The Open Targets Platform autumn release is out! 🍂 We have ingested the full dataset of over 13 million enhancer-gene regulatory interactions in the human genome across 1,458 DNase-seq experiments covering 369 cell types and tissues from the ENCODE-rE2G model blog.opentargets.org/open-targets...

Open Targets Platform 25.09 has been released!

The September 25 release includes enhancer-gene data predicted by ENCODE-rE2G, molQTL credible sets for targets, new options for the variant structural viewer, and a number of data updates from GWAS C...

blog.opentargets.org

🧬 New @emblebi.bsky.social service beta launched: Perturbation Catalogue 🔎 Browse genetic perturbation datasets 🧠 Train models 🧬 Interpret variant function 🧭 Explore gene dependencies Search, test APIs, suggest datasets, send feedback! 🔗 www.ebi.ac.uk/perturbation... Funded by @opentargets.org

Open Targets Platform 25.06 is out now! 🌻 It includes 36% more GWAS credible sets (including from the VA Million Veteran Program study) and a new target interactors view to help nominate potential targets blog.opentargets.org/open-targets...

Open Targets Platform 25.06 has been released!

This release brings in 36% more GWAS credible sets, association evidence for a target's interactors, revamped data downloads page and molecular structure viewers, gene burden data from the Broad CVDI ...

blog.opentargets.org

Very excited to share the latest work of the team @opentargets.org. If you are interested in #targetdiscovery and #genetics check out the latest release of the Open Targets Platform.

Open Targets@opentargets.org · 2y ago

Open Targets Platform 25.03 is finally here! 🌼 This update brings in variant, study, and credible set information, uniting the Open Targets Platform and Open Targets Genetics into a one-stop shop for human genetic and target discovery information. blog.opentargets.org/open-targets...

What can we learn from 95 projects across 10 years of industry-academic collaboration? 🤝 In a comment for Nature Reviews Drug Discovery, the Open Targets Directors shared their insights on what makes a successful and impactful project 🧪🧬 www.nature.com/articles/d41...

We're hiring! 👩‍🔬🧬💻 ➡ Staff Scientist: high-throughput sc CRIPSR screening in neurodegenerative disease ➡ Data Manager (part time), the point of contact for Open Targets project data ➡ Postdoc: Neurodegenerative Disease Immune Response Modelling opentargets.org/jobs #neurojobs #sciencejobs

With the gget opentargets module, you can now interact directly with the Open Targets database from a Python or command line environment Developed by @lauraluebbert.com, gget is a free, open-source tool enabling efficient querying of large genomic databases 🖥️🧬 blog.opentargets.org/case-study-g...

Case study: gget’s new Open Target module

The new gget opentargets module allows users to communicate directly with the Open Targets database from a Python or command line environment. Amongst other tasks, gget opentargets can quickly find di...

blog.opentargets.org

🗞️New preprint! Maria Falaguera developed a method to comprehensively track the accumulation of literature-derived, genetic and clinical evidence linking targets to disease over time, and to identify novel drug target opportunities 🧬🖥️ www.researchsquare.com/article/rs-5...