What are the consequences of autophagy loss in microglia? How do ageing/neurodegenerative diseases affect microglial autophagy? And what is the difference between autophagy and LC3-associated phagocytosis (LAP) / endocytosis (LANDO)? Please check out our new review: www.sciexplor.com/geromedicine...

Microglial autophagy and other LC3-dependent pathways in neurodegeneration

Autophagy is a conserved cellular clearance pathway that supports homeostasis by removing damaged or superfluous intracellular components. Within microglia, autophagy is emerging as a regulator of key...

sciexplor.com

🧠Sharing this Starter Pack again as the list has now reached 80 people! A great mix of Profs/PIs/Post-docs/PhDs/Technicians. Please re-post so it can reach a wider audience as I'm sure there are more of us out there ☺️🦋 go.bsky.app/S6FfsTp

An enjoyable day yesterday at the UK-Japan Neuroscience Symposium, including showing Michisuke Yuzaki (Keio University), Sharifah Anoar (UCL), and Kenji Doya (Okinawa Institute of Science and Technology) around Cambridge, followed by an engaging poster session.

Ecstatic to share that I have formally finished my PhD! Very grateful to my supervisor Prof David Rubinsztein, examiners Profs Felix Randow and Ian Ganley, and the friends and labmates (esp. @thecimr.bsky.social and @corpuscambridge.bsky.social) who have made it a very enjoyable experience!

@ukdri.ac.uk #Connectome day 1 highlight: a fantastic keynote by Prof Malcolm Macleod on improving the quality and usefulness of our science, including this example of neural correlates in a dead fish

First grant! 🎉 Extremely grateful to the Addenbrooke's Charitable Trust (ACT) for supporting this research. Also very grateful to my supervisor, David Rubinsztein, for his support (including a lot of feedback on my proposal, teaching me how to work out a budget, and letting me stay a bit longer).

Wrote my first PubPeer comment! Disappointed by a 2023 Discover Oncology publication that claims to have measured cyclic AMP by qPCR... Sleuthing reveals their primers are for the completely unrelated Cathelicidin antimicrobial peptide (CAMP). Unfortunately cAMP is the main focus of their paper.

As always, the Big Biology Day at Hills Rd Sixth Form was an absolute blast! A great morning with @alzheimersresearchuk.org and a great afternoon with @thecimr.bsky.social

Great new paper highlighting @jenniferepalmer.bsky.social 's PhD work: www.cimr.cam.ac.uk/research-adv...

The first research article from my PhD is out now in @cp-cellreports.bsky.social Read on to hear about how increased BIN1 in microglia impairs autophagy, and a physiological function for BIN1 in coordinating the closure and release of newly-formed autophagosomes www.cell.com/cell-reports...

Coordination of autophagosome closure and release by the Alzheimer’s disease-associated protein BIN1

Autophagy is a pathway that removes damaged or superfluous cellular components. Palmer et al. show that microglial upregulation of BIN1, which is associated with an increased risk of Alzheimer’s disea...

cell.com

What a fantastic day at #CambridgeFestival!! @thecimr.bsky.social contributed again to this years Cambridge Festival at the Biomedical Campus. Thanks to all amazing colleagues from @thecimr.bsky.social, @cambridgeuni.bsky.social making this event run!! More here: www.lautenschlager-lab.com/blog

Great fun today!

Alex Whitworth lab@labwhitworth.bsky.social · 2y ago

With our friends @thecimr.bsky.social

An interview for the @aotearoabrainproj.bsky.social by my previous classmate (and now Dr!!!) Lily Bentall. One of the standouts about the NZ neuroscience community to me is how connected and supportive it is - awesome mahi from the ABP! www.aotearoabrainproject.nz/news/flag-re...

FLAG Researcher Spotlight: Jenni Palmer — Aotearoa Brain Project - Kaupapa Roro o Aotearoa

Please tell us who you are, your institution and your title Kia ora, ko Jenni tōku ingoa. I'm Jenni, I'm from Whangaparāoa (North of Auckland) and I'm now based at the University of Cambridge, ...

aotearoabrainproject.nz

Great review on neuronal autophagy and synapses: www.cell.com/neuron/fullt...

Neuronal autophagy in the control of synapse function

In this review, Karpova et al. summarize and discuss the current understanding of how neurons have adopted autophagy to serve the needs of very long-living and highly polarized cells with thousands of...

cell.com

Hello! Although we are still in the other place, this will become our main social media feed. We're part of the University of Cambridge Clinical School Cell biology, molecular mechanisms of human disease

Great day at #RAREfest24 talking with people living with rare diseases, their families, other scientists, and artists (and playing with microscopes and clay of course!). My favourite things from today: these artworks about Prion disease by Emily Jolley, and the feelings of hope shared by many

🧠Re-sharing this as the list is growing. 🌲 Let me know if I've left you out - or if you think I should add someone! 🧠 go.bsky.app/S6FfsTp

To celebrate the move to Bluesky, here is our recent review on autophagy, ageing, and age-related neurodegeneration: www.cell.com/neuron/fullt...

Autophagy, aging, and age-related neurodegeneration

This review discusses the links between the autophagy pathway, aging, and age-associated neurodegeneration in Alzheimer’s, Parkinson’s, motor neuron, and Huntington’s diseases. The authors highlight t...

cell.com