Effectiveness of different antibiotic lock solutions on catheter-related infections of hemodialysis patients: a systematic review and meta-analysis

Antibiotic lock therapy (ALT) delivers high‐concentration antimicrobials into catheter lumens and has been proposed to prevent infections in hemodialysis (HD) patients. We conducted a systematic revie...

pmc.ncbi.nlm.nih.gov

AGA Clinical Practice Update on Management of Clostridioides difficile Infection in Adults: Expert Review

Clostridioides difficile infection is a common cause of clinically significant diarrhea, often becomes recurrent, and can be fatal when severe or fulminant. The purpose of this America Gastroenterological Association (AGA) Clinical Practice Update Expert Review is to provide best practice advice for C difficile infection management.

cghjournal.org

A Structured Approach to Skin and Soft Tissue Infections (SSTIs) in an Ambulatory Setting

The skin is the largest, and arguably, the most vulnerable organ in the human body. Scratches and scrapes, bites and puncture wounds, impetigo and erysipelas—all these disruptions can lead to pain, sw...

pmc.ncbi.nlm.nih.gov

Examining the clinical course of genotype 1 chronic hepatitis C patients treated with the cosmos regimen: including patients with advanced liver disease and East Asian ancestry

The COSMOS study was a phase 2a clinical trial that showed high cure rates of genotype 1 chronic hepatitis C (CHC) and a favorable side effect profile using a 12-week regimen of simeprevir + sofosbuvi...

pmc.ncbi.nlm.nih.gov

Drug Triggers and Clinic of Acute Generalized Exanthematous Pustulosis (AGEP): A Literature Case Series of 297 Patients

Acute generalized exanthematous pustulosis (AGEP) is a rare skin reaction, commonly caused by drugs. Available evidence mostly relies on small studies or case reports. We collected published AGEP case...

pmc.ncbi.nlm.nih.gov

The First Chinese Edited Babies: A Leap of Faith in Science

pmc.ncbi.nlm.nih.gov

Continuous vs Intermittent β-Lactam Antibiotic Infusions in Critically Ill Patients With Sepsis

This clinical trial compares the efficacy of continuous vs intermittent infusion of a β-lactam antibiotic (piperacillin-tazobactam or meropenem) in decreasing all-cause mortality at 90 days in critica...

jamanetwork.com

Pre-emptive versus empirical antifungal therapy in patients with febrile neutropenia with acute leukaemia: a GIMEMA study

To compare the efficacy of pre-emptive antifungal therapy (PAT) and empirical antifungal therapy (EAT) in patients with febrile neutropenic acute leukaemia (AL) with/without anti-mold prophylaxis. We ...

pmc.ncbi.nlm.nih.gov

Serratia Infections: from Military Experiments to Current Practice | Clinical Microbiology Reviews

SUMMARY Serratia species, in particular Serratia marcescens, are significant human pathogens. S. marcescens has a long and interesting taxonomic, medical experimentation, military experimentation, an...

journals.asm.org

Prolonged oral vancomycin for secondary prophylaxis of relapsing Clostridium difficile infection - BMC Infectious Diseases

Background Clostridium difficile infection (CDI) is an important cause of diarrhea and continues to be a major burden within healthcare institutions and in the community. For a small subset of patient...

link.springer.com

The STROBE guidelines

An observational study is a type of epidemiological study design, which can take the form of a cohort, a case–control, or a cross-sectional study. When presenting observational studies in manuscripts,...

pmc.ncbi.nlm.nih.gov

Oral Lipid Nanocrystal Amphotericin B (MAT2203) for the Treatment of Invasive Fungal Infections

We report on 5 patients treated with MAT2203, an oral amphotericin-B formulation. MAT2203 was well tolerated and effectively treated deep tissue infections

academic.oup.com

mdpi.com

Ultra-long-acting cabotegravir could be taken three times a year for HIV PrEP and treatment

A longer-acting formulation of cabotegravir may offer an HIV pre-exposure prophylaxis (PrEP) and treatment option that could be administered once every four months, according to early study resul...

aidsmap.com

Neurocysticercosis: An Easy to Miss Diagnosis in Non-Endemic Regions

A 29-year-old male presented with swollen gums and stomatitis for the past two months. History revealed that he had moved to the United States from India six years ago and had a first episode of gener...

cureus.com

A Diagnostic Dilemma: Daptomycin-Induced Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Syndrome and Eosinophilic Pneumonia With Concurrent COVID-19

Adverse drug reactions are critical considerations in managing complex medical conditions. Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a rare but potentially life-threate...

cureus.com

Diagnostic Yield and Impact on Antimicrobial Management of 16S rRNA Testing of Clinical Specimens | Microbiology Spectrum

16S rRNA gene sequencing has been increasingly used in clinical practice. Using the final diagnosis as a gold standard, the sensitivity of 16S rRNA gene sequencing was fair. In the setting with no 16S...

journals.asm.org

Inappropriate Diagnosis of Pneumonia Among Hospitalized Adults

This cohort study characterizes inappropriate diagnosis of community-acquired pneumonia among hospitalized patients in 48 Michigan hospitals.

jamanetwork.com

Future of bNAbs in HIV Treatment - Current HIV/AIDS Reports

Purpose of Review Broadly neutralizing antibodies (bNAbs) represent a novel approach to HIV treatment, prevention, and cure strategies. As research advances, the clinical application of bNAbs continue...

link.springer.com

Frontiers | Diagnostic value and integrated threshold of ESR for diabetic foot osteomyelitis: a systemic review and meta-analysis

BackgroundDiabetic foot osteomyelitis (DFO) is a severe complication of diabetic foot infections (DFI). Early and accurate diagnosis is crucial for improving...

frontiersin.org

Pivmecillinam for Treatment of Uncomplicated Urinary Tract Infection: New Efficacy Analysis

In April 2024—over 40 years after its first approval in Europe—pivmecillinam received approval from the United States Food and Drug Administration (FDA) for the treatment of uncomplicated urinary trac...

pmc.ncbi.nlm.nih.gov

ClinicalKey

clinicalkey.com

sciencedirect.com

jppt.kglmeridian.com

pmc.ncbi.nlm.nih.gov

Beyond Susceptible and Resistant, Part I: Treatment of Infections Due to Gram-Negative Organisms With Inducible β-Lactamases

Inactivation of β-lactams by the action of β-lactamase enzymes is the most common mode of resistance to these drugs among Gram-negative organisms. The genomes of some key clinical pathogens such as En...

pmc.ncbi.nlm.nih.gov