Debby van Riel
@debbyvanriel.bsky.social
Associate Professor ○ Viroscience ○ Erasmus MC ○ The Netherlands Virology • Influenza • Enterovirus • SARS-CoV-2 • Pathogenesis • neuropathogenesis • Pathology • WomeninSTEM
See also the comment by Jessica Belser (@jessbelser.bsky.social): "A pandemic toolbox for clade 2.3.4.4b A(H5N1) influenza virus risk assessment": www.thelancet.com/journals/lan...
A pandemic toolbox for clade 2.3.4.4b A(H5N1) influenza virus risk assessment
Since 1997, more than 1000 cases of highly pathogenic avian influenza A(H5N1) have been reported in humans.1 During this time, A(H5N1) viruses have evolved into dozens of clades, showing ever-expandin...
thelancet.com
Current H5N1 avian influenza viruses replicate better in human respiratory tissues than a historic one, warranting "the urgency to prevent cross-species transmission to humans by controlling spillover events to mammals and limiting viral spread in farmed mammals." www.thelancet.com/journals/lan...
Excited to share that our mansucript is finally published! Check it out here: www.thelancet.com/journals/lan...
Attachment and replication of clade 2.3.4.4b influenza A (H5N1) viruses in human respiratory epithelium: an in-vitro study
Clade 2.3.4.4b H5N1 viruses have phenotypic characteristics that are different from a clade 2.1.3.2 H5N12005 virus. The ability of clade 2.3.4.4b viruses to attach to and replicate in respiratory epit...
thelancet.com
Check out the new publication of Viruses like it 🍬🍭! @lisabauervirus.bsky.social and @debbyvanriel.bsky.social investigated the clade 2.3.4.4b A(H5N1) influenza virus attachment and replication in human respiratory epithelium! Congratulation to all involved!
Lisa Bauer@lisabauervirus.bsky.social · 8mo agoExcited to share that our mansucript is finally published! Check it out here: www.thelancet.com/journals/lan...
And now published! #glycotime "Sialic Acid-Containing Glycolipids Extend the Receptor Repertoire of Enterovirus-D68" fantastic collaboration with @lisabauervirus.bsky.social @debbyvanriel.bsky.social @TheBoonsGroup enjoy 👍https://pubs.acs.org/doi/10.1021/acsinfecdis.5c00063
We are happy to share the first publication of our consortium: pubs.acs.org/doi/10.1021/...
Sialic Acid-Containing Glycolipids Extend the Receptor Repertoire of Enterovirus-D68
Enterovirus D68 (EV-D68) emerged as a pathogen of increasing health concern globally, particularly due to its association with outbreaks of severe respiratory diseases and acute flaccid myelitis (AFM) in children. Knowledge regarding the tissue tropism and pathogenesis of EV-D68 within the respiratory tract and central nervous system remains limited, primarily due to an incomplete understanding of the host factors that facilitate the entry of EV-D68 into host cells. Several cellular receptors involved in EV-D68 infections have been identified, including ICAM-5, sialylated glycoproteins, and heparan sulfate (HS). Here, we investigate the receptor requirement of a panel of EV-D68 strains covering all clades, focusing on HS and sialosides utilizing glycan arrays. We found that all EV-D68 strains binding to HS harbor a cell culture adaptive substitution in the structural protein VP1 at position 271, which changes the amino acid into a positively charged one. Glycan array analyses revealed that EV-D68 strains prefer α2,6-linked sialic acids presented on N-glycans, α2,8-linked sialic acids on gangliosides, or both. Inhibition of glycolipid biosynthesis or multivalent glycolipid mimics confirmed that ganglioside structures serve as entry receptors for certain EV-D68 strains. Lastly, we examined whether EV-D68 strains that bind to HS or glycolipids require different uncoating mechanisms. Bafilomycin A1 minimally affected the cell entry of HS-binding EV-D68 strains B2/039 and B2/947, and the ganglioside preferring B1/2013 and other viruses were strongly inhibited. Together, we identified that EV-D68 strains can use disialoglycolipids as novel receptors and that different EV-D68 strains show a promiscuous sialic acid binding repertoire.
pubs.acs.org
Check out this amazing documentary from our PI @debbyvanriel.bsky.social discussing the potential of a bird flu as the next pandemic!
Debby van Riel@debbyvanriel.bsky.social · last yr.This documentary covers the current bird flu situation. Clearly presented, realistic and where necessary with nuance. Interviews by Neil Cairns & team with @linekebegeman.bsky.social, Tom Frieden, @jw132.bsky.social, Jim Paulson and myself. www.youtube.com/watch?v=F5XK...
