Alexandre Baffet
@alexbaffet.bsky.social
Cell Biologist studying neurogenesis and neural stem cells using live imaging methods. INSERM investigator. Group leader @institut_curie Paris.
🔥🔥🔥 New preprint! Our new work explores the dynamic behaviour of muscle stem cells and their niche interactions in Duchenne Muscular Dystrophy. www.biorxiv.org/content/10.1... #MyoBlue
Impaired stem cell migration and divisions in Duchenne Muscular Dystrophy revealed by live imaging
Dysregulation of stem cell properties is a hallmark of many pathologies, but the dynamic behaviour of stem cells in their microenvironment during disease progression remains poorly understood. Using t...
biorxiv.org
💫 New preprint from the lab: Comparing great ape cerebral organoids, we found that human-specific morphoregulatory signatures in basal radial glia characterise neocortex evolution. Fantastic work from super-talented PhD student Theresa Schütze! www.biorxiv.org/content/10.1...
Brain cancer leverages the same tools as the developing brain 🧠! In our new study from the Kriegstein and Li labs, published today in @nature.com, we mapped neocortical development to explore brain cancer and neuropsychiatric risks. #stemcells #brainresearch www.nature.com/articles/s41...
Molecular and cellular dynamics of the developing human neocortex - Nature
Tripotential intermediate progenitor cells are responsible for the local production of GABAergic neurons, oligodendrocyte precursor cells and astrocytes in the human neocortex.
nature.com
Our new paper is out in BioRxiv. Using human fetal tissue and cortical organoids, we figured out how human bRG cells colonize the developing neocortex to expand the oSVZ stem cell niche. Turns out, it's a more complex process than we had anticipated! www.biorxiv.org/content/10.1...