A biophysically principled sequence model IceQream characterises complex Transcription Factor-DNA interactions from chromosome accessibility analysis. @Akhiad.bsky.social #BiotechNatureComms www.nature.com/articles/s41...

IceQream: Quantitative chromosome accessibility analysis using physical TF models - Nature Communications

Cis regulatory elements endow genomes with sequence-encoded logic to drive cellular differentiation. Here, the authors introduce a biophysically principled sequence model that characterises complex TF...

nature.com

Do we need LLMs to predict epigenomes from DNA—or is biophysics enough? 🧬 IceQream (IQ) is a biophysics-based framework that predicts epigenomes with SOTA-level accuracy—and is fully explainable. @NatureComms: www.nature.com/articles/s41... Thread 🧵👇 1/