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Renhao Luo

@renhaol.bsky.social

PhD student @scripps.edu (He/Him)

1 Posts35 Follower88 Folgt
Ardem Patapoutian@ardemp.bskyverified.social · 8mo ago

New paper from the lab led by @ericmulhall.bsky.social addresses how PIEZO1 and PIEZO2 are tuned to different types mechanical forces. From nanometer-scale super-resolution microscopy to in vivo experiments, links single-molecule observations to physiological function. www.nature.com/articles/s41...

The molecular basis of force selectivity by PIEZO2

Nature - PIEZO2 is intrinsically more rigid than PIEZO1, and disparate mechanical stimuli paradoxically evoke opposite conformational and gating responses in each channel.

nature.com

Ardem Patapoutian@ardemp.bskyverified.social · 11mo ago

And here is the story after peer review. This work highlights our current approach, which is to use Piezo channels to uncover new areas of biology that are shaped by mechanical forces: www.science.org/doi/10.1126/...

PIEZO channels link mechanical forces to uterine contractions in parturition

Mechanical forces are extensively involved in pregnancy and parturition, but their precise roles and mechanisms remain poorly understood. We identified mechanically activated ion channels PIEZO1 and P...

science.org

Ardem Patapoutian@ardemp.bskyverified.social · last yr.

New preprint alert! The uterus expands ~500-fold in pregnancy, yet we know little about how pressures are sensed. Led by @yunxiao-dr.bsky.social, we show PIEZOs are required for contractions and birth in mice, with dual roles of PIEZO1 in muscle and PIEZO2 in neurons www.biorxiv.org/content/10.1...

Ardem Patapoutian@ardemp.bskyverified.social · last yr.

New preprint alert! The uterus expands ~500-fold in pregnancy, yet we know little about how pressures are sensed. Led by @yunxiao-dr.bsky.social, we show PIEZOs are required for contractions and birth in mice, with dual roles of PIEZO1 in muscle and PIEZO2 in neurons www.biorxiv.org/content/10.1...

PIEZO channels link mechanical forces to uterine contractions in parturition

Mechanical forces are extensively involved in pregnancy and parturition, but their precise roles and mechanisms remain poorly understood. Here, we identify mechanically activated ion channels PIEZO1 a...

biorxiv.org

Nature Neuroscience@natneuro.nature.com · last yr.

Protective exercise responses in the dentate gyrus of Alzheimer’s disease mouse model revealed with single-nucleus RNA-sequencing www.nature.com/articles/s41...

Protective exercise responses in the dentate gyrus of Alzheimer’s disease mouse model revealed with single-nucleus RNA-sequencing - Nature Neuroscience

Dissecting the adaptive exercise response of the neurogenic stem-cell niche in the dentate gyrus by single-nucleus RNA sequencing reveals the molecular mediators that underlie exercise’s protective ef...

nature.com