@williamryder.bsky.social
Postdoctoral Research Associate in Chemical Biology for @SydneyChemistry 🇦🇺| Ex-professional chloride transporter and @GaleGroup alumni
Another of our recent most read articles, from @profphilgale.bsky.social, ‪@profmoniektromp.bsky.social‬ and colleagues: 'Anion transport in biologically relevant lipid mixtures'
Anion transport in biologically relevant lipid mixtures
A potent squaramide-based anion transporter was used to evaluate how vesicles prepared with tailored lipid compositions, which mimic organelle membranes, can impact transmembrane transport. Using…
buff.ly
Trapping anions within stacks of macrocycles pubs.acs.org/doi/10.1021/.... Collaboration between UTS, Sydney, Xiamen, Aveiro, Glasgow and Bristol. Well done and thanks to everyone involved. By forming aggregates with anions in water we can get chromate levels down to acceptable levels by filtration.
Trapping Anions within Stacks of Tetra-Urea Macrocycles
Designing molecular receptors that bind anions in water is a significant challenge, and an even greater difficulty lies in using these receptors to remove anions from water without resorting to the ha...
pubs.acs.org
Our ChemComm on anion transport on biologically relevant lipid mixtures is just out. The project was started by placement student Sarah Rooijmans from @unigroningen.bsky.social and finished by visitor Krystyna Maslowska-Jarzyna. Many congrats to all involved! pubs.rsc.org/en/content/a...
Anion transport in biologically relevant lipid mixtures
A potent squaramide-based anion transporter was used to evaluate how vesicles prepared with tailored lipid compositions, which mimic organelle membranes, can impact transmembrane transport. Using HPTS...
pubs.rsc.org
Great presentation from @williamryder.bsky.social on his PhD work at USyd on fluorescent anion transporters. Congrats on winning the best thesis prize!
Two papers from our group both led by PhD students out in Chem this month www.cell.com/chem/abstrac... and www.cell.com/chem/abstrac.... Many congrats to Billy Ryder and Alex Gilchrist and the rest of the team. Many thanks to Jen Hiscock too for writing the Preview. www.cell.com/chem/abstrac...
Subcellular targeted anion transporters
Ryder et al. report the first subcellular targeted anion transporters that accumulate in specific membrane-bound organelles to bias their natural propensity to depolarize lysosomes. Confocal microscopy revealed the ability of the naphthalimide-based transporters to localize within their intended organelles. Analogs that contained endoplasmic reticulum (ER) and lysosomal targeting motifs showed an enhanced H+/Cl− transport ability and cytotoxicity compared with non-targeted analogs. Moreover, lysosomal accumulation improved cancer cell selectivity, while ER and mitochondrial localization enhanced apoptosis in cancerous cells.
cell.com
