Barbara Pistilli

@barbarapistill2.bsky.social

Medical Oncologist, Head of Breast Cancer Unit, Gustave Roussy, France

ADC (in)stabilities: - Both sacituzumab govitecan (SG) and sacituzumab tirumotecan (sac-TMT) have an unstable carbonate linker (half-life ~24 h) that releases their respective payloads over time - SG has an additional point of instability (thiol-maleimide conjugation) Get ready for #SABCS24

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Raffaele Colombo@raffcolo.bsky.social · 2y ago

ADC trivia: what’s the linker stability of the newly approved (by Chinese NMPA) sacituzumab tirumotecan? 1, 2, 3, 4, 5, 6, 7, or 8? For more info on ADC linker (in)stabilities: aacrjournals.org/cancerdiscov...