Dermatology Advisor
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Women with androgenetic #alopecia who received spironolactone had greater improvement in Sinclair grades from baseline to month 24 than those treated with bicalutamide. Read more: https://www.dermatologyadvisor.com/news/spironolactone-outperforms-bicalutamide-androgenetic-alopecia-women/
The mean change in Teoxane Midface Volume Deficit Scale scores from baseline to 8 weeks was -1.3 with RHA4 and -1.3 with an approved active comparator. Read more: https://www.dermatologyadvisor.com/news/rha4-effective-active-comparator-midface-volume-deficiency/
RHA4 Is as Effective as an Active Comparator for Midface Volume Deficiency
The use of RHA4 is equivalent to that of an approved, active comparator for the treatment of midface volume deficiency through 52 weeks.
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Significant differences in neutrophil-to-monocyte ratio and neutrophil-to-lymphocyte ratios were noted in some groups with #rosacea. Read more: https://www.dermatologyadvisor.com/news/high-nmr-levels-linked-ocular-involvement-rosacea/
High NMR Levels May Be Linked to Ocular Involvement in Rosacea
Out of all of the hematological parameters examined, only neutrophil-to-monocyte ratio was associated with ocular involvement in rosacea.
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In children with moderate to severe #AtopicDermatitis, 62% of boys and 48% of girls were below the 50th percentile for height, whereas 50% and 51%, were above the 50th percentile for weight. https://www.dermatologyadvisor.com/news/moderate-severe-atopic-dermatitis-linked-reduced-growth-children/
Moderate to Severe Atopic Dermatitis Is Linked to Reduced Growth in Children
Pediatric patients with moderate to severe AD may have a reduced mean height and increased mean weight when compared with the general population.
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Women with severe #acne vulgaris have imbalances in sex hormones and oxidative stress profiles compared with those without acne vulgaris. https://www.dermatologyadvisor.com/news/severe-acne-vulgaris-women-linked-hormone-imbalances-oxidative-stress/
Severe Acne Vulgaris In Women Linked to Hormone Imbalances, Oxidative Stress
Significant imbalances in sex hormones and oxidative stress were seen among women with severe acne vulgaris when compared with healthy controls.
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In patients with hidradenitis suppurativa-related pain, oxycodone was the most-prescribed opioid in the emergency department; hydrocodone was most prescribed in ambulatory settings. https://www.dermatologyadvisor.com/news/opioid-prescribing-for-hs-pain-is-significantly-more-likely-in-the-ed/
Opioid Prescribing for HS Pain Is Significantly More Likely in the ED
Patients with HS who present to the emergency department vs ambulatory care for pain are significantly more likely to be prescribed opioids.
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The combination of laser and intralesional #triamcinolone to treat pathological scars was associated with improvements in Vancouver Scar Scale & modified-Vancouver Scar Scale scores. https://www.dermatologyadvisor.com/news/laser-plus-triamcinolone-improves-pathological-scars-more-than-laser-alone/
Laser Plus Triamcinolone Improves Pathological Scars More Than Laser Alone
Laser therapy with intralesional triamcinolone was superior to laser monotherapy for hypertrophic scar, keloid, and post-burn scar treatment.
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The AI tools moving fastest in dermatology are often the least rigorously validated, while clinical tools are advancing more slowly due to practical concerns about implementation. Read more: https://www.dermatologyadvisor.com/features/ai-in-dermatology/
AI in Dermatology: Balancing Rapid Adoption With Careful Integration
Research is needed on the real-world performance of clinical AI tools in dermatology, yet many patients use available consumer-facing tools.
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Oral probiotic supplementation may improve skin hydration, reduce transepidermal water loss, and reduce wrinkle severity among healthy adults, https://www.dermatologyadvisor.com/news/early-results-show-oral-probiotics-may-improve-skin-hydration-barrier-function/
Early Results Show Oral Probiotics May Improve Skin Hydration, Barrier Function
Oral probiotic supplementation may be beneficial for skin hydration and barrier function, but additional research is needed.
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Rates of response to treatment for plaque #psoriasis was 70.1% with biologic therapies, 45.8% with methotrexate, and 54.7% with phototherapy. Read more: https://www.dermatologyadvisor.com/news/baseline-factors-associated-treatment-response-psoriasis-identified/
Baseline Factors Associated With Treatment Response in Psoriasis Identified
Baseline clinical factors that predict treatment response varied by the type of therapy utilized among patients with plaque psoriasis.
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Oral JAK inhibitors are associated with significantly increased rates of clinically meaningful hair regrowth compared with placebo in patients with moderate to severe #alopecia areata Read more: https://www.dermatologyadvisor.com/news/oral-jak-inhibitors-effective-moderate-severe-alopecia-areata/
Oral JAK Inhibitors Are Effective for Moderate to Severe Alopecia Areata
Results of a systematic review and meta-analysis confirm the efficacy and safety of oral JAK inhibitors for the treatment of alopecia areata.