The Razor Science Show provides cutting-edge science and technology stories, including the documentary "Bird flu - the next pandemic?". Neil Cairns interviews @drtomfrieden.bsky.social , @jw132.bsky.social, @linekebegeman.bsky.social, and @debbyvanriel.bsky.social. www.youtube.com/watch?v=F5XK...
Bird flu - the next pandemic?
YouTube video by RAZOR Science Show
youtube.com
This documentary covers the current bird flu situation. Clearly presented, realistic and where necessary with nuance. Interviews by Neil Cairns & team with @linekebegeman.bsky.social, Tom Frieden, @jw132.bsky.social, Jim Paulson and myself. www.youtube.com/watch?v=F5XK...
Bird flu - the next pandemic?
YouTube video by RAZOR Science Show
youtube.com
Excited to have this story out on bioRxv! #glycotime #lovevirology #H5N1 The receptor binding properties of H5Nx influenza A viruses have evolved to promiscuously bind to avian-type mucin-like O-glycans. www.biorxiv.org/content/10.1...
The receptor binding properties of H5Nx influenza A viruses have evolved to promiscuously bind to avian-type mucin-like O-glycans
Highly pathogenic H5Nx influenza A viruses are causing unprecedented, season-independent outbreaks across avian and mammalian species, including dairy cattle, a novel reservoir. The sialoside-binding ...
biorxiv.org
We a looking for a Postdoc! Interested in virology, stem-cell derived models, glycans? Apply before 29th of October! @thijskuiken.bsky.social @lisabauervirus.bsky.social @marionkoopmans.bsky.social @rpdevrieslab.bsky.social www.werkenbijerasmusmc.nl/en/vacancy/1...
Vacature: Postdoc Virology
The department of Viroscience at the Erasmus MC and the department of Chemical Biology & Drug discovery at Utrecht University have joined forces to identify functional glycan receptors for influenza A...
werkenbijerasmusmc.nl
Looking for a PhD position? Interested in viruses, stem cell-derived models and/or glycans? Ready to work in a multidisciplinary teams other amazing scientists? Apply now 👇 www.werkenbijerasmusmc.nl/en/vacancy/1...
Vacature: PhD position Virology
The department of Viroscience at the Erasmus MC and the department of Chemical Biology & Drug discovery at Utrecht University have joined forces to identify functional glycan receptors for influenza A...
werkenbijerasmusmc.nl
#Viruseslikeitsweet is online! We are a consortium of the department of Viroscience @erasmusmc.bsky.social and the department of Chemical Biology & Drug discovery @utrechtuniversity.bsky.social Follow our progress here or via our Linked-In account: NWO-XL Consortium Viruses like it Sweet
Looking for a PhD position? Interested in viruses, stem cell-derived models and/or glycans? Ready to work in a multidisciplinary teams other amazing scientists? Apply now 👇 www.werkenbijerasmusmc.nl/en/vacancy/1...
Vacature: PhD position Virology
The department of Viroscience at the Erasmus MC and the department of Chemical Biology & Drug discovery at Utrecht University have joined forces to identify functional glycan receptors for influenza A...
werkenbijerasmusmc.nl
Online now! Neuroinvasive and neurovirulent potential of SARS-CoV-2 in the acute and post-acute phase of intranasally inoculated ferrets. Here we reveal subtle changes in the brain of SARS-CoV-2 infection in ferrets, which developed only MILD disease. dx.plos.org/10.1371/jour... 1/n
Neuroinvasive and neurovirulent potential of SARS-CoV-2 in the acute and post-acute phase of intranasally inoculated ferrets
Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) can cause systemic disease, including neurological complications, even after mild respiratory disease. Previous studies have shown that SA...
dx.plos.org
Are you (or anyone you know) ambitious, interested in the pathogenesis of arboviruses and ready for Rotterdam? If yes, check out this vacancy for an assistant professor position 👇. More opportunities to join Viroscience will follow soon, so stay tuned 😀
Marion Koopmans@marionkoopmans.bsky.social · last yr.Please share with people interested in arbovirology. We are looking for an enthusiastic colleague to strengthen our team please share if you know of scientists interested in arbovirology, ready to make a move to Rotterdam! www.academictransfer.com/en/jobs/3508...
The UK’s Chief Veterinary Officer has confirmed a case of highly pathogenic avian influenza (H5N1) in a single sheep in Yorkshire following repeat positive milk testing. To my knowledge, this is the first time the virus has been detected in sheep. www.gov.uk/government/n...
