🚀 CCP is growing! Join our team and become part of a leading European research infrastructure in phenogenomics. Several positions are open now. 👉check the Latest News on our website: www.phenogenomics.cz #CCP #Phenogenomics #ResearchJobs
Czech Centre for Phenogenomics (CCP)
@czphenogenomics.bsky.social
We are a large research infrastructure providing a comprehensive "one-stop shop" for the genetic engineering, advanced phenotyping, and preclinical testing of rodent and cell-based models to decipher gene function and model human diseases.
Thanks to @Scintila, we welcomed Maria Rosaria Imperato from @STEMCELL Technologies, who presented their human iPSC research platform and its potential for advanced human models. A valuable insight into innovative tools for human-relevant research. #HumaniPSC #NewAdvancedModels #StemCellResearch
Nice piece of work. We are proud to have contributed our expertise to this publication: JCI Insight - IFN-γ–producing self-reactive CD4+ T cells induce autoimmune adrenalitis in a mouse model of Addison’s disease insight.jci.org/articles/vie...
JCI Insight - IFN-γ–producing self-reactive CD4+ T cells induce autoimmune adrenalitis in a mouse model of Addison’s disease
1Laboratory of Adaptive Immunity, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czechia.
insight.jci.org
🧬 New study in Nature Communications: Czech scientists uncovered a mechanism behind a rare neurodevelopmental disorder linked to EHMT2 variants. CCP created and characterised a mouse model carrying the patient-specific variant, supporting future research into disease mechanisms and therapies.
A huge thank you to all speakers, and especially to the patient organisations who made Session 8 on rare diseases & (gene) therapies so powerful. Your voices matter and the lively discussion showed why patients must be at the heart of research. 💙 #RareDiseases
🎉 Thank you to all 321 participants, 39 speakers and our amazing organisers for a fantastic 8th CCP Phenogenomics Conference! 🧬🔬 See you at the 9th CCP Phenogenomics Conference in Prague, 16–17 September 2027, on site & online! 🇨🇿
💙 #CCPConference2026 closed with a powerful patient-research session: SPATA5, Angelman syndrome & ADSL deficiency, bringing families, foundations & scientists together. The conference concluded with Kiran Musunuru on therapeutic gene editing. 🧬
🧬 Session 7 at the #CCPConference: from gene discovery to targeted therapy. Carlo Rivolta explored the genetics of inherited retinal diseases, while David Staněk showed how patient-derived models enabled targeted ASO correction of a pathogenic PRPF31 splicing mutation. 👁️
🔬 Technology Talks at the #CCPConference showcased tools enabling advanced preclinical research: multimodal PET/SPECT/CT & optical imaging, next-generation MRI, and digital PCR for rare disease research from disease modelling to therapy monitoring.
🚀 Young scientists took the stage at the #CCPConference Flash Oral Presentations, sharing work on CRISPR founder mice, AI-driven immunophenotyping and a humanized mouse model of ultra-rare MFM13.
🧬 This morning at the #CCPConference: from gene function to therapy development. Talks covered cognitive phenotyping & GABAA modulation in Huntington’s disease, allele-selective cityRNAs for SNVs, and an innovative AAV strategy for LAMA2 muscular dystrophy. 🔬🧪
From genotype to phenotype 🧬 Thursday’s final session connected variant biology, precision medicine and therapy. Stanley T. Crooke presented n-Lorem’s approach to developing personalized ASOs for patients with pathogenic mutations—free for life. #CCPConference2026 #RareDiseases
From disease mechanisms to therapies 🧬 Session 3 at #CCPConference2026 explored genome editing, liver disease, epigenetic disorders and renal cyst formation. Understanding when, where and how gene function goes wrong is key to effective intervention.