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After 16 weeks of low-dose micronized #isotretinoin treatment, patients with severe recalcitrant nodular acne achieved a 84.41% reduction in Investigator’s Global Assessment scores. https://www.dermatologyadvisor.com/news/low-dose-micronized-isotretinoin-improves-severe-recalcitrant-nodular-acne/
Low-Dose Micronized Isotretinoin Improves Severe Recalcitrant Nodular Acne
Low-dose micronized isotretinoin was an effective and safe therapy option for severe recalcitrant nodular acne in real-world settings.
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Adherence to 4 healthy lifestyle behaviors was associated with a lower incidence of adult-onset #AtopicDermatitis when compared with those who adhered to 0 or 1 behavior. Read more: https://www.dermatologyadvisor.com/news/adherence-4-lifestyle-behaviors-may-lower-risk-incident-atopic-dermatitis/
Adherence to 4 Lifestyle Behaviors May Lower Risk for Incident Atopic Dermatitis
Adults who adhere to healthy habits regarding alcohol consumption, smoking cessation, sleep, and physical activity have a lower risk for incident AD.
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In the last decades, there have been strides to include women in clinical trials — after their exclusion until the 1990s. Why were women historically excluded from clinical trials and what still needs to be done? https://www.dermatologyadvisor.com/features/women-in-clinical-trials-history-impact/
Women in Clinical Trials: History and Impact
Women were generally excluded from clinical trials until the 1990s; in 1993, the NIH inclusion policy was codified into federal law.
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Top benefits of telemedicine in managing systemic therapies for #psoriasis & #AtopicDermatitis include cost savings for patients, whereas providing good service is among top benefits for providers. https://www.dermatologyadvisor.com/news/patients-providers-favorable-view-telemedicine-psoriasis-ad/
Patients, Providers Have Favorable View of Telemedicine for Psoriasis and AD
Both patients and health care providers regard the use of telemedicine for the management of systemic therapies for psoriasis and AD as positive.
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Among melanocytic lesions with peripheral globules at baseline, 46.9% of lesions had complete globule resolution at follow-up. Read more: https://www.dermatologyadvisor.com/news/longitudinal-melanocytic-lesion-patterns-guide-melanoma-risk-stratification/
Longitudinal Melanocytic Lesion Patterns May Guide Melanoma Risk Stratification
Longitudinal histopathologic patterns of melanocytic lesions may be used to improve risk stratification for melanoma and other adverse outcomes.
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At 2 years of treatment, 96.6% of those with moderate to severe #AtopicDermatitis reported meaningful benefit; 74.9% reported improvement in #pruritus relief — the highest rated priority. https://www.dermatologyadvisor.com/news/pruritus-relief-patients-top-treatment-priority-for-moderate-severe-ad/
Pruritus Relief Is Patients’ Top Treatment Priority for Moderate to Severe AD
Pruritus relief is the greatest treatment priority for those with moderate to severe AD, despite variations in priorities across patient subgroups.
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In the full-analysis population, 88.27% of those who received the lidocaine-premixed hyaluronic acid gel for nasolabial fold correction had improvements at 6 months. https://www.dermatologyadvisor.com/news/lidocaine-premixed-ha-gel-noninferior-option-nasolabial-fold-correction/
Lidocaine-Premixed HA Gel Is Noninferior Option for Nasolabial Fold Correction
A novel lidocaine-mixed HA gel was noninferior to an approved comparator for NLF correction among adults at 6 months post-treatment.
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Using the highest dose of #delgocitinib cream, 20 mg/g, was associated with a change in #Eczema Area and Severity Index scores of -7.6 at 8 weeks compared with -1.9 with cream vehicle. https://www.dermatologyadvisor.com/news/delgocitinib-cream-demonstrates-dose-dependent-efficacy-atopic-dermatitis/
Delgocitinib Cream Demonstrates Dose-Dependent Efficacy in Atopic Dermatitis
Delgocitinib cream has a significant dose-response relationship for achieving 75% improvement in EASI among patients with AD at 8 weeks.
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#Cidofovir cream and imiquimod 5% are associated with the lowest risks for adverse events among adults with external anogenital warts. Read more: https://www.dermatologyadvisor.com/news/anogenital-wart-treatments-significant-differences-tolerability/
A combined approach of dermoscopy with handheld reflectance confocal microscopy had a high confidence rate of 83% for the diagnosis of basal cell carcinoma. Read more: https://www.dermatologyadvisor.com/news/dermoscopy-with-hh-rcm-limits-unnecessary-diagnostic-biopsies-bcc/
Dermoscopy With HH-RCM Limits Unnecessary Diagnostic Biopsies for BCC
A combined approach with dermoscopy and HH-RCM significantly reduces the rate of unnecessary diagnostic biopsies in patients with suspected BCC.
