Neutropenic Enterocolitis: An Uncommon, but Fearsome Complication of Leukemia

Neutropenic enterocolitis (NEC) is a life-threatening condition occurring in severely neutropenic patients, following intensive chemotherapy for leukemia. Its pathogenesis is not entirely understood a...

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Bacteremia and endocarditis due to methicillin-resistant Staphylococcus aureus: the potential role of daptomycin

Staphylococcus aureus bacteremia is a common disease with a high risk of mortality and complications. An increasing proportion of cases are methicillin-resistant S.aureus (MRSA), and methicillin-resis...

pmc.ncbi.nlm.nih.gov

A systems perspective on ribavirin-induced hemolytic anemia: From network toxicology to atomic-level simulations

The molecular mechanisms underlying ribavirin (RBV)-induced hemolytic anemia remain incompletely understood. Current research predominantly addresses …

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Prophylactic azithromycin for chronic lung allograft dysfunction following lung transplantation: a systematic review and meta-analysis

Azithromycin (AZI) has proven effective in improving pulmonary function and survival in certain patients with established chronic lung allograft dysfunction (CLAD) following lung transplantation (LTx)...

pmc.ncbi.nlm.nih.gov

Posaconazole Serum Drug Levels Associated With Pseudohyperaldosteronism

Posaconazole-induced pseudohyperaldosteronism is associated with higher posaconazole serum concentrations, which are correlated with increased blood pressu

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Compassionate use of a novel β-lactam enhancer-based investigational antibiotic cefepime/zidebactam (WCK 5222) for the treatment of extensively-drug-resistant NDM-expressing Pseudomonas aeruginosa inf...

Infections in critically-ill patients caused by extensively-drug-resistant (XDR)-Pseudomonas aeruginosa are challenging to manage due to paucity of effective treatment options. Cefepime/zidebactam, wh...

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Neuroinvasive Bacillus cereus Infection in Immunocompromised Hosts: Epidemiologic Investigation of 5 Patients With Acute Myeloid Leukemia

We describe 5 health care–associated neuroinvasive Bacillus cereus infections. No point source was identified, and isolates were unrelated. Enhancing envir

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<i>Rhodotorula mucilaginosa</i> Fungemia, a Rare Opportunistic Infection without Central Venous Catheter Implantation, Successfully Treated by Liposomal Amphotericin B

Background. Fungemia due to Rhodotorula mucilaginosa is rare and highly resistance to antifungal therapy. Since most cases of R. mucilaginosa fungemia are attributed to medical devices, limited infor...

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Short- and long-term effects of oral vancomycin on the human intestinal microbiota

Background. Oral vancomycin remains the mainstay of therapy for severe infections produced by Clostridium difficile, the most prevalent cause of healthcare

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Mammalian meat allergy emerges after tick bite: the alpha-gal syndrome

Alpha-gal syndrome (AGS) is a hypersensitivity reaction to mammalian meat that develops after tick bite exposure. AGS was first described in 2009 and testing for the allergy has become available in th...

pmc.ncbi.nlm.nih.gov

Plasma Fluoride Level as a Predictor of Voriconazole-Induced Periostitis in Patients With Skeletal Pain

Periostitis has been an infrequently observed side effect of long-term, high-dose voriconazole therapy. We report a retrospective study correlating elevate

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Effect of renal function on the risk of thrombocytopaenia in patients receiving linezolid therapy: A systematic review and meta‐analysis

The association of renal function and linezolid‐induced thrombocytopaenia (LIT) remains controversial. We performed a meta‐analysis to determine whether impaired renal function is associated with an i...

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Sage Journals: Discover world-class research

Subscription and open access journals from Sage, the world's leading independent academic publisher.

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Sepsis-associated hyperlactatemia - Critical Care

There is overwhelming evidence that sepsis and septic shock are associated with hyperlactatemia (sepsis-associated hyperlactatemia (SAHL)). SAHL is a strong independent predictor of mortality and its ...

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A Diagnostic Dilemma: Daptomycin-Induced Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Syndrome and Eosinophilic Pneumonia With Concurrent COVID-19

Adverse drug reactions are critical considerations in managing complex medical conditions. Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a rare but potentially life-threate...

pmc.ncbi.nlm.nih.gov

Albumin: Biochemical properties and therapeutic potential<link href='#fn1'></link>

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The Association of <i>Streptococcus gallolyticus</i> Subspecies <i>pasteurianus</i> Bacteremia with the Detection of Premalignant and Malignant Colonic Lesions

Streptococcus gallolyticus subspecies (subsp.) gallolyticus (formerly bovis biotype I) bacteremia has been associated with colonic adenocarcinoma. The bovis species underwent reclassification in 2003....

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Antimicrobial Treatment Strategies for Stenotrophomonas maltophilia: A Focus on Novel Therapies

Stenotrophomonas maltophilia is an urgent global threat due to its increasing incidence and intrinsic antibiotic resistance. Antibiotic development has focused on carbapenem-resistant Enterobacteriace...

pmc.ncbi.nlm.nih.gov

Pneumocystis jirovecii Pneumonia in HIV-Negative, Non-transplant Patients: Epidemiology, Clinical Manifestations, Diagnosis, Treatment, and Prevention - Current Fungal Infection Reports

Purpose of Review Pneumocystis jirovecii pneumonia (PJP) is an opportunistic fungal infection that is increasingly seen in HIV-negative patients with immune compromise due to other etiologies. We lack...

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Predicting Antibiotic Resistance in Urinary Tract Infection Patients with Prior Urine Cultures | Antimicrobial Agents and Chemotherapy

ABSTRACT To improve antibiotic prescribing, we sought to establish the probability of a resistant organism in urine culture given a previous resistant culture in a setting endemic for multidrug-resist...

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High incidence of neutropenia in patients with prolonged ceftaroline exposure

We sought to determine the rate of incident neutropenia and identify potential clinical factors associated with incident neutropenia among patients treated with long courses of ceftaroline. We retrosp...

pmc.ncbi.nlm.nih.gov

Valproate Interaction With Carbapenems: Review and Recommendations

Introduction: Valproic acid is a commonly used antiepileptic drug. Combining valproate derivatives with carbapenem antibiotics is associated with a potential drug interaction that decreases serum conc...

pmc.ncbi.nlm.nih.gov

Outcomes of Daptomycin Plus Ceftaroline Versus Alternative Therapy for Persistent Methicillin-resistant Staphylococcus aureus (MRSA) Bacteraemia

This study aimed to evaluate both efficacy and safety of combination therapy with daptomycin plus ceftaroline (DAP/CPT) versus alternative therapy in …

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Antibiotics in Necrotizing Soft Tissue Infections

Necrotizing soft tissue infections (NSTIs) are rare life-threatening bacterial infections characterized by an extensive necrosis of skin and subcutaneous tissues. Initial urgent management of NSTIs re...

pmc.ncbi.nlm.nih.gov

Cellular elongation under the influence of antibacterial agents: way to differentiate coccobacilli from cocci

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