Very excited to share our new manuscript – published today! Why are PIEZO1 and PIEZO2 are tuned to transduce different types of mechanical force? I was lucky to work with some extraordinary colleagues to begin to figure out why. www.nature.com/articles/s41... An overview of the results below ⬇️ ⬇️

The molecular basis of force selectivity by PIEZO2 - Nature

PIEZO2 is intrinsically more rigid than PIEZO1, and disparate mechanical stimuli paradoxically evoke opposite conformational and gating responses in each channel.

nature.com

My message to Trump’s NIH Director? No one in America wants us to do LESS cancer research. No one is asking Trump to make it harder to cure Alzheimer's disease. Yet Trump is cutting all of this NOW and demanding an $18 BILLION cut to NIH next year. Not on my watch.

Attending ASCB|EMBO? Join us for a Special Interest Subgroup on Sensory Receptors, featuring @ericmulhall.bsky.social, @rachellegaudet.bsky.social, Eric Gouaux, Maude Baldwin, Juan Du and Corey Allard, co-organized with Josefina del Marmol @delmarmollab.bsky.social #CellBio2024