NEW STUDY! 📣 A large global study found men are more likely to be exposed to TB than women. The reason? Likely social behaviours: • More time in crowded indoor spaces • Delays in seeking care READ MORE ⤵️ 🔗 www.thelancet.com/journals/lan... @petermacp.bsky.social @hannahrickman.bsky.social

🚨”Amita Gupta has spent more than a decade planning and running a US$70-million trial to study a new #tuberculosis drug, enrolling nearly 6,000 participants across 13 countries. It might all have been for nothing. Gupta’s trial has been ensnared by… [new] NIH policy… that bans ‘foreign subawards’”⤵️

Nature@nature.com · last yr.

NIH funding will abruptly cease for dozens, if not hundreds, of ongoing overseas trials of drugs and treatments. Its policy change puts thousands of trial participants in limbo. https://go.nature.com/3Z8xNM1

#Tuberculosis Journal Club **TODAY** 4pm UK time. @jaseddon.bsky.social & Dr Amedine Duret taking us through the drivers of adolescent TB 👫 pmc.ncbi.nlm.nih.gov/articles/PMC... by Silvia Chiang, @petedodd24.bsky.social &al Hope to see you there! eepurl.com/hO4D79 to join mailing list ✉️ #tbsky

Factors driving adolescent tuberculosis incidence by age and sex in 30 high-tuberculosis burden countries: a mathematical modelling study

During adolescence, tuberculosis incidence rises, with a greater increase in males compared with females. Tuberculosis notifications and estimates infrequently disaggregate adolescent age groups. More...

pmc.ncbi.nlm.nih.gov

Each day of funding cuts means 11,000 people with TB may not complete their treatment. Stopping TB programs isn't just bad policy – it’s a public health catastrophe. Countless lives are at stake! #FundTBNow #FundingCutsCostLives

Brilliant presentation by Verena Faehling & chairing by Liz Corbett - thanks so much all who joined for a great discussion 👏 eepurl.com/hO4D79 to join mailing list for future sessions.

TB Journal Club@tbjournalclub.bsky.social · last yr.

Kicking off #TB #JournalClub 2025 with great discussion of shorturl.at/AGD8l Duong &al 2024 meta-analysis of VQUIN & TB-CHAMP RCTs. In our closing poll, 54% of audience members would take levo TPT if their household contact had quinolone-sensitive #DRTB - the rest chose another regimen/no TPT #tbsky

First TB Journal Club of 2025 meets *this Thursday* 20th at 4pm UK time 🕓 Liz Corbett & Verena Faehling @lshtm.bsky.social will be discussing shorturl.at/AGD8l Duong &al 2024 meta-analysis of VQUIN & TB-CHAMP RCTs of levofloxacin for #MDRTB contacts. Hope to see you there! #tbsky #tuberculosis

A Meta-Analysis of Levofloxacin for Contacts of Multidrug-Resistant Tuberculosis

Data from randomized trials evaluating the effectiveness of tuberculosis (TB) preventive treatment for contacts of multidrug-resistant (MDR)-TB are lacking. Two recently published randomized trials...

shorturl.at

Early data from @publichealthscot.bsky.social show that RSV vaccination (Pfizer ABRYSVO) in older adults aged 75-79 years was associated with 62% ⬇️ (95%CI 35-80%) in #RSV hospitalisation. 🦠🏥💉🏴󠁧󠁢󠁳󠁣󠁴󠁿👏 Vaccination commenced mid August 2024 & uptake was 68.6% by end of Nov 2024.

Today is International Day of Women & Girls in Science. Marie Curie, the first woman to win a Nobel Prize. Her contributions have left an indelible mark on the world of science & health & continue to inspire generations of scientists & innovators. 🔬 #WomenInScience #WomenInSTEM

A paper in Nature Medicine reports that participation in Brazil’s Bolsa Familia Program, one of the largest conditional cash transfer programs in the world, was associated with large reductions in tuberculosis incidence and mortality among various groups. #Medsky 🧪

Effects of conditional cash transfers on tuberculosis incidence and mortality according to race, ethnicity and socioeconomic factors in the 100 Million Brazilian Cohort - Nature Medicine

Participation in Brazil’s Bolsa Familia Program, one of the largest conditional cash transfer programs in the world, was associated with large reductions in tuberculosis incidence and mortality among Indigenous people, individuals of Black and Pardo ethnicity and those living in extreme poverty.

go.nature.com

Compelling analysis suggesting that M:F difference in TB rates driven by differences in rates of Mtb infection. Consistent with old (2000) analysis of genotypic clustering (PMID: 10654640). But why do zoonotic TB series often have flipped ratios? doi: 10.1093/infdis/jiae124

Hannah Rickman@hannahrickman.bsky.social · 2y ago

New preprint (with all pre-print caveats!) tinyurl.com/589ffhu4 on Mtb infection risk by sex & age. Men are at higher risk of #tuberculosis v women- but unclear how much driven by higher infection vs progression to disease. We meta-analysed Mtb immunoreactivity surveys to find out more🧵 #tbsky

