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Dan J. Hayman

@danjhayman.bsky.social

Using Drosophila to investigate the role of RNA splicing in ageing Vivensa Foundation ECR Fellow at the Unviersity of Sheffield, hosted in the Simons Lab. PhD in ncRNAs in ageing from the Young Lab at Newcastle University with CIMA.

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Dan J. Hayman@danjhayman.bsky.social · 11mo ago

Latest exciting work from me and @mirresimons.bsky.social (and the first bit of data from my @vivensa.bsky.social ECR Fellowship) now out as a preprint, looking at effects of knocking down individual spliceosome components on lifespan in vivo: www.biorxiv.org/content/10.1...

Knockdown of the fly spliceosome component Rbp1(orthologue of SRSF1) extends lifespan

Biological regulation is a highly intricate process and involves many layers of complexity even at the RNA level. Alternative splicing is crucial in the regulation of which components of a protein-cod...

biorxiv.org

Mirre Simons@mirresimons.bsky.social · last yr.

Latest. Dan tested the importance of Drosophila immune cells by ablating or expanding them using conditional genetics. Turns out no lifespan phenotype, perhaps because there is compensation within the immune cell lineage. More exciting biology to discover. journals.biologists.com/jeb/article/...

Expansion of Drosophila haemocytes using a conditional GeneSwitch driver affects larval haemocyte function, but does not modulate adult lifespan or survival after severe infection

Macrophages are responsible for diverse and fundamental functions in vertebrates. Drosophila blood cells (haemocytes) are dominated by cells bearing a striking homology to vertebrate macrophages (plas...

journals.biologists.com

Dan J. Hayman@danjhayman.bsky.social · 2y ago

Really excited to say that from January I'll be starting as an ECR Fellow with the Dunhill Medical Trust based at the University of Sheffield, using Drosophila to look at RNA splicing in ageing! Seems as good a first post on here as I can come up with!