My colleague @socialinfluenza.bsky.social has written an absolutely excellent explainer for @theconversation.com about our recent paper with @dalan-bailey.bsky.social identifying a new human surface receptor for alphacoronaviruses: theconversation.com/scientists-h...
Scientists have found a safer way to hunt for the next pandemic virus
Scientists are learning to spot pandemic threats without touching dangerous pathogens.
theconversation.com
Really important discussions yesterday between our lab and @davidlvbauer.bsky.social . Thanks for hosting us at the Crick for a triple lab meeting with the Malquer lab!
A study in Nature finds that a subset of bat alphacoronaviruses (a major group of coronaviruses) has the potential to enter human cells by exploiting a previously unknown cellular gateway. 🧪
Heart-nosed bat alphacoronaviruses use human CEACAM6 to enter cells - Nature
Human CEACAM6, which is widely expressed in the lung, is identified as a receptor used by the spike proteins of Cardioderma cor (heart-nosed bat) alphacoronaviruses to enter cells.
go.nature.com
Took a long time to get this done, 2-3 years on Figure 1 alone but glad it's finally out!! www.nature.com/articles/s41...
Heart-nosed bat alphacoronaviruses use human CEACAM6 to enter cells - Nature
Human CEACAM6, which is widely expressed in the lung, is identified as a receptor used by the spike proteins of Cardioderma cor (heart-nosed bat) alphacoronaviruses to enter cells.
nature.com
And the sister paper from collaborator and good friend Katie Doores ... A deeper dive into how some of these broadly neutralising #sarbecovirus #coronavirus #sars2 #covid antibodies actually work www.biorxiv.org/content/10.1...
Mechanisms for cross–neutralisation of diverse bat sarbecoviruses
The continuing evolution of SARS–CoV–2 variants of concern, and the increasing spillover potential of sarbecoviruses into the human population presents an important and urgent need to discover cross-r...
biorxiv.org
Our first post on here and it's a doozy 😍🤩. Our epic piece on #sarbecovirus host range. #virology #sars2 #covid #vaccines. Enjoy and please repost. www.biorxiv.org/content/10.1...
Understanding the future risk of bat coronavirus spillover into humans: correlating sarbecovirus receptor usage, host range, and antigenicity.
Sarbecoviruses interact with their receptor, angiotensin converting enzyme 2 (ACE2), via the receptor binding domain (RBD) of Spike, the immunodominant target for neutralising antibodies. Understandin...
biorxiv.org