Protein fitness landscapes are simpler under evolutionary distributions! We show that much of the high-order epistasis observed in fitness landscapes is substantially diminished when analyzed under their natural evolutionary distributions. www.biorxiv.org/content/10.6... (1/n)

Can we learn how protein language models (pLMs) work? 👀 As a matter of fact, yes! I'm excited to shared that our paper, "Protein Circuit Tracing via Cross-layer Transcoders", has been accepted into ICML 2026! Check out our findings at protmech.github.io (1/n)

Darin Tsui@darintsui.bsky.social · 6mo ago

🚨Excited to share ProtoMech: a framework for discovering the computational circuits inside protein language models (pLMs)! pLMs like ESM2 are powerful, but the computational mechanisms, or circuits, underlying their predictions remain poorly understood. (1/n)

🚨Excited to share ProtoMech: a framework for discovering the computational circuits inside protein language models (pLMs)! pLMs like ESM2 are powerful, but the computational mechanisms, or circuits, underlying their predictions remain poorly understood. (1/n)

Excited to announce our paper, SHAP zero, has been accepted into NeurIPS 2025! SHAP zero takes the first steps toward extracting biological insights at scale from machine learning models by amortizing the cost of explanations across large-scale biological datasets.