In science, successful replication is the ultimate quality check! This is a highlight for our research group—David Birnie's group (one of the biggest names in cardiac sarcoidosis) just independently replicated our CMR phenotyping work! doi.org/10.1093/ehji... #EHJIMP #CardioSky #sarcoidosis
Chetan Shenoy
@cshenoy.bsky.social
Cardiologist and researcher, in cardiovascular magnetic resonance imaging, at the University of Minnesota
Related: you’ve definitely made me more conscious about not calling something «ischemic cardiomyopathy» just because there is coronary disease as it might just be a bistander.
🧵 Are OCT and CMR really "complementary" in MINOCA? Or are they telling us conflicting stories? Reynolds et al (Circulation 2026) combined both modalities in 284 MINOCA patients. The results raise more questions than answers. 📄 www.ahajournals.org/doi/abs/10.1... 1/7
American Heart Association Journals
ahajournals.org
Have you ever wondered whether your patient with CAD and cardiomyopathy truly has ischemic cardiomyopathy, or whether the CAD is a “bystander”? You might be interested in our paper now out in Circulation #simultaneouspublication #AHA23 #cardiosky #Medsky #WhyCMR
academic.oup.com/eurheartj/ad... #CardioSky #WhyCMR #Medsky
Prediction of ventricular arrhythmic outcomes in suspected cardiac sarcoidosis: a comparison of cardiovascular magnetic resonance phenotyping vs. societal recommendations for implantable cardioverter-defibrillator placement academic.oup.com/eurheartj/ad... #Cardiosky #WhyCMR #Epeeps #Medsky
Important multicenter study in #EHJ #CMR outperforms societal recs for ICD placement in cardiac sarcoidosis 📈AUC=0.86 for 5-yr risk of fatal/life-threatening arrhythmias ⚡Highest risk = abnl LVEF + LGE that is multifocal, septal, subepicardial, or involves RV freewall buff.ly/Nc2upbU #cardiotwitter
Must-watch lecture on cardiomyopathy and CMR by @cshenoy.bsky.social „more often than what is the EF we should ask the why?“ youtube.com/live/9or85hk...
Identifying the Cause of Cardiomyopathy Using CMR (Chetan Shenoy, MBBS, MS)
YouTube video by Houston Methodist DeBakey CV Education
youtube.com
“CMR phenotyping can be used immediately in clinical practice to identify patients with suspected cardiac sarcoidosis who would benefit from a primary prevention ICD," said Chetan Shenoy, MD. Read more about how this can prevent life-threatening ventricular arrhythmias: www.tctmd.com/news/cmr-may...
CMR May Improve Assessment of ICD Need in Cardiac Sarcoidosis
The imaging was better than societal recommendations at discriminating long-term risk of ventricular arrhythmias.
tctmd.com
Thank you, @toddneale.bsky.social, for your excellent reporting on our EHJ paper! @tctmd.bsky.social @escardio.bsky.social @paragbawaskar.bsky.social
CMR May Improve Assessment of ICD Need in Cardiac Sarcoidosis
#EHJCVI 🫀 What's the value of ventricular strain in systemic sclerosis? 📉 Both LVGLS and RVGLS are linked to death or MACE, unlike LVEF and RVEF 🧠 How does strain compare to traditional prognostic markers? 🔍 Read more 👉 doi.org/10.1093/ehjc... #CardioSky @jgrapsa.bsky.social @escardio.bsky.social
Prediction of ventricular arrhythmic outcomes in suspected cardiac sarcoidosis: a comparison of cardiovascular magnetic resonance phenotyping vs. societal recommendations for implantable cardioverter-defibrillator placement academic.oup.com/eurheartj/ad... #Cardiosky #WhyCMR #Epeeps #Medsky
academic.oup.com/eurheartj/ad... @escardio.bsky.social #Cardiosky #WhyCMR #Epeeps #Medsky Please DM me if you would like a full-text PDF of the paper!