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Among patients with #alopecia areata receiving #ritlecitinib, 61.1% of patients developed at least 1 treatment-emergent laboratory abnormality. Read more: https://www.dermatologyadvisor.com/news/laboratory-abnormalities-ritlecitinib-common-rarely-significant/
Laboratory Abnormalities With Ritlecitinib Are Common but Rarely Significant
Though laboratory abnormalities are common with ritlecitinib therapy for alopecia areata, the majority are mild and not clinically significant.
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Though some differences were noted across several scalp health parameters in women who used hijab vs those who did not, none of the differences were statistically significant. Read more: https://www.dermatologyadvisor.com/news/hijab-use-does-not-affect-scalp-biophysical-characteristics/
Hijab Use Does Not Affect Scalp Biophysical Characteristics
No significant differences were noted in the biophysical characteristics of the scalp in women who used hijab vs those who did not.
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At 12 weeks, 72.1% of patients with plaque #psoriasis who received #socrodeucitinib 12 mg and 28.6% who received 6 mg achieved at least a 75% reduction in Psoriasis Area and Severity Index scores. https://www.dermatologyadvisor.com/news/socrodeucitinib-effective-well-tolerated-plaque-psoriasis/
Socrodeucitinib May Be Effective and Well-Tolerated for Plaque Psoriasis
Socrodeucitinib significantly reduced PASI scores at 12 weeks of treatment among adults with moderate to severe plaque psoriasis.
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A skin biopsy can be performed to diagnose or rule out conditions such as skin cancer, inflammatory skin disorders, chronic rashes, infections, or unusual growths. Read our fact sheet on proper skin biopsy aftercare: https://www.dermatologyadvisor.com/factsheets/skin-biopsy-and-aftercare/
Skin Biopsy Wound Care: Proper Aftercare Steps for Patients
A skin biopsy is a common medical procedure in which a small sample of skin is removed for examination; aftercare can help reduce scarring.
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The median repigmentation rate among patients with stable #vitiligo at 12 months of treatment is 90% with ReCell cellular grafting and 60% with traditional tissue grafting techniques. https://www.dermatologyadvisor.com/news/cellular-grafting-superior-success-rate-some-patients-with-vitiligo/
Cellular Grafting Has Superior Success Rate in Some Patients With Vitiligo
Cellular grafting with ReCell results in superior repigmentation compared with standard tissue grafting in select populations with stable vitiligo.
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Among men with androgenetic #alopecia who were treated with topical #finasteride 0.25%, a total of 85% achieved at least a 1-point improvement on Physician’s Global Assessment from baseline at 52 weeks. https://www.dermatologyadvisor.com/news/topical-finasteride-0-25-improves-hair-growth-men-aga/
Topical Finasteride 0.25% Improves Hair Growth in Men With AGA
Topical finasteride 0.25% is safe and effective when administered through a commercial spray or compounded solution for men with AGA.
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Diagnosis with dermoscopy alone detected 54.8% of #LentigoMaligna and lentigo maligna melanoma lesions, whereas reflectance confocal microscopy integration detected 91.9% of lesions. https://www.dermatologyadvisor.com/news/integrating-reflectance-confocal-microscopy-aids-lm-lmm-diagnosis/
Integrating Reflectance Confocal Microscopy Aids LM/LMM Diagnosis
Integrating RCM improves the diagnostic sensitivity and specificity for lesions on the head and neck when compared with dermoscopy alone.
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Rates of simple incision and drainage, complicated incision and drainage & various wide local excision types for hidradenitis suppurativa treatment are lower in patients who received #GLP1RA. https://www.dermatologyadvisor.com/news/glp-1-ra-use-associated-fewer-surgeries-hidradenitis-suppurativa/
GLP-1 RA Use Is Associated With Fewer Surgeries for Hidradenitis Suppurativa
The use of GLP-1 RAs was associated with lower rates of surgical procedures performed among patients with HS when compared with control patients.
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At 180 days of treatment with hair growth #nutraceuticals, hair growth rates among women ranged from an 18.6% improvement to a 36.7% improvement. Read more: https://www.dermatologyadvisor.com/news/hair-growth-nutraceuticals-improve-multiple-parameters-hair-thinning-women/
Hair Growth Nutraceuticals Improve Multiple Parameters of Hair Thinning in Women
The use of hair growth nutraceuticals was associated with significant improvements across various measures of hair growth in women.
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