🚨 PhD opportunity at @ccg-ucl.bsky.social! Build AI & computational tools to catch ecDNA in single cells: rogue DNA circles that let cancer beat therapy With @jamal-hanjani-lab.bsky.social & @benjaminwerner.bsky.social Black Leaders in Cancer PhD at UCL CI 👇 www.colcc.ac.uk/2027-blic-ph...

2027 BLiC PhD project Zaccaria

Computational single-cell investigation of extrachromosomal DNA and replication-timing alterations shaping metastatic cancer Primary supervisor: Simone Zaccaria, UCL Secondary supervisors: Benjamin Werner, Queen Mary University of London; Mariam Jamal-Hanjani, UCL Project High-level copy-number amplification of oncogenes is a common mechanism of cancer activation and a major source of intratumoural heterogeneity, poor outcomes, and treatment resistance .

colcc.ac.uk

Cancer Research UK City of London Centre@cruk-cityoflondon.bsky.social · 3w ago

Are you interested in doing a #PhD in #cancerresearch? 🧪👩🏿‍🔬🧫🦠🔬 Do you want to develop new #biotherapeutics? Are you of black heritage? Applications for our fully funded 4-year BLiC PhD programme starting in Autumn 2027 are open now! www.colcc.ac.uk/black-leader... #BlackLeadersinCancer #CRUK

Through the integration of the #PEACE autopsy programme, which allows high breadth metastasis sampling, with the #TRACERx lung study, we collected and studied 501 primary and metastatic tumour samples from 24 patients with non-small cell lung cancer (NSCLC) enrolled in the both studies. 2/9

Using MACHINA from @braphael.bsky.social's lab to infer metastatic migration patterns, we found that NSCLC primaries had multiple seeding subclones more often than a single seeding subclone. 4/9

Excited to share our ‘Evolutionary characterization of lung cancer metastasis’ in #TRACERx & #PEACE, published today in @nature.com in collaboration with @charlesswanton.bsky.social @nickymcgranahan.bsky.social @zaccasimo.bsky.social at @ucl.ac.uk & @crick.ac.uk. www.nature.com/articles/s41...

Evolutionary characterization of lung cancer metastasis - Nature

DNA-sequencing data from primary tumours and paired metastases from participants in the TRACERx lung study and PEACE autopsy programme are used to analyse the metastatic diversity of advanced non-smal...

nature.com

🚨 Huge honour to have helped supervise this landmark PEACE study! New insights into metastasis + a unique dataset of unprecedented resolution on metastatic evolution and dissemination that we hope will drive future advances. 🙏 @cancerresearchuk.org @uclhresearch.bsky.social Please take a look 👇

Jamal-Hanjani Lab@jamal-hanjani-lab.bsky.social · 6mo ago

Excited to share our ‘Evolutionary characterization of lung cancer metastasis’ in #TRACERx & #PEACE, published today in @nature.com in collaboration with @charlesswanton.bsky.social @nickymcgranahan.bsky.social @zaccasimo.bsky.social at @ucl.ac.uk & @crick.ac.uk. www.nature.com/articles/s41...

1 in 2 people will get cancer in their lifetime. Our team'll still run @cancerresearchuk.org Muddy Race also this May to highlight the importance of funding cancer research and improving patient outcomes Please support us if you can! #RaceforLife 👉 fundraise.cancerresearchuk.org/team/computa...

Computational Cancer Genomics (CCG) Research Group

We are the Computational Cancer Genomics (CCG) Lab at the UCL Cancer Institute, a group of passionate scientists and clinicians who work on developing computational methods to unravel cancer's mysteri...

fundraise.cancerresearchuk.org