🎙️ Episode 31 is now live! This week, Dr. Raghav Sehgal and Dr. Macsue Jacques welcome Associate Professor Daniel W. Belsky from the Columbia University Mailman School of Public Health for a fascinating conversation on the science of measuring the pace of aging.

"People are diving in on rapamycin in the absence of almost any useful evidence." Professor Richard A. Miller (University of Michigan) discusses why evidence—not enthusiasm—should guide longevity interventions. Hear the full conversation with Raghav Sehgal and Dr. Macsue Jacques. #Longevity

"The public thinks aging is immutable. They're wrong." Professor Richard A. Miller (University of Michigan) explains why this belief may be holding back progress in aging research. Hear the full conversation with Raghav Sehgal and Dr. Macsue Jacques in Episode 30 of Decoding Longevity. #Longevity

"Healthspan is an awful term." Why would Professor Richard A. Miller (University of Michigan) say that? In Episode 30 of Decoding Longevity, Raghav Sehgal and Dr. Macsue Jacques explore why one of longevity science's most common terms deserves a closer look. #Longevity

🎙️ New episode! Raghav Sehgal and Dr. Macsue Jacques talk with Professor Richard A. Miller (University of Michigan) about how scientists test whether longevity interventions really slow aging. From rapamycin to biomarkers and replication, it’s evidence over hype. Listen now! #Longevity

What if the next frontier in HIV care isn't just helping people live longer—but helping them age healthier? Professor Linda-Gail Bekker discusses accelerated biological aging in people living with HIV and why protecting healthspan is just as important as extending lifespan. 👇

What if longevity isn't measured by how long we live, but by how well we live? Professor Linda-Gail Bekker from the Desmond Tutu HIV Centre reminds us: “Longevity is more than just lifespan. It's about healthspan—helping people live longer, healthier lives.” 👇

After a short break, a new episode of Decoding Longevity is out 🎧

What if some of the answers to neurodegeneration are hidden in hibernation? Hibernating mammals repeatedly develop and clear tau phosphorylation while rebuilding neuronal connections. A fascinating insight from Dr. Ashley Zehnder of Fauna Bio on Decoding #Longevity. #Neuroscience #Alzheimers 👇

What if evolution has already solved problems we're still trying to fix? A fascinating perspective from Dr. Ashley Zehnder of Fauna Bio on Decoding Longevity with Dr. Raghav Sehgal and Dr. Macsue Jacques. #Longevity #ComparativeBiology #FaunaBio

What happens when sequencing becomes cheap enough to study nature's most extraordinary species at scale? According to Dr. Ashley Zehnder of Fauna Bio, we're entering a new era of comparative biology—one that could transform drug discovery and longevity science. #AshleyZehnder #FaunaBio 👇

Hibernation may be one of nature’s most powerful regenerative programs. How do hibernating mammals survive extreme physiological stress without fibrosis, muscle loss, or neurodegeneration? Dr. Ashley Zehnder of Fauna Bio explores the answer on Decoding Longevity. #Longevity #AshleyZehnder #FaunaBio

What if the answers to aging aren't in humans—but in animals that have already solved these problems? In Episode 28 of Decoding Longevity, Dr. Ashley Zehnder (Co-Founder & CEO, Fauna Bio) joins hosts Dr. Raghav Sehgal and Dr. Macsue Jacques 👇

What if evolution has already solved some of the biggest challenges in medicine? In Episode 28 of Decoding Longevity, Dr. Ashley Zehnder (Co-Founder & CEO, Fauna Bio) joins hosts Dr. Raghav Sehgal and Dr. Macsue Jacques to explore how 👇

What if the most powerful longevity interventions are the ones we already know? In this clip from Decoding Longevity, Dr. Eric Verdin (@buckinstitute.org) explains why exercise, nutrition, sleep, stress management, and purpose remain essential for healthy aging.

What if aging is partly driven by an immune system that never gets the signal to stand down? Dr. Eric Verdin on "inflammaging": "Inflammaging reflects what happens when a normally protective immune response becomes chronically activated." Hosted by Dr. Raghav Sehgal & Dr. Macsue Jacques.

What if aging is not just decline — but a biologically regulated process? In our latest Decoding Longevity episode, Dr. Eric Verdin explains how metabolism, nutrient sensing, inflammation, NAD+, and epigenetics may shape how we age. 👇

Our latest Decoding Longevity episode is now live. This week, we’re joined by Dr. Eric Verdin, President & CEO of the Buck Institute for Research on Aging, for a deep discussion on metabolism, immune aging, inflammation, epigenetics, and the future of longevity science.

“The goal isn’t living forever. It’s reducing the years we spend unhealthy.” — Dr. Janine Sengstack Dr. Janine Sengstack joins Dr. Raghav Sehgal and Dr. Macsue Jacques on Episode 26 of Decoding Longevity to discuss RNA therapeutics, AI-driven biology, and the future of cell reset therapies.

What if aging isn’t damage… but misregulation? Episode 26 of Decoding Longevity, hosted by Raghav Sehgal and Macsue Jacques, with Dr. Janine Sengstack. We explore “Cell Reset Therapeutics” — a shift from replacing cells to restoring their function.

In Episode 26 of Decoding Longevity, Dr. Janine Sengstack explains how siRNA therapeutics could make “undruggable” transcription factors targetable. A fascinating conversation with Dr. Raghav Sehgal and Dr. Macsue Jacques on RNA medicine and longevity biotech.

Why do humans treat aging and death as if they are inherently “good” or “necessary”? In this episode, Raghav Sehgal and Macsue Jacques speak with Dr. Raiany Romanni-Klein about how cultural and moral narratives shape longevity science. 👇

“Nature is ruthless.” In this episode, Raghav Sehgal and Macsue Jacques speak with Dr. Raiany Romanni-Klein about why the belief that “natural = good” may be limiting progress in longevity science. 👇

We’ve become very good at talking to ourselves in this field—but not at driving real progress. A sharp reflection on the state of longevity research. In this episode, Raghav Sehgal and Macsue Jacques speak with Dr. Raiany Romanni-Klein about the structural and cultural challenges slowing the field.

What if the future of longevity is shaped not just by science—but by the stories we tell about aging? In this episode, Raghav Sehgal and Macsue Jacques speak with Dr. Raiany Romanni-Klein about the ethical and economic forces shaping aging research. 🎧 Listen Spotify: open.spotify.com/episode/2l9Y...

A new episode of Decoding Longevity is now live. Raghav Sehgal and Macsue Jacques are joined by Dr. Raiany Romanni-Klein (AFAR) to explore how ethics, economics, and cultural narratives shape the future of aging science. Thank you, Raiany, for a thoughtful and important conversation.

We’re not building a new model for aging. We’re using the same clinical model—on a new target. That target is aging itself. In this episode, Raghav Sehgal and Macsue Jacques speak with Dr. Michael Ringel about what this shift really means. 🎧 Listen: Spotify: open.spotify.com/episode/4Glm... 👇

What if aging could be rewritten? Raghav Sehgal opens this episode with a powerful idea—followed by a deep dive with Macsue Jacques and Dr. Michael Ringel (Life Biosciences). From theory to human trials.

🚨 What if aging isn’t something we just accept — but something we can reprogram? A new episode of Decoding Longevity is now live.

You don’t “suddenly” get old. You gradually lose reserve—until something breaks. In this episode, Stephen Kritchevsky joins Raghav Sehgal and Macsue Jacques to explain how physiological reserve decreases over time, often unnoticed—until a fall, fracture, or loss of function occurs.