Check out our the structure of a DNA-guided Cas12a. It uses the DNA hairpin to mimic structural cues to recognize a target RNA. Gnarly. www.biorxiv.org/content/10.6...

Great work by @kaitlynakiernan.bsky.social! Glad we had her in our group before she moved on to her next adventure!!

Kaitlyn Kiernan@kaitlynakiernan.bsky.social · last yr.

Settling into summer with a deep dive into the conformational landscape of a multi-turnover Cas9. Happy to see my work with @davidwtaylorjr.bsky.social out in full form. Sneak peek of one (of many) structures below. Link to the full story here: rdcu.be/euifk

Fabulous grad student Grace Hibshman has solved the structure of FnCas9 with its scaRNA to show how it switches roles to transcriptional repression by bypassing nuclease activation. Check out her talk at CRISPR2025 in NZ! www.biorxiv.org/content/10.1...