Dan Isom
@danisomlab.bsky.social
University of Miami, FL: molecular and cellular basis of proton sensing, synBio for health/energy and drug discovery, novel data science for protein structure-function informatics, and AI: https://www.isomlab.com
We just wrapped up the 7th Molecular & Cellular Pharmacology Retreat in the Florida Keys, and the energy was incredible. Under the theme “Colab in the Cays,” scientists from 15+ labs shared 53 talks across two days, with every single participant presenting their work.
PIONEER: A Periplasmic Display Platform for Synthetic Biology-Based Screening of Genetically Encoded Protein Regulators - Journal of Biological Chemistry www.jbc.org/article/S002...
PIONEER: A Periplasmic Display Platform for Synthetic Biology-Based Screening of Genetically Encoded Protein Regulators
Periplasmic display in yeast is a promising but underdeveloped method for screening and studying genetically encoded biomolecules. We present PIONEER, a modular platform that localizes peptides, prote...
jbc.org
Support my running of the 5K! Funds go directory to research labs @SylvesterCancer: dolphinscancerchallenge.com/participant/...
Help me Challenge Cancer!
The DCC is a year-round collective community movement to raise money in support of Sylvester Comprehensive Cancer Center at the University of Miami. With your support, we are saving more lives. #OneTe...
dolphinscancerchallenge.com
"A recent study employing parallel mutagenesis of titratable residues in GPR68 identified a conserved triad of buried acidic residues in proton sensing GPCRs. Here, too, neutral mutations to these sites shift pH50 but do not abolish proton-mediated receptor activation."
I have received many requests for this, so I am sharing it here. I hope it works (password: 7i+fFdMG) @Pap_Corps @SylvesterCancer @danIsomLab: tinyurl.com/Pap-Corps-EC...
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The combined single-day profit of the top 25 US companies would fully fund the annual $3.2B NIGMS budget.
In my excitement for his visit, I forgot to get a selfie with Henrik. This will have to do 😂
Our small review on using yeast synthetic biology to advance human GPCR biology and pharmacology. tinyurl.com/2p88y72h
Advances in yeast synthetic biology for human G protein–coupled receptor biology and pharmacology
G protein–coupled receptors (GPCRs) are the largest family of transmembrane receptors in humans. Over 800 GPCRs regulate the (patho)biology of every o…
tinyurl.com
What a wonderful scientific retreat for UM Pharmacology this week @bakerscayresort. Time is running out to join our faculty and enjoy the Keys and science for yourself! bit.ly/3GAxDD6
Looking for cool colleagues! Recruiting at assistant and associate levels. I am happy to answer any questions. www.nature.com/naturecareer...
Happy to be among this fine assembly of protonators: https://www.biophysics.org/2023tahoe-protonreaction/program/daily-schedule
Wow, SoCal feeling SoFlo.
Daniel Swain@weatherwest.bsky.social · 3y agoNew Weather West post on #HurricaneHilary and major Southern California-related impacts expected this weekend into early next week. Please also consider attending addition (time TBD) YouTube live sessions Sat-Tue as the event evolves. #CAwx #CAwater https://weatherwest.com/archives/29462
PIEZO1 action up close: https://www.nature.com/articles/s41586-023-06427-4
Cool, but SUPER TINY proteins: https://www.nature.com/articles/s41586-023-06328-6