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Danilo Negro

@danineuro.bsky.social

Wellcome Trust PhD student in Translational Neuroscience based at UKDRI, Edinburgh University.

2 Posts124 Follower217 Folgt
The Guardian@theguardian.com · last yr.

Living human brain tissue used to mimic Alzheimer’s in breakthrough study

Living human brain tissue used to mimic Alzheimer’s in breakthrough study

Exclusive: British team exposed live cells to toxic proteins to gather rare insight into how dementia develops Scientists have used living human brain tissue to mimic the early stages of Alzheimer’s disease, the most common form of dementia, in a breakthrough that will accelerate the hunt for a cure. In a world first, a British team successfully exposed healthy brain tissue from living NHS patients to a toxic form of a protein linked to Alzheimer’s – taken from patients who died from the disease – to show how it damages connections between brain cells in real time. Continue reading...

theguardian.com

Dr Soraya M@sorayam.bsky.social · last yr.

Our paper in Nature Comms is now online! Summary below but in short we use living human brain slice cultures in a number of different ways to model dementia processes. Big team effort led by myself, @robertmcgeachan.bsky.social and @clairedurrant1.bsky.social rdcu.be/ej647

Divergent actions of physiological and pathological amyloid-β on synapses in live human brain slice cultures

Nature Communications - Understanding synapse loss in Alzheimer’s disease has been hampered by a lack of human model systems. Here, the authors show that manipulation of physiological or...

rdcu.be

Claire Durrant@clairedurrant1.bsky.social · last yr.

Amazing to welcome HRH The Duchess of Edinburgh, Patron of Race Against Dementia to our lab! An incredible opportunity to showcase our work with living human brain slice cultures and the importance of investing in dementia research. We are very lucky to have her support.

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