Our lab's paper on the de novo design of small-molecule binding proteins is out! In it, we show how neural nets can be trained and used to design binders to drugs with very high success rates. www.nature.com/articles/s41...

Zero-shot design of drug-binding proteins via neural iterative selection−expansion - Nature

 By pairing two neural networks in an iterative optimization algorithm, small-molecule binding proteins can be designed from scratch with high accuracy, affinity and success rates, showing p...

nature.com

Out now as a preprint, “Molecular basis of mitochondrial leucine transport by human Sideroflexin 1”. #CryoEM #Mitochondria #StructuralBiology www.biorxiv.org/content/10.6...

Published today in Cell Chemical Biology, our Cryo-EM structure of PP2A/B55α with IER5 and identification of IER5 structural homologues SERTADs using structural bioinformatics. Congratulations to Aster and @blacklowlab.bsky.social authors! www.sciencedirect.com/science/arti...

Molecular mechanism of PP2A/B55α phosphatase inhibition by IER5

PP2A serine/threonine phosphatases are heterotrimeric complexes that execute many essential physiologic functions. These activities are modulated by a…

sciencedirect.com

Great to see our work on protein phosphatase 2A (PP2A) and IER5 featured in a recent review by Peti and Page labs. Particular focus on our work identifying structural homology between IER and SRTD proteins using a conserved alpha helical hairpin motif. www.sciencedirect.com/science/arti...

Combining cryo-electron microscopy (cryo-EM) with orthogonal solution state methods to define the molecular basis of the phosphoprotein phosphatase family regulation and substrate specificity

Protein phosphatases are dynamic enzymes that exhibit complex regulatory mechanisms, with disruptions in these regulatory processes associated with di…

sciencedirect.com

Cuts in NIH research grants will have a lasting negative impact on science and medicine in the U.S. Grants will continue to fund specific research costs, but essential infrastructure like labs, advanced equipment and support staff are crucial for groundbreaking work.

Online @cellpress.bsky.social, we reveal a protein shell that helps diatoms fix 20% of global #CO2 🧪🌊🌾🧶🧬🌍 Shimakawa et al: www.cell.com/cell/fulltex... Nam et al: www.cell.com/cell/fulltex... @biozentrum.bsky.social press release: www.biozentrum.unibas.ch/news/detail/... Read on for more... 1/🧵

Diving into Rosetta this Sunday morning with a mutation scan and a coffee.

It’s nice to have a feed filled with science rather than all that other stuff. Hope it stays that way.

Earlier this year we published functional profiles of all 33 adhesion GPCRs in signalling/biosensor assays. Led by recently graduated Drew Dates, we found a dichotomy of tethered agonist dependent and independent receptors. www.sciencedirect.com/science/arti...

Our recent story on the mechanism of PP2A/B55 inhibition by IER5 - a notch target gene essential for keratinocyte differentiation in squamous cell carcinoma cells. We use functional assays, biochemistry and Cryo-EM to determine the molecular mechanism www.biorxiv.org/content/10.1...