Challenged by the complexity of explaining GLP-1 medicines to friends and family? Gustav Hållén the talented producer of Zero Order has figured it out. Have a listen www.youtube.com/watch?v=VCIW...
Daniel Drucker
@danieljdrucker.bsky.social
A clinician scientist at LTRI @sinaihealth studying Glucagon, GIP, GLP-1, GLP-2, diabetes, obesity, metabolism and the gut endocrine system
The evolving resolution of islet ultra structure @diabetologiajnl.bsky.social link.springer.com/article/10.1...
Islet ultrastructure: past achievements and future directions - Diabetologia
Islets of Langerhans constitute the endocrine component of the pancreas and comprise the main cell types responsible for the regulation of glucose homeostasis. Beta cells produce and secrete insulin, ...
link.springer.com
P3 data assessing the efficacy and safety of setmelanotide once daily in acquired hypothalamic obesity over 52 weeks www.nejm.org/doi/full/10....
Setmelanotide for the Treatment of Acquired Hypothalamic Obesity | NEJM
A phase 2 trial of setmelanotide, a melanocortin-4 receptor agonist, showed substantial weight loss in patients with acquired hypothalamic obesity, but additional data are needed. We conducted a ph...
nejm.org
More evidence from studies of mice deficient in α cells that α cells are required for nutrient homeostasis by regulating the dynamics of β cell networks, notably under conditions of amino acid exposure www.science.org/doi/10.1126/...
Pancreatic α cells are required for nutrient homeostasis by regulating dynamic β cell networks in islets
Islet α cells are required for meal tolerance by tuning synchrony, cluster size, and signal propagation of β cell networks.
science.org
A metabolic update and perspective on #MASLD #MASH @diabetologiajnl.bsky.social link.springer.com/article/10.1...
Metabolic drivers of MASLD and MASH: from hormonal imbalance to fibrosis - Diabetologia
Metabolic dysfunction-associated steatotic liver disease (MASLD) and its more severe and aggressive form, metabolic dysfunction-associated steatohepatitis (MASH), represent liver-specific consequences...
link.springer.com
Irisin induction in response to exercise confers direct neuroprotective effects in an inflammation-driven neurodegenerative condition in mice, making it an attractive therapeutic candidate for multiple sclerosis @natmetabolism.nature.com www.nature.com/articles/s42...
The exercise hormone irisin has neuroprotective effects in a mouse model of multiple sclerosis - Nature Metabolism
Exercise-mediated neuroprotection in a mouse model of multiple sclerosis is reduced in mice lacking the irisin-encoding gene, Fndc5, and can be recapitulated by peripheral administration of irisin.
nature.com
Amyloid-dependent StAR upregulation in beta cells under conditions of islet amyloid deposition could contribute to mitochondrial dysfunction @diabetologiajnl.bsky.social link.springer.com/article/10.1...
Human islet amyloid polypeptide aggregation upregulates the mitochondrial cholesterol transport protein StAR and induces mitochondrial dysfunction in beta cells - Diabetologia
Aims/hypothesis Loss of islet beta cell function and mass are critical in the pathogenesis of type 2 diabetes, a disease in which ~90% of individuals exhibit islet amyloid deposition. Amyloid deposits...
link.springer.com
New experimental insights into vagal mechanisms triggered by allulose to improve insulin sensitivity diabetesjournals.org/diabetes/art...
Honored to share that Dr. Gökhan Hotamışlıgil has been elected to the National Academy of Sciences, one of the highest distinctions in science recognizing outstanding, sustained contributions to research. Huge congratulations to Dr. Hotamışlıgil on this remarkable and well-deserved honor!
National Academy of Sciences Elects Members and International Members - NAS
WASHINGTON — The National Academy of Sciences announced today the election of 120 members and 25 international members in recognition of their distinguished and continuing achievements in original res...
nasonline.org
Supporting the concept that GLP1 agonist drugs lower blood pressure independent of weight loss: doi.org/10.1172/jci.... @danieljdrucker.bsky.social & team @sinaihealth.bsky.social identify the vascular smooth muscle GLP-1 receptor as a key cellular target for GLP-1s to lower BP
Could Ozempic be the solution to inflammatory diseases? Perhaps not for all of them, but compelling research from @danieljdrucker.bsky.social's lab and others is exploring where GLP-1s' anti-inflammatory properties could have meaningful clinical benefits. My latest @sciam.bsky.social
Ozempic’s greatest benefit may be their anti-inflammatory power
A growing body of research suggests that GLP-1 drugs do more than control appetite and blood sugar. They could also fight inflammation
scientificamerican.com
🏆We're proud to announce Prof. Anette Ziegler as the recipient of the 58th EASD Claude Bernard Prize: the highest honour our association bestows.Her career has been driven by 1 vision: a world w/out #T1D. Join us in celebrating her at #EASD2026. 🔗👉 www.easd.org/prizes/claud... Supported by Sanofi
A potentially targetable pathogenic signature of EV-associated miRNAs capable of stratifying type 1 diabetes risk #islets @diabetologiajnl.bsky.social link.springer.com/article/10.1...
Here the authors highlight potential therapeutic benefits of 4 weeks of β2-AR stimulation for improving muscle-specific glucose uptake in individuals with or at risk for developing diabetes #T2D www.nature.com/articles/s41...
