#2025ISMPMI 📣 In silico screening of PRR-epitope interactions is now possible! Here, we developed mamp-ml to predict their immunogenic outcomes without structural context. Let's accelerate engineering plant receptors for robust resistance! 🚀🌱 Small 🧵 www.biorxiv.org/content/10.1...

mamp-ml: A deep learning approach to epitope immunogenicity in plants

Eukaryotes detect biomolecules through surface-localized receptors, key signaling components. A subset of receptors survey for pathogens, induce immunity, and restrict pathogen growth. Comparative gen...

biorxiv.org

Great presentation from @gittacoaker.bsky.social on kinase mediated defense responses and harnessing the power of language models for receptor/ ligand prediction. These LMs will help us in engineering more resilient crops #2025ISMPMI

While I'm not going to be at #2025ISMPMI this year (🥲), @kseniakrasileva.bsky.social will be there presenting on some of our latest work that was submitted to BioRxiv today. Teaser: Plant immunity + large language models will transform receptor discovery and engineering for disease resistance. 🌱🚀

An artificial intelligence tool developed by @microsoft.com researchers can predict the multiple conformational states of proteins in minutes with a fraction of the resources required by other techniques. cen.acs.org/biological-c... #chemsky 🧪

Microsoft AI predicts protein conformations

The open-source tool goes beyond AlphaFold by finding proteins’ multiple equilibrium states and free energies

cen.acs.org

The Resistance awakens: Diversity at the DNA, RNA, and protein levels informs engineering of plant immune receptors from Arabidopsis to crops 🧬🌱 💫🚀 by Chandler Sutherland @danimstevens.bsky.social @weiweibio.bsky.social Kyungyong Seong academic.oup.com/plcell/advan...

The Resistance awakens: Diversity at the DNA, RNA, and protein levels informs engineering of plant immune receptors from Arabidopsis to crops

Plants are natural bioengineers, and we illustrate how the stunning diversity in plant immune receptors can be translated into engineering efforts from Ara

academic.oup.com

2025 has been quite a whirlwind. Learned of good funding news, had my first faculty (zoom) interview, will give my first dept. seminar on Monday at Davis all while trying to keep cool with the current news events. 😆😬🫠 To UC Davis folks, if anyone wants to meet up on Monday, feel free to reach out.

This was such a fun review to be part of and truly a group effort! 😄please feel free to check it out. 🌱

Ksenia Krasileva@kseniakrasileva.bsky.social · 2y ago

Several Jedis in our lab joined forces to review the rise of the plant immune resistance at DNA, RNA, and protein levels 💫🚀 check out the preprinted review here: zenodo.org/records/1420...

🌿 Excited to share our latest research on how host proteases regulate immune activation! Read more about how SBT5.2 releases and inactivates flg22: www.nature.com/articles/s41... rdcu.be/d1UsT Congratulations to all involved! #PlantImmunity #PlantPathology #PlantChemeticsLab

Subtilase SBT5.2 inactivates flagellin immunogenicity in the plant apoplast - Nature Communications

Plants recognize bacteria by perceiving a 22-residue epitope in flagellin. Plant-secreted SBT5.2 subtilases are found to inactivate this epitope, leading to elicitor removal and reducing costly immuni...

nature.com

One bacterial NLR recognizing three different phage proteins vis direct interaction! How cool is that? www.nature.com/articles/s41...

Diversification of molecular pattern recognition in bacterial NLR-like proteins - Nature Communications

Avs proteins are bacterial anti-phage pattern recognition receptors evolutionarily related to eukaryotic NLRs. Here, Béchon et al show that a single bacterial Avs can recognize different phage protein...

nature.com

Sometimes the smallest things warm the soul ❤️ so thankful to be part of such a great lab group!

Interested in how immune responses change over different stages of root development? 🍅🌱 Check out the preprint lead by @bleuschenkohl.bsky.social! 🥳 www.biorxiv.org/content/10.1...

Tomato roots exhibit distinct, development-specific responses to bacterial-derived peptides

### Competing Interest Statement The authors have declared no competing interest.

biorxiv.org