From models to therapies 🔬 Yesterday’s Session 2 at #CCPConference2026 showcased how advanced preclinical models can bridge disease mechanisms and treatment: The key message: the right model can turn genetic insight into therapeutic opportunity. #RareDiseases #Phenogenomics
We were delighted to open Thursday’s #CCPConference programme with a video greeting from Adam Vojtěch, Minister of Health of the Czech Republic, followed by opening remarks from Radomír Pánek, President of the Czech Academy of Sciences. A great start to a day of inspiring science! 🧬🔬
🏆 Celebrating 10 years of CCP by recognising the people behind its success. At #CCPConference, CCP Director Radislav Sedláček presented Recognition Awards to three colleagues: Jan Procházka, Lenka Červená and Vendula Novosadová for their extraordinary contribution to building CCP. Thank you! 💙
👏 Thank you, Tim Bertram, for joining #CCPConference and for an inspiring talk on translating cell & gene therapy discoveries into clinical and commercial outcomes. His presentation sparked a lively discussion and many questions from our audience!
🧬 What can gene discovery reveal about retinal disease? At #CCPConference, 👉https://www.ccp-conference.cz Carlo Rivolta, PhD, will explore how molecular genetics of inherited retinal diseases provides new insights into retinal biology, disease mechanisms and therapeutic opportunities.
🧬 When can treatment still change the course of neurodevelopment? At #CCPConference, 👉https://www.ccp-conference.cz/ Hans Tómas Björnsson, MD, PhD, will explore therapeutic windows in histone methyltransferase disorders and evidence that epigenetic disease may remain reversible.
🧠 Meet Dr Mariah Lelos, Cardiff University, at #CCPConference 2026! She will present how longitudinal cognitive phenotyping in a mouse model of Huntington’s disease reveals deficits before motor symptoms, and how GABAₐ modulators may improve cognitive function. 🔗 www.ccp-conference.cz/programme/
CCP joins the @INFRAFRONTIER webinar on Complex In Vitro Modelling, 19 Oct. Dr. Lenka Hromádková will present “iPSC Generation and Quality Control” and their applications in disease modelling. 👉 www.infrafrontier.eu/date/webinar...
Meet our speaker: Kiran Musunuru! 🧬 At #CCPConference2026, he will explore therapeutic gene editing for cardiovascular & metabolic diseases, including emerging platforms for personalized gene-editing therapies. From human genetics to transformative treatments. 👉https://www.ccp-conference.cz/
Meet our speaker: Stanley T. Crooke! 🧬 Founder of n-Lorem, he pioneered antisense therapeutics. At #CCPConference2026 👉https://www.ccp-conference.cz/, he will present the n-Lorem approach to developing personalized ASOs for patients with nano-rare diseases—and providing them free for life.
Meet our speaker: Tim Bertram! 🔬 At #CCPConference2026 👉https://www.ccp-conference.cz/, he will explore how scientific discoveries become technologies—and ultimately medicines, highlighting our collaboration on UMOD & MUC1 rat models for rare kidney disease. 📍Prague & Online
📢 We're hiring! The CCP is looking for two scientific leaders: 🧬 Head of the Transgenic & Archiving Module (TAM) 🧫 Head of the New Approach Methodologies (NAM) Module More & apply: 🔗 TAM: www.phenogenomics.cz/2026/07/head... 🔗 NAM: www.phenogenomics.cz/2026/07/head... #Hiring #BiomedicalResearch
📢The 8th CCP Phenogenomics Conference 2026, 9–11 Sept, Prague & Online Rare and genetic diseases, experimental models, gene and cell therapies, and personalised gene editing. 👉Programme & registration: www.ccp-conference.cz #RareDiseases #GeneTherapy #Phenogenomics
On June 4, 2026, we welcomed U.S. Ambassador to the Czech Republic Nicholas Merrick and Tuba Fehr (Program Director at NIBIB) to our center. We were pleased to showcase our unique research infrastructure, incl. a rare behind-the-scenes look beyond the phenobarrier. #Science #ResearchInfrastructure
Thank you to everyone who visited the Czech Centre for Phenogenomics at Veletrh vědy 2026! 🧬🔬 Special thanks to our CCP volunteers for creating such fun, interactive experiences for visitors of all ages. Your enthusiasm made science engaging, inspiring, and memorable! #ScienceForAll
🔬🧬 Meet science up close at the Science Fair 2026 in Prague! Visit the CCP booth (no.5, hall 2) and discover the world of genetics through hands-on activities for all ages: Create and explore cells; Try a BSL3 lab photo corner; Test your senses and learn about phenotyping; Explore genes.
