How does a geminivirus replicate its genome using a pick&mix strategy with host proteins? 🦠🦠🌱🧬 Our new preprint identifies plant proteins repurposed by geminiviruses to carry out rolling-circle replication. Congrats @chaonan123.bsky.social , who spearheaded this work! www.biorxiv.org/content/10.6...
Delphine Pott
@delphinem-p.bsky.social
Postdoc in @geminiteamlab.bsky.social, ZMBP, Uni Tübingen. Previous Humboldt & Marie Sklodowska fellow. RNA splicing in plant developmental/environmental responses
In our recent review, we explore how the spliceosome is targeted by effectors from diverse plant-interacting organisms—and how these effectors can serve as powerful molecular probes to uncover the mechanisms of splicing regulation in plants. @geminiteamlab.bsky.social #PlantScience #RNA #Splicing
New insights into microbial manipulation of the plant spliceosome
Abstract. Alternative splicing (AS) has emerged as a regulatory layer in plant adaptation to the environment. In particular, biotic stresses trigger a dras
academic.oup.com
RNA splicing generates a functionally specialized Rep protein isoform in geminiviruses — enabling timely control of the viral cycle. Strikingly, similar strategies might have evolved in DNA viruses infecting different kingdoms: www.biorxiv.org/content/10.6... Spearheaded by @delphinem-p.bsky.social!
📋 Join us on Friday 19th for a fascinating talk by Rosa Lozano-Durán from Center for Molecular Plant Biology (ZMBP), University of Tübingen (Germany) @unituebingen.bsky.social as part of the #IHSMLaMayoraSeminars series Don't miss it! 🕑 9:30 AM 📍 IHSM La Mayora Auditorium More information here ⬇️
It was so nice to visit @mpi-mp-potsdam.bsky.social! Lots of #virus and #RNA discussions. Thanks @incavirus.bsky.social for the invitation!
Great talk by @delphinem-p.bsky.social from @geminiteamlab.bsky.social yesterday: “Hijacking the Plant #Spliceosome” on how alternative splicing drives #viral infection and #tomato fruit development 🍅 Thanks to our host @incavirus.bsky.social for organizing this insightful seminar! 👏
Splicing was discovered in adenoviruses, but was thought to be only anecdotal in plant viruses... We may need to revisit plant viral transcriptomes and proteomes!
How do geminiviruses maximize their limited coding capacity? Our recent preprint uncovers splicing of viral transcripts as one more strategy used by this viral family. We show that RNA splicing is prevalent in the geminivirus TYLCV — and required for infectivity! www.biorxiv.org/content/10.1...
Incredibly happy and proud of our Chaonan Shi (chaonan123.bsky.social ), who successfully defended her doctoral thesis yesterday at the @zmbp-tuebingen.bsky.social ! (And what a brilliant defence it was!) 🥳🥳🥳 Congratulations, Dr Shi!!! 🍾🥂🍋🟩🌶️ We are so lucky to have you in our team ❤️
How do plant viruses cause symptoms? Are these developmental alterations functionally relevant? Man Gao, Enmanuel, et al. found that TYLCV does so through a host-mimicking domain in its C4 protein, co-opting a plant protein family - to attract the insect vector! www.sciencedirect.com/science/arti...
A plant virus causes symptoms through the deployment of a host-mimicking protein domain to attract the insect vector
Plant viruses cause symptoms with devastating consequences for agriculture. However, the molecular mechanisms underlying symptom development in viral …
sciencedirect.com