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Maxwell Madden

@maxwellmadden.bsky.social

14 Posts78 Follower 106 Folgt

Maxwell Madden @maxwellmadden.bsky.social · 3w ago

Excited to share my preprinted manuscript "A Low-Cost, Modular Hardware and Software Platform for Head-Fixed Mouse Decision-Making Tasks". www.biorxiv.org/content/10.6...

A Low-Cost, Modular Hardware and Software Platform for Head-Fixed Mouse Decision-Making Tasks

Head-fixed behavior in rodents is a foundational technique in systems neuroscience which enables use of sophisticated imaging techniques in combination with animal behavior. However, accessibility of ...

biorxiv.org

Mark Histed @markhisted.org · 2mo ago

I co-sign this great summary from @dereklowe.bsky.social . The goal is to destroy academic science, and these are the reasons. And all the “gold standard” and “needs reform” and “not high risk” stuff is transparent bullshit to hide the ball on what they are doing.

=
Science
science. But let me make something clear right up front. When I talk to people about this subject (and that includes some journalists as well) and say what I'm about to at the end of this paragaph I am sometimes met with disbelief. But I mean what I say and I am trying my best to say what I mean: The Trump administration hates academic science funding, full stop. They hate where that money goes, and they hate who it goes to. They want to keep all that money for themselves, to hand out to favored cronies who can help them get elected and to steer yet more money and more power back into their hands.
That's it. That's the story. They are naturally not putting it in those words, but instead talking about "gold standard science" and the
"reproducibility crisis" and funding "bold inquiry" for "transformational
breakthroughs". This is all bullshit, and it's important to realize that. Shameless hand-waving bullshit, delivered in a how-dare-vou-

Derek Lowe@dereklowe.bsky.social · 2mo ago

Thoughts on the various Trump administration proposals to revamp US science funding - and what they all have in common:

Kristen Montgomery @kristenmontgomery.bsky.social · 9mo ago

A favorite recent image of some busy microglia, lovingly named the Rat King (yellow CD68, pink Iba1, blue DAPI) for my first #FluorescenceFriday

Armando Rubio Ramos @bioarm.bsky.social · 10mo ago

This is a glimpse of the cytoskeletal structures we found doing U-ExM in more than 200 species, now in Cell🤩: shorturl.at/6oHvi Amazing collaboration between @centriolelab.bsky.social , @dudinlab.bsky.social and @gautamdey.bsky.social labs. I believe last one is a 🕷️ #FluorescenceFriday #Microscopy

Barack Obama @barackobama.bsky.social · 10mo ago

Congratulations to all the Democratic candidates who won tonight. It’s a reminder that when we come together around strong, forward-looking leaders who care about the issues that matter, we can win. We’ve still got plenty of work to do, but the future looks a little bit brighter.

Tanner Anderson, PhD @tanner-anderson.bsky.social · 11mo ago

Check out my most recent paper published in #eNeuro A pre and post spiking protocol depresses claustrocortical EPSPs, unless you perform the same protocol in the presence of DOI, then the polarity reverses into potentiation! We also see some DOI effects on spike kinetics.

SfN Journals@sfnjournals.bsky.social · 11mo ago

New in #eNeuro from Anderson et al: Psychedelics strengthen synapses on claustrum neurons that project to the anterior cingulate cortex in male rats. vist.ly/4bwdb

Jun Nagai @junnagai.bsky.social · 11mo ago

Just out in Nature! “The astrocytic ensemble acts as a multiday trace to stabilize memory.” We identified astrocytic ensembles that link experiences across days to stabilize memory nature.com/articles/s41.... New astrocyte tools are openly available at Addgene: addgene.org/Jun_Nagai/. 1/8

Maxwell Madden @maxwellmadden.bsky.social · 11mo ago

Currently building a patch ephys rig and agonizing over camera selection. Do any patchers have any advice on what specifications I should be prioritizing? Also, has anyone used the Thorlabs Kiralux sCMOS cameras? 🧪

Justin Hendrix @justinhendrix.bsky.social · last yr.

"While ChatGPT use has been linked to suicides and mental-health hospitalizations among heavy users, this appears to be the first documented murder involving a troubled person who had been engaging extensively with an AI chatbot."

Olivia Guest · Ολίβια Γκεστ @olivia.science · last yr.

Finally! 🤩 Our position piece: Against the Uncritical Adoption of 'AI' Technologies in Academia: doi.org/10.5281/zeno... We unpick the tech industry’s marketing, hype, & harm; and we argue for safeguarding higher education, critical thinking, expertise, academic freedom, & scientific integrity. 1/n

Abstract: Under the banner of progress, products have been uncritically adopted or
even imposed on users — in past centuries with tobacco and combustion engines, and in
the 21st with social media. For these collective blunders, we now regret our involvement or
apathy as scientists, and society struggles to put the genie back in the bottle. Currently, we
are similarly entangled with artificial intelligence (AI) technology. For example, software updates are rolled out seamlessly and non-consensually, Microsoft Office is bundled with chatbots, and we, our students, and our employers have had no say, as it is not
considered a valid position to reject AI technologies in our teaching and research. This
is why in June 2025, we co-authored an Open Letter calling on our employers to reverse
and rethink their stance on uncritically adopting AI technologies. In this position piece,
we expound on why universities must take their role seriously toa) counter the technology
industry’s marketing, hype, and harm; and to b) safeguard higher education, critical
thinking, expertise, academic freedom, and scientific integrity. We include pointers to
relevant work to further inform our colleagues.

Figure 1. A cartoon set theoretic view on various terms (see Table 1) used when discussing the superset AI
(black outline, hatched background): LLMs are in orange; ANNs are in magenta; generative models are
in blue; and finally, chatbots are in green. Where these intersect, the colours reflect that, e.g. generative adversarial network (GAN) and Boltzmann machine (BM) models are in the purple subset because they are
both generative and ANNs. In the case of proprietary closed source models, e.g. OpenAI’s ChatGPT and
Apple’s Siri, we cannot verify their implementation and so academics can only make educated guesses (cf.
Dingemanse 2025). Undefined terms used above: BERT (Devlin et al. 2019); AlexNet (Krizhevsky et al.
2017); A.L.I.C.E. (Wallace 2009); ELIZA (Weizenbaum 1966); Jabberwacky (Twist 2003); linear discriminant analysis (LDA); quadratic discriminant analysis (QDA).

Table 1. Below some of the typical terminological disarray is untangled. Importantly, none of these terms
are orthogonal nor do they exclusively pick out the types of products we may wish to critique or proscribe.

Protecting the Ecosystem of Human Knowledge: Five Principles

Wesley R. Evans @scred62.bsky.social · last yr.

Here's a look at a field of striatal astrocytes expressing GCaMP6f-cyto from the Huda Lab for #FluorescenceFriday !

Maxwell Madden @maxwellmadden.bsky.social · last yr.

Excited my PhD work in @brianmathur.bsky.social’s lab is now published and available!

Bertoglio lab (FMC/UFSC)@bertogliolab.bsky.social · last yr.

Serotonin and psilocybin activate 5-HT1B receptors to suppress cortical signaling through the claustrum doi.org/10.1038/s414...