Burge Lab
@daspliceisright.bsky.social
We study gene expression & RNA processing (RBPs, splicing, transcription) using experimental and computational methods at @MITBiology! for older posts, see our profile on X: https://x.com/daSpliceIsRight
Check out this article about the latest publication from our lab, highlighting our new method, KATMAP, for understanding and predicting gene splicing news.mit.edu/2025/katmap-...
A new way to understand and predict gene splicing
The KATMAP model, developed by researchers in the Department of Biology, can predict alternative cell splicing, which allows cells to create endless diversity from the same sets of genetic blueprints.
news.mit.edu
Chris and our lab members (pictured here), along with many other labs from MIT Biology Dept, came out to protest today during "Stand Up for Science" day!! Keep it up @standupforscience.bsky.social
Congrats to Burge lab alumna Dr. Kowal: her work on intron mediated enhancement (IME) of gene expression is officially published in Nucleic Acids Research! academic.oup.com/nar/article/...
Sequence-dependent and -independent effects of intron-mediated enhancement learned from thousands of random introns
Abstract. Spliceosomal introns are a ubiquitous feature of eukaryotic genes, whose presence often boosts the expression of their host gene, a phenomenon kn
academic.oup.com
Congrats to Burge Lab PhD Student Connor Kenny on receiving an MIT news feature, highlighting his graduate work, uncovering how the LUC7 class of proteins control subclasses of RNA splicing events: news.mit.edu/2025/mit-bio... @mitnews
MIT biologists discover a new type of control over RNA splicing
MIT biologists discovered a new type of RNA-splicing regulation that helps to determine which protein-coding exons will be included in messenger RNA transcripts.
news.mit.edu