Tessera

Eric Mulhall

@ericmulhall.bsky.social

Postdoc in Patapoutian Lab @ Scripps Sensory Neuroscience / Single-Molecule Biophysics / Force-Gated Ion Channels / Vegetable Enthusiast

10 Posts163 Follower 187 Folgt

Neuron @cp-neuron.bsky.social · 2mo ago

An inherited hypomorphic variant in PIEZO2 reveals structural features of mechanotransduction

Nickolls et al. identify a clinical variant in PIEZO2 that impairs touch sensation and body awareness. By showing how this variant prevents PIEZO channels from opening and deforming under pressure, the study adds to our understanding of how specific PIEZO protein domains contribute to force-induced conformational changes.

dlvr.it

Eric Mulhall @ericmulhall.bsky.social · 7mo ago

Very excited to share our new manuscript – published today! Why are PIEZO1 and PIEZO2 are tuned to transduce different types of mechanical force? I was lucky to work with some extraordinary colleagues to begin to figure out why. www.nature.com/articles/s41... An overview of the results below ⬇️ ⬇️

The molecular basis of force selectivity by PIEZO2 - Nature

PIEZO2 is intrinsically more rigid than PIEZO1, and disparate mechanical stimuli paradoxically evoke opposite conformational and gating responses in each channel.

nature.com

Senator Patty Murray @murray.senate.gov · last yr.

My message to Trump’s NIH Director? No one in America wants us to do LESS cancer research. No one is asking Trump to make it harder to cure Alzheimer's disease. Yet Trump is cutting all of this NOW and demanding an $18 BILLION cut to NIH next year. Not on my watch.

Paul Garrity @paulgarrity.bsky.social · 2y ago

Attending ASCB|EMBO? Join us for a Special Interest Subgroup on Sensory Receptors, featuring @ericmulhall.bsky.social, @rachellegaudet.bsky.social, Eric Gouaux, Maude Baldwin, Juan Du and Corey Allard, co-organized with Josefina del Marmol @delmarmollab.bsky.social #CellBio2024