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Liverpool Drug Interactions

@liverpoolddis.bsky.social

Updates from Liverpool HIV Drug Interactions, the globally recognised resource for free drug interaction information. Based at Centre for Experimental Therapeutics (TherEx), University of Liverpool. https://www.druginteractions.org/

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COVID-19 Drug Interactions@covidinteractions.bsky.social · 7mo ago

Still time to register for The Liverpool Course: COVID-19. We have a great programme lined up with fantastic speakers! Not to be missed! To register: www.covid19-druginteractions.org/site_news/237 #druginteractions #covid19 #DDIs #webinar

COVID-19 Drug Interactions@covidinteractions.bsky.social · 7mo ago

Join us online from 3PM GMT on Wednesday 18th February for The Liverpool Course: COVID-19! We have a great line-up of speakers and presentations focusing on the clinical management of DDIs in COVID-19. For more info and free registration 👉 www.covid19-druginteractions.org/site_news/237

HIV Drug Interactions@hivinteractions.bsky.social · 11mo ago

🎉 Exciting milestone on the HIV Drug Interactions website! We have passed 50,000 individual drug interactions published. This follows 15 new comedications added this month: Procainamide, Amoxapine, Methysergide, Perospirone, Sertindole, Secobarbital, Barnidipine, Nimodipine,Tropisetron... (1/2)

HIV Drug Interactions@hivinteractions.bsky.social · last yr.

💊 New comedications on the HIV website: Anaesthetics and Muscle Relaxants: Cyclobenzaprine Antibacterials: Gatifloxacin, Nafcillin, Neomycin, Roxithromycin Anticoagulants, Antiplatelets and Fibrinolytics: Nadroparin Anticonvulsants: Felbamate Antihistamines: Clemastine (1/2)

COVID-19 Drug Interactions@covidinteractions.bsky.social · last yr.

🚦Updates to Paxlovid interactions: 97 yellow interactions with 5-day administration reviewed, 9 changed to 🟢GREEN, 3 changed to 🟠AMBER, and 85 kept as 🟡YELLOW with the additional comment that “coadministration has not been studied, but can be considered”.

Screenshot of yellow summary of Paxlovid (5 days) with ethinylestradiol. Summary reads: Coadministration has not been studied but can be considered. Ethinylestradiol is metabolized by hydroxylation and glucuronidation. When used in a combined pill, ethinylestradiol is expected to be reduced. This is unlikely to impair contraceptive efficacy, particularly considering the short duration of nirmatrelvir/ritonavir treatment, though it may increase the risk of irregular bleeding. However, it should be noted that the Paxlovid product labels state patients using combined hormonal contraceptives should be advised to use an effective alternative contraceptive method or an additional barrier method of contraception during treatment with nirmatrelvir/ritonavir, and until one menstrual cycle after stopping nirmatrelvir/ritonavir.