlovid product labels state patients using combined hormonal contraceptives should be advised to use an effective alternative contraceptive method or an additional barrier method of contraception during treatment with nirmatrelvir/ritonavir, and until one menstrual cycle after stopping nirmatrelvir/ritonavir.