The best longevity drug available today is exercise and building muscle 💪

Your future health isn’t determined by your birthday. It’s determined by what you repeatedly do between now and then 💪

@lifebiosciences has confirmed the first patient has been dosed with an epigenetic restoration drug candidate. Exciting milestone 🚀 Life Biosciences is the OG cellular rejuvenation company, using epigenetic restoration to reverse diseases of aging lifebiosciences.com/life-bioscie...

The body responds to intensity more than duration. Even ~4.4 minutes of vigorous daily movement associates with ~26–30% lower mortality risk join.lifespan.com/577uh3zr

Association of wearable device-measured vigorous intermittent lifestyle physical activity with mortality - Nature Medicine

Using data from wearable activity monitors, this study shows that short bursts of physical activity that are done as part of daily life activities and that are only 1 or 2 minutes in length are…

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Aging is noise in the system and noise can be reduced

The question is not whether we age but how fast

Cells respond to mild adversity by becoming stronger

The more stable the system the slower the aging

Aging is a drift away from optimal gene expression

Longevity comes from maintaining order in complex systems

Cells do not forget how to be young, they lose access

The genome largely stays intact. What changes is how it is read

Biological clocks are entering the medical mainstream

The body is always responding to adversity and abundance

Cells are resilient until pushed past repair capacity

If aging is corrupted software, it can be reprogrammed

Every system in the body is adapting all the time. You are in control

Biology is not just chemistry, it is code

The body remembers youth even when it looks old

Aging is loss of information and the surprising finding is information can be restored

From 2008-2024 I was accused of hyping (a common slur) for suggesting that changes to the epigenome might cause aging and that therapeutics could "allow us to reset the epigenome to a more youthful state." - Oberdoerffer & Sinclair (2009) Success has many fathers, while failure is an orphan

Most people wait for disease.
By then, biology has already shifted

Type 2 diabetes is associated with substantially higher mortality risk www.nejm.org/doi/full/10....

Diabetes Mellitus, Fasting Glucose, and Risk of Cause-Specific Death | NEJM

The extent to which diabetes mellitus or hyperglycemia is related to risk of death from cancer or other nonvascular conditions is uncertain. We calculated hazard ratios for cause-specific death, ac...

nejm.org

Higher omega-3 levels are linked to ~15–20% lower mortality risk. More here: www.nature.com/articles/s41...

Biology doesn’t care what’s “normal.”
It responds to signals. And it can be changed

Muscle mass is a stronger predictor of survival than BMI in older adults Read here: www.sciencedirect.com/science/arti...

Prevention is delayed treatment of aging

The goal isn’t longer life.
It’s longer function and performance. Longer life is the side effect

The earlier you intervene, the bigger the payoff

About 7,000 steps/day is associated with ~50–70% lower mortality vs low activity jamanetwork.com/journals/jam...

Steps per Day and All-Cause Mortality in Middle-aged Adults

This cohort study assesses the association of step volume and intensity with premature all-cause mortality among Black and White participants in the Coronary Artery Risk Development in Young Adults…

jamanetwork.com