@almudenachaves.bsky.social

Also honored to see our work highlighted in Nature! Huge thanks to Navdeep S. Chandel and Ram P. Chakrabarty for the thoughtful and insightful News & Views piece, describing the unexpected role of Ogdh and alpha-ketoglutarate in intestinal healing. www.nature.com/articles/d41...

Mitochondrial molecule has unexpected role in tissue healing

A key component of the TCA cycle, a series of reactions that occurs in energy-generating organelles called mitochondria, can dictate the fate of intestinal stem cells.

nature.com

Thrilled to share that the last paper of my postdoc is now out in @nature.com ! We show how metabolic rewiring through OGDH drives tissue regeneration and stem cell fate. A wild and rewarding ride—huge thanks to Scott Millman and the Scott Lowe lab! www.nature.com/articles/s41...

Metabolic adaptations direct cell fate during tissue regeneration - Nature

Metabolic enzymes of the tricarboxylic acid cycle, such as 2-oxoglutarate dehydrogenase, are differentially expressed in absorptive and secretory lineages, guiding cell fate establishment and offering...

nature.com