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Cláudia Vilhena

@cvilhena.bsky.social

Junior Group Leader @fau.de 🦠 EVs 🧬 pneumococcus 🧫🔬 Associate Editor @isev.org @asm.org Former @lmu.de, @leibniz-hki.de& @natbiotech.nature.com 🇵🇹📚🦁(she/her) https://singlecell-vilhena.website2.me/

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Cláudia Vilhena@cvilhena.bsky.social · 5mo ago

#VAAM2026 is kicking off today in Berlin!🦠 The #BIDlab will be represented by the fantastic Miriana Battista who will be presenting our latest work on Poster IB-024 on Tuesday 🙌🏻🙏🏻👌🏻😍 stop by! #microbiology #streptococcuspneumoniae #extracellularvesicles

VAAM e.V.@vaam-microbes.bsky.social · 5mo ago

✨ On Sunday, the VAAM Annual Conference finally kicks off 🚀 We can't wait to welcome the VAAM family and are looking forward to great days of microbiology, exchange, and networking. Wishing everyone safe travels and see you in Berlin🧸 🦠🧬🔬 #VAAM2026 #Microbiology #Berlin

Nature Portfolio@natureportfolio.nature.com · 6mo ago

Extracellular vesicles (EVs) are emerging as biocompatible carriers for targeted drug delivery. A Review in Nature Reviews Bioengineering compares EVs with lipid-based systems and outlining strategies for improving therapeutic translation and reporting standards. 🔒

The status of extracellular vesicles as drug carriers and therapeutics - Nature Reviews Bioengineering

Extracellular vesicles (EVs) are emerging as biocompatible carriers for targeted drug delivery, yet challenges in yield, cargo loading and biodistribution persist. In this Review, key trends from over a decade of research are analysed, comparing EVs with lipid-based systems and outlining strategies for improving therapeutic translation and reporting standards.

go.nature.com

Cláudia Vilhena@cvilhena.bsky.social · 9mo ago

🧵1/2- So so happy to share our very first publication from the #BIDlab! 🥳 🎉 🙏 A huge thanks to our super talented PhD student Miriana Battista and our amazing collaborators @appsysbio.bsky.social and Christoph Saffer for the work and support 👌 🙏 ⏩ pubs.acs.org/doi/full/10....

Mechanistic Insights into the Role of Extracellular Vesicles at the Bacterial–Host Interface

Bacterial and human cells produce extracellular vesicles (EVs) in response to diverse stimuli, e.g., toxins, oxidative stress, nutrient depletion, or high cell density. Here, we describe a cocultivation platform that allows recovery of mixed extracellular vesicles (mix-EVs) produced simultaneously by both cell types. We investigated interactions between Gram-positive and Gram-negative bacteria (Streptococcus pyogenes, Staphylococcus aureus, Escherichia coli, and Neisseria meningitidis) and human peripheral blood mononuclear cells (PBMCs). The production of the mix-EVs population decreased with higher bacterial concentrations. Exposing PBMCs to mix-EVs repressed the general transcriptomic signature, in contrast with a significant upregulation generated by single bacterial-EVs. However, mix-EVs-derived IL-1β upregulation was confirmed at the protein level. Inhibition experiments showed that IL-1β production involved TLR2 and TLR4 signaling, acting through IRAK-1 and TRAF6 related pathways. This approach provides a new platform for the study of EVs at the pathogen–host interface and presents mechanistic insights into the effect of EVs on an infected host.

pubs.acs.org

Cláudia Vilhena@cvilhena.bsky.social · 9mo ago

Today is #WorldPneumoniaDay 🫁🦠😷 Even though steps have been taken to tackle this deadly infectious disease, a long road still lies ahead. To mark this day, I wrote a short article for @infect-net.bsky.social 📖 English version will come soon!

Infect-Net@infect-net.bsky.social · 9mo ago

🫁 Heute ist Welt-Pneumonia-Tag! Noch immer sterben weltweit zu viele Kinder an #Lungenentzündung. Dr. Cláudia Vilhena von der FAU Erlangen hat die wichtigsten Fakten zur #Pneumonie für uns zusammengestellt: 👉 www.infectnet.org/web/blog-pos... @fau.de @cvilhena.bsky.social #wpd2025 #pneumoniaday

Cláudia Vilhena@cvilhena.bsky.social · 10mo ago

The #BIDlab is 1 year old! 🎂🙏🏻👩🏻‍🔬🎉🥳👯 🧵#1 On Oct 1st 2024 we started this crazy journey: 1 junior group leader, 1 PhD student, a small office and a tiny budget. Ups&downs and a lot of hard work later, we have enlarged the group, got funding in, have 1 accepted paper and

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Cláudia Vilhena@cvilhena.bsky.social · last yr.

Bacterial EVs & vaccine design 👌🤩 read the full article in JEV @isev.org #proudEditor #newPI #extracellularvesicles #bacterialEVs #OMVs isevjournals.onlinelibrary.wiley.com/doi/10.1002/...

Development of a Recombinant Outer Membrane Vesicles (OMVs)‐Based Vaccine Against Helicobacter pylori Infection in Mice

This study innovatively modified the structure of LPS for the recombinant H. pylori OMV vaccine, and utilised the vector advantage of OMVs to deliver the H. pylori main antigen proteins UreB, VacA an...

isevjournals.onlinelibrary.wiley.com