Influenza of avian origin confirmed in a sheep in Yorkshire
Influenza of avian origin (H5N1) has been confirmed in a single sheep in Yorkshire.
gov.uk
In normal times, I'd have written about this #MMWR report about some of the kids who've died from #flu this year having had a severe neurological condition called influenza-associated encephalopathy or encephalitis. Glad to see @cidrap.bsky.social did write! www.cidrap.umn.edu/influenza-ge...
CDC: 13% of kids who died from flu this year had brain damage
cidrap.umn.edu
📣 New #ESWIAirborne: #hMPV - the (not so) new kid on the block. Learn about the story behind #humanmetapneumovirus and how it was first discovered, featuring: Albert Osterhaus, Bernadette van den Hoogen & Ann Falsey! #ESWIEducationHub shorturl.at/yszOv
Intervention Strategies: hMPV - the (not so) new kid on the block | ESWI
Learn about the fascinating story behind the intriguing Human metapneumovirus (hMPV) and how it was first discovered.
shorturl.at
This is a call for signatories to speak up against the ongoing attack on science by the new US government. Feel free to share docs.google.com/document/u/0...
Declaration To Defend Research Against Government Censorship
Declaration To Defend Research Against U.S. Government Censorship, V.1.1 Drafted by Lisa Schiff (@lschiff.bsky.social), Alice Meadows (@alicemeadows.bsky.social), Catherine Mitchell (@camitchell.bsky....
docs.google.com
"This is not a fight we can afford to lose." No, because losing literally means millions of dead people. My fellow Americans, it is time to muster your courage and speak up.
Prof Gavin Yamey MD MPH@gavinyamey.bsky.social · last yr.An absolutely scorching OpEd by Harold Varmus, Nobel laureate, on Trump's destruction of the vaunted US scientific & biomedical enterprise & on Trump's kooky picks to lead the US health & science agencies Gift link to share far & wide www.nytimes.com/2025/02/14/o...
Onderzoeker en viroloog John van der Oost wint de #Beijerinck #Virologie Prijs voor zijn CRISPR-Cas onderzoek. Early career onderzoekers Carmen Embregts & Puck van Kasteren ontvangen de #BeijerinckPremie. www.knaw.nl/nieuws/voorb... @rdo-erasmusmc.bsky.social @rivm-nl.bsky.social @w-u-r.bsky.social
Have you heard of the Matilda Effect? When the work of female scientists is credited to a man🧪 Today is International Day of Women and Girls in Science, so here are five victims of the Matilda effect: (Add your favourite forgotten #womeninSTEM to this list!👩🔬)
The abstract submission is open for ESCV 2025. Would love to see you there. www.linkedin.com/posts/europe...
European Society for Clinical Virology on LinkedIn: 🔊Registration and Abstract Submission open The 27th ESCV Annual Meeting…
🔊Registration and Abstract Submission open The 27th ESCV Annual Meeting is officially under way! 🚨Abstract Submission Deadline: 12 May 2025 🚨Early Bird…
linkedin.com
For the second time transmission of H5N1 virus to cows detected 🤔
Kristian G. Andersen@kgandersen.bsky.social · last yr.Genotype D1.1 of H5N1 confirmed in Nevada cattle, which is the one circulating in birds and not B3.13, causing the wider cattle epizootic in the U.S. In other words, this is a second observed jump from birds into cows. Keep rolling the dice, shall we? www.feedstuffs.com/agribusiness...
Can #birdflu become airborne? Scientists were slow to recognize that #Covid spreads through the air. Some researchers are now trying to get ahead of avian influenza www.nytimes.com/2025/02/03/s...
Could the Bird Flu Become Airborne?
Scientists were slow to recognize that Covid spreads through the air. Some are now trying to get ahead of the bird flu.
nytimes.com
Our study on pasteurising influenza viruses in milk is now out! It's a nice simple story: influenza viruses (including H5N1) are killed really effectively by pasteurisation, but in raw milk they stay infectious - obvious public health implications of both points... (1/2) rdcu.be/d73te
If you're a non-UK scientist who wants to come to the UK for a postdoc, this year's Newton Fellowships are now open. You'll need a lab to host you (which could be me, but truly, could be any PI, so get in touch with someone you'd like to work with!) royalsociety.org/grants/newto...
Newton International Fellowships | Royal Society
This fellowship is for non-UK scientists who are at an early stage of their research career and wish to conduct research in the UK.
royalsociety.org
In recente dagen is weer een toename gezien in het aantal zieke en dode wilde vogels, vooral brandganzen, door hoog-pathogene vogelgriep. Het melden van dode vogels kan o.a. via de websites van het DWHC (dwhc.nl/meldingsform...) en Sovon (portal.sovon.nl/dood). www.sovon.nl/actueel/nieu...