New pre-print led by @hannahrickman.bsky.social tinyurl.com/589ffhu4 We meta-analysed ~half a million participants from #TB infection surveys. From adolescence, men have much higher risk of acquiring new TB infection than women. Probably due to social exposure and assortative mixing. #IDsky 🧪🦠🛟

Hannah Rickman@hannahrickman.bsky.social · 2y ago

We found that from adolescence onwards, rates of Mtb conversion increased, and men were at higher risk of acquiring new Mtb infection than women. Mtb conversion was highest at age ~30, and was up to 1.5-times higher in men than in women. This was consistent across settings (regions, rural/urban). 🧵

New preprint (with all pre-print caveats!) tinyurl.com/589ffhu4 on Mtb infection risk by sex & age. Men are at higher risk of #tuberculosis v women- but unclear how much driven by higher infection vs progression to disease. We meta-analysed Mtb immunoreactivity surveys to find out more🧵 #tbsky

We had high hopes for an #IGRA platform overcoming barriers to use in high #tuberculosis burden settings. Unfortunately it didn't perform as expected, esp in young children #idsky #tbsky shorturl.at/dAcPD Great to work with a fantastic team at Malawi Liverpool Wellcome prog & @lshtm.bsky.social

We urgently need a better, easier-to-use test for #TB infection. We evaluated the QIAreach test among 1049 children and adults in 🇲🇼 Unfortunately, performance was poor & can’t be recommended for use #TBsky #IDSky @hannahrickman.bsky.social doi.org/10.1128/jcm....

REMINDER - final TBJC of 2024 is tomorrow at 4pm UK time. Look forward to seeing you there! #tuberculosis #journalclub

TB Journal Club@tbjournalclub.bsky.social · 2y ago

❗Final #TBJC of 2024 🕓Thurs November 28, 4pm UK 🏛️Hosts: SGUL. Chair: Sean Wasserman. Presenter: Sharenja Ratnakumar. 💊 shorturl.at/jcijg long-term efficacy & safety from STREAM2 trial of shorter regimens for #DRTB ✉️ eepurl.com/hO4D79 to join mailing list for monthly #tuberculosis journal clubs!

Huge huge congratulations to this amazing scientist & excellent human @rachaelburke.bsky.social 👏

Peter MacPherson@petermacp.bsky.social · 2y ago

🎉🎉Huge congrats to Dr Rachael Burke @rachaelburke.bsky.social on winning the Stephen Lawn Memorial Prize for #tuberculosis research🎉🎉🎉 Rachael leads amazing work improving diagnosis of TB in people with #HIV & in understanding the impact of community TB screening *Very proud PhD supervisor! #TBsky

Read this amazing preprint today: ~2% (156M) of the world recently infected with #tb. Between 4.9%~7.7% have viable infection. But emphasises we need +++ data on Mtb infection @aschwalbc.bsky.social @kchorton.bsky.social @petedodd24.bsky.social @reinhouben.bsky.social @hannahrickman.bsky.social

Final TB Journal Club of 2024! Hope to see you there.

TB Journal Club@tbjournalclub.bsky.social · 2y ago

❗Final #TBJC of 2024 🕓Thurs November 28, 4pm UK 🏛️Hosts: SGUL. Chair: Sean Wasserman. Presenter: Sharenja Ratnakumar. 💊 shorturl.at/jcijg long-term efficacy & safety from STREAM2 trial of shorter regimens for #DRTB ✉️ eepurl.com/hO4D79 to join mailing list for monthly #tuberculosis journal clubs!

We host monthly online international journal clubs on the latest #tuberculosis literature. We welcome researchers, clinicians, and anyone else interested in #TB - eepurl.com/hO4D79 to join the mailing list & hear about future meetings.

I made one for 'types of paper in epidemiology and public health' #EpiSky

Maarten van Smeden@maartenvsmeden.bsky.social · 2y ago

I made one for stats papers

1/📢 In our new PREPRINT - tinyurl.com/yc6kbay9 - we estimate that 156 million people globally carry a recent, viable M. tuberculosis (Mtb) infection and are at high risk of progressing to TB disease.

Here is a really nice report from BBC Scotland into our research. www.bbc.co.uk/news/article...

How cigarettes, chickens and chocolates hleped to stopped a TB epidemic

In 1957, Glasgow had the highest death rate from TB in Europe so health officials offered free prize draws for those who got X-rayed.

bbc.co.uk

Peter MacPherson@petermacp.bsky.social · 2y ago

DYK in 1957, Glasgow, Scotland ran the largest ever screening campaign against #tuberculosis? 715,000 people (76% of entire adult population) were X-rayed over just 5 weeks! In a new study, we looked at the long-term impact of this campaign. journals.plos.org/plosmedicine... #episky #idsky 🧪🛟

DYK in 1957, Glasgow, Scotland ran the largest ever screening campaign against #tuberculosis? 715,000 people (76% of entire adult population) were X-rayed over just 5 weeks! In a new study, we looked at the long-term impact of this campaign. journals.plos.org/plosmedicine... #episky #idsky 🧪🛟