Prolonged β2-agonist treatment enhances muscle-specific glucose uptake in individuals with overweight and obesity: a randomized placebo-controlled trial - Nature Communications
The study showed in a placebo-controlled crossover design that 4-week treatment with β2-adrenergic agonist clenbuterol enhances insulin-stimulated glucose uptake in skeletal muscle but not brown adipo...
nature.com
Revisiting changes in cognitive function and biomarkers of Alzheimer’s disease in REWIND alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Dulaglutide and neurodegeneration biomarkers: REWIND post hoc analysis
INTRODUCTION This post hoc analysis of the Researching Cardiovascular Events with a Weekly Incretin in Diabetes (REWIND) trial examined associations between dulaglutide, Alzheimer's disease and rela...
alz-journals.onlinelibrary.wiley.com
The role of fructose not only as a caloric source, but also as a regulator of metabolic health and disease www.nature.com/articles/s42... @natmetabolism.nature.com
Fructose: metabolic signal and modern hazard - Nature Metabolism
Johnson et al. discuss the role of dietary and endogenous fructose as a calorie source and modulator of metabolic health and disease.
nature.com
Although #weightloss is highly beneficial to reduce fat and inflammation in the liver, posthoc analysis of the ESSENCE trial reveals substantial weight loss-independent benefits of semaglutide #MASH How does this happen?
Pediatric #MASLD @diabetologiajnl.bsky.social link.springer.com/article/10.1...
Updates on paediatric MASLD: insights from an endocrine lens - Diabetologia
Paediatric metabolic dysfunction-associated steatotic liver disease (MASLD) is the leading cause of chronic liver disease in children and adolescents worldwide and is increasing alongside rising rates...
link.springer.com
Neuronal lipid droplet-derived lipids support neuron function by providing fatty acids and phospholipids to sustain mitochondrial and endoplasmic reticulum function and homeostasis. www.nature.com/articles/s42...
Neuronal lipid droplets play a conserved and sex-biased role in maintaining whole-body energy homeostasis - Nature Metabolism
In vivo regulation of neuronal lipid droplet formation mediates whole-body energy homeostasis in a sex-specific manner in Drosophila and mice.
nature.com
Genetic screens provide mechanistic insights into the regulation of proinsulin/insulin homeostasis www.nature.com/articles/s41...
Proinsulin regulators identified with CRISPR screen and in vivo mouse QTL mapping - Nature Communications
This study uses genome-wide screening and mouse genetics to uncover how cells control proinsulin, identifying the Golgi as a central hub and revealing PDIA6 as a key regulator of proinsulin production...
nature.com
Expanding the #genetics of #pregnancy associated nausea and vomiting www.nature.com/articles/s41...
Multi-ancestry genome-wide association study of severe pregnancy nausea and vomiting - Nature Genetics
Multi-ancestry GWAS meta-analysis identifies risk loci for severe nausea and vomiting of pregnancy. Downstream analyses explore maternal and fetal contributions of these loci and their temporal effect...
nature.com
A new review on GIP from the experts. While the narrative clearly highlights GIPR agonism suppresses food intake, the Figure implies GIP increases food intake diabetesjournals.org/care/article...
Towards actionable ascertainment of #diabetes risk in cluster subtypes with #weightloss diabetesjournals.org/diabetes/art...
Here the authors propose that TOX3 in POMC-lineage cells are essential for maintaining energy homeostasis in mice, driving thermogenesis, thereby revealing therapeutic opportunities for metabolic disorders #obesity www.nature.com/articles/s41...
TOX3 in hypothalamic POMC-lineage cells regulates energy balance via the PTEN-AKT signaling axis - Nature Communications
Hypothalamic POMC neurons are critical for energy balance. Here, authors show that TOX3 in these neurons regulates metabolism by promoting PTEN degradation and AKT activation, enhancing thermogenesis ...
nature.com
New from Professor Belsham @denisebelsham.bsky.social The naturally ocurring phytohormone BAP causes #weightloss in obese mice via sex-specific mechanisms www.sciencedirect.com/science/arti...
The plant hormone, 6-benzylaminopurine, ameliorates obesity in male and female mice while on a high-fat diet
Obesity is a global health crisis. Currently available treatments, while effective, show several undesirable side effects that hinder their long-term …
sciencedirect.com
Happy birthday to Professor Emeritus Bernie Zinman, newly elected member of the @CdnMedHallFame @uoftmedicine @SinaiHealth www.cdnmedhall.ca/bernard-zinm... #diabetes @DiabetesCanada
As the therapeutic benefits of GLP-1 medicines expand, the interest in the weight loss independent contributions continues to unfold linkinghub.elsevier.com/retrieve/pii...
Potential cerebrovascular benefits of GLP-1 medicines in real world data for patients with moyamoya disease thejns.org/view/journal...
thejns.org
In rats, amylin modulates emotional and social behaviors in a divergent sex-dependent manner www.nature.com/articles/s41...
Not only gut feelings: pancreatic hormone, amylin, controls emotionality and sociability, in a sex divergent manner - Translational Psychiatry
Translational Psychiatry - Not only gut feelings: pancreatic hormone, amylin, controls emotionality and sociability, in a sex divergent manner
nature.com
A new chapter from the Scherer lab on adipose tissue communication via extracellular vesicles www.nature.com/articles/s41...
Adipocytes signal to recruit specific mRNAs from surrounding cells to restore expression deficits - Nature Communications
Extracellular vesicles (EVs) mediate intercellular communication by transferring signaling macromolecules. Unexpectedly, the author here identifies that adipocyte-specific loss of SMPD3 triggers neighboring preadipocytes to release EVs containing SMPD3 mRNA, restoring SMPD3 expression in genetically null adipocytes.
nature.com