David Steensma, MD

@davidsteensma.bsky.social

Hematologist-oncologist. Ajax Therapeutics CMO. Former Edward P. Evans Chair in #MDSsm at #DanaFarber; #HarvardMedicalSchool & #MayoClinic faculty, #Novartis global hematology head. @DavidSteensma

A small stream runs through the woods behind our house, and this morning “frost flowers” were on the surface.❄️ I’ve never seen them before! They can form on thin ice on chilly, windless days when the air is much colder than the surface ice. Water vapor rising up from the surface quickly refreezes.

Frost flowers on thin ice.

I was walking along a trail yesterday and noticed this Madagascar periwinkle (Catharanthus roseus) - the plant that “vinca alkaloid” anti-cancer drugs vincristine and vinblastine were isolated from back in 1961. They’re still used today, especially vincristine for acute lymphoid leukemia and NHL.

Bild

Thought this was interesting: correlation between spleen length by palpation on physical exam in myelfibrosis versus spleen volume by centrally reviewed radiographic imaging, from a clinical trial described at #ASH24 by John Mascarenhas. There's a trend, but exam is not a super accurate measurement.

Bild

The late-breaking abstract session in on-demand video form also makes great "background music" while packing up in your hotel room #ASH24

American Society of Hematology@ash.hematology.org · 2y ago

The late-breaking abstracts — substantive, novel, and groundbreaking #hematology data that were not available by the general abstract submission deadline — are now being presented at #ASH24! Read the ASH press releases: bit.ly/3D5vLE5 #HemeSky

Over the holiday I read this epic 1955 book by famous naturalist & field guide pioneer Roger Tory Peterson & British ornithologist James Fisher about their 30,000 mile journey around North America in 1953, exploring from Newfoundland to the Dry Tortugas, from the Channel Islands to the Pribilofs./1

Bild

M31/Andromeda, with a cameo from M110. Not bad for Bortle 6-7 skies (suburban Boston), with only a 50mm lens and 2MP CMOS sensor - the S50’s newish mosaic mode is really cool, and minimizes field rotation effect from the alt-az mount. Processed in Siril & GraXpert.

Bild

Photo 1: California Nebula/NGC1499, 800x 10s subs with S50, processed in GraXpert and Siril, Bortle 6 sky. Photo 2: also California Nebula, this time with labels. 😀 If only ξ Persei/Menkib were slightly closer, it would be perfect for Vegas to be represented by a disproportionately bright star.

BildBild

This was my first attempt to make an educational #HemSky hematology thread on Bluesky. It seems to work…so-so. Links take up more space, and the thread (23 small posts) got broken up in a way that doesn’t happen on X/Twitter. Will keep working on it - maybe it will be fixed in future updates.

David Steensma, MD@davidsteensma.bsky.social · 2y ago

Hematologists & pathologists find these cells fascinating: ring sideroblasts. While most commonly associated with #MDS or inherited genetic disorders like #XLSA or #MLASA, these cells can also result from ethanol or tuberculosis drugs - even hypothermia. They have such an interesting history!/1

Ring sideroblasts (Prussian blue reaction) in a bone marrow aspirate.  Image source: @ash-hematology.bsky.social Image Bank

Hematologists & pathologists find these cells fascinating: ring sideroblasts. While most commonly associated with #MDS or inherited genetic disorders like #XLSA or #MLASA, these cells can also result from ethanol or tuberculosis drugs - even hypothermia. They have such an interesting history!/1

Ring sideroblasts (Prussian blue reaction) in a bone marrow aspirate.  Image source: @ash-hematology.bsky.social Image Bank

What is this guy that showed up in the backyard, #BirdSky? Juvenile red-shouldered hawk, or a Cooper’s hawk? iNaturalist Seek app thinks it is a broad-winged hawk, but I don’t think that’s likely; Merlin gave all 4 hawks in this area (suburban Boston) as possible options, including red-tailed.

Juvenile hawk perched on a weather sensor.BildBild