Eliminating the confounding effects of human pluripotent #stemcell co-culture with MEFs: @grazianomartello.bsky.social @leeboratory.bsky.social @jzylicz.bsky.social and collaborators describe a serum coating approach for feeder-free culture of naïve hPSCs link.springer.com/article/10.1...

Serum coating enables feeder-free culture of naive human pluripotent stem cells preserving developmental potential - The EMBO Journal

Naive human pluripotent stem cells (hPSCs) represent a pre-implantation epiblast state able to efficiently differentiate into embryonic and extraembryonic pre-implantation lineages and to self-organis...

link.springer.com

🎆 Happy new year and our first 2026 issue is out! Cover: #epiblast development 👉Perspective: biological clocks 👉Review: #mitosis #CellDeath #inflammation 🔬 #chromatin #cancer #Bcells #Tcells #autophagy #organoids #mechanobiology #TranscriptionFactors #Xist & more! www.nature.com/ncb/volumes/...

🚨 New paper out! A human epiblast model reveals how dynamic TGF‑β signalling controls epithelial identity in early mammalian development Here is the full paper: rdcu.be/eSWEs 🧵 A twittorial: THREAD

A human epiblast model reveals dynamic TGFβ-mediated control of epithelial identity during mammalian epiblast development

Nature Cell Biology - The authors optimize an in vitro human epiblast model, which they utilize to show that early TGFβ family inhibition prevents epithelial identity, whereas it is...

rdcu.be

With pleasure we share our preprint reporting robust and cost-effective expansion of naive human Pluripotent Stem Cells without feeder cells. A fantastic collaborative effort with @leeboratory.bsky.social @jzylicz.bsky.social @pasquelab.bsky.social and Nicolas Rivron. tinyurl.com/5n6z9rt9