Cardiac sarcoidosis is a undervalued disease and difficult to diagnose and treat, considering potential life-threatening arrhythmias. Nice to have some more guidance. #cardiosky.
academic.oup.com/eurheartj/ad... @escardio.bsky.social #Cardiosky #WhyCMR #Epeeps #Medsky Please DM me if you would like a full-text PDF of the paper!
academic.oup.com/eurheartj/ad... @escardio.bsky.social #Cardiosky #WhyCMR #Epeeps #Medsky Please DM me if you would like a full-text PDF of the paper!
pmc.ncbi.nlm.nih.gov/articles/PMC... #HCM #CardioSky #Cardiomyopathy
Comparisons against baseline within randomised groups are often used and can be highly misleading
In randomised trials, rather than comparing randomised groups directly some researchers carry out a significance test comparing a baseline with a final measurement separately in each group. We give se...
pmc.ncbi.nlm.nih.gov
In patients with non-obstructive HCM, there was a reduction in myocardial T1 time with Eplerenone, consistent with a reduction in diffuse myocardial fibrosis. #HCM #CardioSky #Cardiomyopathy
In patients with suspected cardiac sarcoidosis, cardiac FDG-PET is recommended after a normal CMR if there is a high clinical suspicion. What are the data supporting this recommendation? #CardioSky #MedSky #Sarcoidosis
Query sarcoid, normal #WhyCMR, so then should we do FDG-PET? Not much benefit.
In patients with suspected cardiac sarcoidosis, cardiac FDG-PET is recommended after a normal CMR if there is a high clinical suspicion. What are the data supporting this recommendation? #CardioSky #MedSky #Sarcoidosis
In patients with suspected cardiac sarcoidosis, cardiac FDG-PET is recommended after a normal CMR if there is a high clinical suspicion. What are the data supporting this recommendation? #CardioSky #MedSky #Sarcoidosis
This paper reports the coexistence of cardiac sarcoidosis and arrhythmogenic cardiomyopathy in 5 patients. heart.bmj.com/content/earl... #CardioSky #MedSky
Coexistence of cardiac sarcoidosis and arrhythmogenic cardiomyopathy-associated genetic variants: a multicentre case-control study
Background Cardiac sarcoidosis (CS) is a chronic inflammatory disease characterised by non-caseating granulomas, while arrhythmogenic cardiomyopathy (ACM) is a genetic condition mainly affecting desmo...
heart.bmj.com
Great thread on LV thrombus and embolism risk - especially if RWMA I discuss lifelong anti coagulation with my pts even if it looks resolved on echo, good to have some data to help back this up 👇
In 2019, we wrote a paper showing that patients with left ventricular thrombus have a long-term risk of embolism, extending to at least 8 years. We were puzzled by the finding… #CardioSky www.ahajournals.org/doi/10.1161/...
Amazing achievement by rising star and post-doc in my lab @paragbawaskar.bsky.social, winner of the prestigious 2024 Melvin Judkins Early Career Investigator Award at #AHA24!! Congratulations!!! @ahascience.bsky.social
It’s great that journals are coming over here, but what I have really missed after my departure from Twitter 2 years ago is this, the authors themselves presenting their works and discussing it with peers. #cardiosky #medsky #emimcc
In 2019, we wrote a paper showing that patients with left ventricular thrombus have a long-term risk of embolism, extending to at least 8 years. We were puzzled by the finding… #CardioSky www.ahajournals.org/doi/10.1161/...
With the big caveat that obvious alternative causes are not present such as AF.
All patients with stroke is unrealistic in terms of cost, access and resourcing. However in patients with ischaemic stroke, LV dysfunction and/or recent MI I agree (if #echofirst + contrast is negative for thrombus).
Thanks. So for example - post anterior infarct, persisting WMA on CMR at 6 months despite OMT (but improvement in overall LVEF). Lifelong anticoagulation or would you reimage at a further interval (I.e. 12 months) to look for improvement in wall motion abnormality?
Great work Chetan. An important area where as a community we need to get better at managing - particularly in the post (anterior) STEMI space. What are your thoughts on stopping anticoagulation at 3 or 6 months post MI with persisting wall motion defects but resolved thrombus?
Congratulations for this work! Do you have data for patients with CMR and echo to evaluate the discrepancy? We need a well designed RCT to answer this important although infrequent question. And to assess the effectiveness of DOAC in these cases
In 2019, we wrote a paper showing that patients with left ventricular thrombus have a long-term risk of embolism, extending to at least 8 years. We were puzzled by the finding… #CardioSky www.ahajournals.org/doi/10.1161/...