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UMR 3523

@chem4life.bsky.social

Welcome on UMR 3523 Bluesky profile / Bienvenus sur le profile Bluesky de l'UMR 3523 #CNRSChimie

3 Posts20 Follower21 Folgt
@hollensteinlab.bsky.social · 2w ago

Very happy to share a preprint on our contribution to identifying a polymerase capable of accepting heavily modified nucleotides. Great collaboration with Marc Delarue and John Chaput. Congrats to Maria! @pasteur.fr @ipdbsc.bsky.social @chem4life.bsky.social www.biorxiv.org/content/10.6...

Polymerase Evolution Enables Access to Glycosylated Xeno-Nucleic Acids with Expanded Chemical Functionality

Chemical modifications expand the functional repertoire of nucleic acids, but the extent to which complex glycans can be integrated into genetic polymers remains largely unexplored. Glycosylated nucle...

biorxiv.org

@hollensteinlab.bsky.social · 2mo ago

Thrilled to share our recent pre-print where we studied the stereochemical outcome of phosphorothioate bond formation during ligation. Congratulations to Erwann and Nazarii. Great collaboration with Roche. @pasteur.fr @chem4life.bsky.social @cnrs.fr @ipdbsc.bsky.social chemrxiv.org/doi/full/10....

Chemoenzymatic Access to Stereodefined Phosphorothioate Oligonucleotides by Stereoselective DNA Ligation | ChemRxiv

Recent studies have demonstrated that stereopure oligonucleotide phosphorothioates (PS), with defined configuration, provide significant advantages over stereorandom mixtures in therapeutic oligonucle...

chemrxiv.org

@hollensteinlab.bsky.social · 5mo ago

Very happy to share our recent article on the synthesis of Ru-complex modified DNA by SPAAC together with @gassergroup.bsky.social Congrats to all authors! @ipdbsc.bsky.social @chem4life.bsky.social @pierrenicolasbizat.bsky.social chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

Incorporation of Ruthenium Polypyridyl Complexes Into DNA Oligonucleotides by Copper‐Free Click Chemistry

Alternative methods for the preparation of naïve libraries for SELEX experiments are in dire need, particularly when hydrophobic, bulky, and complex modification patterns are considered. Here, we exp...

chemistry-europe.onlinelibrary.wiley.com

@hollensteinlab.bsky.social · 2y ago

Very happy to share our new preprint on the selection of COT-modified aptamers. Great work by undergraduate student Charlotte. Congrats to all! chemrxiv.org/engage/chemr... Stay tuned for the published version. @pasteur.fr @chem4life.bsky.social @hollensteinlab.bsky.social @chemrxiv.bsky.social

Probing three-dimensional cyclooctatetraene as nucleobase modification in aptamer selection

Decoration of aptamers with chemical modifications at the level of nucleobases grants access to alternative binding modes which often result in improved binding properties. Most functional groups invo...

chemrxiv.org

@hollensteinlab.bsky.social · last yr.

Thrilled to share our article published @chemsocrev.bsky.social on sugar modified nucleic acids. Congrats to Debashis! Great collaboration with Laurence Mulard. @pasteur.fr @ipdbsc.bsky.social @chem4life.bsky.social @cnrs.fr pubs.rsc.org/en/content/a...

Natural, modified and conjugated carbohydrates in nucleic acids

Storage of genetic information in DNA occurs through a unique ordering of canonical base pairs. However, this would not be possible in the absence of the sugar–phosphate backbone which is essential fo...

pubs.rsc.org

UMR 3523 @chem4life.bsky.social · last yr.

Dear all, The Department of Structural Biology and Chemistry is pleased to invite you to the Half-Day of Drug Discovery this Tuesday, March 4th, at 1:30 PM in the Auditorium François Jacob. Program details : research.pasteur.fr/fr/event/hal... #InstitutPasteur #DBSC #Chem4Life #CNRS #DrugDiscovery

HALF-DAY DRUG DISCOVERY, Department of Structural Biology and Chemistry - Research

Institut Pasteur, ParisAuditorium François JacobMarch 4, 2025 PROGRAM 13:30 OPENING 13:40 Suzanne PEYROTTES (IBMM, Montpellier) “Discovery of an AcycloNucleoside Phosphonate (ANP) as potent inhibitor ...

research.pasteur.fr

Pierre Nicolas BIZAT@pierrenicolasbizat.bsky.social · 2y ago

I am very happy to share my first publication. ✨ Our review with @hollensteinlab.bsky.social and Nazarii Sabat on biocatalytic approaches for the synthesis of oligonucleotides. 🧬 @pasteur.fr @chem4life.bsky.social chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

Recent advances in biocatalytic and chemoenzymatic synthesis of oligonucleotides

Access to synthetic oligonucleotides is crucial for applications in diagnostics, therapeutics, synthetic biology, and nanotechnology. Traditional solid phase synthesis is limited by sequence length a...

chemistry-europe.onlinelibrary.wiley.com

Structural Biology and Chemistry Dpt - Institut Pasteur@ipdbsc.bsky.social · last yr.

The Structural Biology and Chemistry Department at Institut Pasteur is seeking a junior or mid-career researcher to lead a new group in Medicinal Chemistry, Chemical Biology or Structural Biology research.pasteur.fr/en/call/call...

Call for applications 2025 - Creation of new research groups at the Institut Pasteur - Research

The Institut Pasteur launches an international call to recruit new junior research group leaders in the application of cutting-edge transdisciplinary approaches to the exploration of host-microbe, tis...

research.pasteur.fr