Most of neuromodulation is trial and error resulting in slow progress over many decades. Check out this cool work using understanding of neural dynamics to drive the circuit using targeted stimulation.

Roozbeh Kiani@roozbehkiani.bsky.social · 6mo ago

Can electrical microstimulation be used to steer cortical population activity on- and off-manifold? Our new preprint says yes — using data-driven control in macaque PFC. Joint work with @gbarzon.bsky.social, Anandita De, Isaac Moran, Conner Carnahan, and Luca Mazzucato.

The basal ganglia output is often framed as a motor gate: corticostriatal circuits select an action, then GPi/SNr-thalamus helps release it. In humans, we find this same pathway carries cognitive variables embedded in movement signals—and even produces learning-relevant signals after feedback. 1/10