Here is my colleague Adam Riess, Nobel laureate, sharing his thoughts on advocating for science at a recent event at the US Capitol. aas.org/posts/news/2...

1/10 Our latest research, led by @martijnselten.bsky.social, identifies a mechanism through which Parvalbumin (PV) interneurons regulate their activity in the #cortex. This is the story @nature.com www.nature.com/articles/s41... ⬇︎ 🧵 @devneuro.bsky.social @kingsioppn.bsky.social @erc.europa.eu

President Donald Trump today asked Congress to make massive and unprecedented cuts to the 2026 budgets of major federal science agencies. scim.ag/3Yszqnm

Trump’s proposed budget would mean ‘disastrous’ cuts to science

Key research budgets would shrink by one-third to one-half in 2026 spending plan

scim.ag

The president is recommending a 40% cut to next year’s NIH budget. This would be disastrous for our nation’s health and economy. Please contact your representatives, especially if they are Republicans, and tell them why this cannot happen. An easy option: 5calls.org

5 Calls

Spend 5 minutes. Make 5 calls. Make your voice heard.

5calls.org

Richard Van Noorden@richvn.bsky.social · last yr.

Trump proposes unprecedented budget cuts for US science in next fiscal year NASA cut by 24% NIH cut by 40% EPA cut by 55% NSF cut by 56% Analysis from @maxkozlov.bsky.social @dangaristo.bsky.social @alexwitze.bsky.social and @nature.com team www.nature.com/articles/d41...

Effective immediately, the government says it will begin screening immigrant social media for activity that officials think indicates support for antisemitism.

U.S. says it is now monitoring immigrants' social media for antisemitism

Effective immediately, the government says it will begin screening immigrant social media for activity that officials think indicates support for antisemitism.

npr.org

Orderly specification and precise laminar deployment of mouse cortical projection neuron types through intermediate progenitors. www.cell.com/developmenta...

Orderly specification and precise laminar deployment of mouse cortical projection neuron types through intermediate progenitors

Inside-out laminar patterning is a fundamental mechanism in cortical neurogenesis, but sequential specification and precise laminar deployment of projection-defined excitatory neuron types also arises...

cell.com

This a sign of the dark times in which we live & I'm not bragging about it. My team posted an open position for an industry research scientist and we got 20 times the response rate in the 1st week we normally would & the seniority of the applicants was way higher than the norm. All from academia.

High-throughput single cell -omics using semi-permeable capsules https://www.biorxiv.org/content/10.1101/2025.03.14.642805v1

How does the #vasculature regulate #immune cell infiltration & function across different brain tumors? 🧠🧪 Excited to share our latest study in #Immunity where we uncover some interesting answers— led by the amazing @lbejarano.bsky.social 🤩👏🏻 🧵 @cp-immunity.bsky.social www.cell.com/immunity/ful...

Spatial transcriptomics holds great promise to understand biological tissue function, but the assignment of transcripts to cells has been a substantial bottleneck. For this reason, Elyas Heidari, a student in my lab and in @steglelab.bsky.social built segger. www.biorxiv.org/content/10.1...

“Nobody feels like their job is safe. Everyone is on edge,” said Kim Hasenkrug, an NIH scientist emeritus… “Even the top people can’t keep track because they’re hiring and firing so much. Direct supervisors of those who were terminated didn’t even know that it was happening.”

At NIH, ‘everyone is on edge’ as they brace for deep cuts and more centralized control

As the NIH braces for cuts of up to 5,000 of its 20,000 positions, “people are scrambling and freaking out,” a researcher said.

statnews.com

Wow this is a game changer. PhD scholarships and postdoctoral fellowships are now open to non-Canadians.

Dr Dan Shugar 🇨🇦@watershedlab.bsky.social · 2y ago

🚨 HUGE news from Canada's tricouncils who are harmonizing their scholarship & fellowship programs, upping the total number (huzzah!), and critically, allowing foreigners to apply for doctoral and postdoc fellowships. Want to work with me? Get in touch! 🇨🇦🧪⚒️ www.nserc-crsng.gc.ca/NewsDetail-D...

The Trump administration has terminated $800 million in grants to Johns Hopkins University, spurring the nation’s top spender on research and development to plan layoffs and cancel health projects

Johns Hopkins Plans Staff Layoffs After $800 Million Grant Cuts

Local and international health research efforts are already winding down as the university braces for even more potential cuts.

wsj.com

After last week publication from the lab on circuits of social isolation/satiety, today we publish a different line of research by @harriskaplan.bsky.social et al., on the development trajectories of hypothalamic POA cell types driving survival and social behavior. www.nature.com/articles/s41...

Sensory input, sex and function shape hypothalamic cell type development - Nature

Paired transcriptomic and chromatin accessibility profiling are used to examine the developmental trajectories of neuronal populations in the hypothalamic preoptic region, including cell types with ke...

nature.com

🧪 This study highlights why we should not focus so much on genetic factors or drug targets. The #exposome (environmental exposures) has greater impact on disease patterns and premature mortality than genetic factors. www.nature.com/articles/s41... #planetaryhealth #academicsky #medsky #idsky

Integrating the environmental and genetic architectures of aging and mortality - Nature Medicine

Based on a systematic analysis of environmental exposures associated with aging and mortality in the UK Biobank, the relative contributions of such exposures and genetic risk for mortality and a range...

nature.com

✨ We tend to think of species-specific differences as resulting from the presence of species-specific genes. In our latest work with @djabaudon.bsky.social, we show that building brains is not only about which genes you use, but also about when and where you do. www.biorxiv.org/content/10.1...

It’s @katherinejwu.com with the receipts. The NIH memo undercutting the NIH came directly from Trump officials. www.theatlantic.com/health/archi...

The NIH Memo That Undercut Universities Came Directly From Trump Officials

NIH officials said they were given no advance warning and less than an hour to post the memo publicly.

theatlantic.com

One of the coolest and most novel findings I’ve seen in years. This is why I work in worms. To find things no one even really knew to look for. Like a conserved system that splices transposons out of mRNAs to prevent otherwise lethal insertions in essential genes! - www.biorxiv.org/content/10.1...

An RNA Splicing System that Excises Transposons from Animal mRNAs

All genomes harbor mobile genetic parasites called transposable elements (TEs). Here we describe a system, which we term SOS splicing, that protects C. elegans and human genes from DNA transposon-medi...

biorxiv.org

🔈We've got the cover of the 2nd NG issue for 2025🙌 Read about the cover: In the comment👇 Also check out our research briefing🚨 (link below): nature.com/articles/s41... nature.com/articles/s41...

The no cost extension button is back and at least some are being granted. If this applies to you, go for it. PLEASE SHARE

a man in a suit and tie says go for it in white letters

ALT: a man in a suit and tie says go for it in white letters

media.tenor.com

Another crazed change from the Trump Administration: removing the NIH No-cost extension form

Do psychiatric GWASs find drug targets? Excited to see our work linking GWAS and pharmacological treatments in psychiatric disorders now published in JAMA Psychiatry jamanetwork.com/journals/jam... 🧬💊🎯 Big thanks to @bendfulcher.bsky.social @alexfornito.bsky.social Mark Bellgrove 🧵👇

Today is Retraction Day, when we observe the anniversary of the retraction (Feb. 2, 2010) of the fraudulent paper that purported to show a link between vaccines and autism. 🧪#medsky

Now on BioRxiv: we explored patient-derived GBM organoids & spheroids generated from the same resected tissue. Critically, both models maintain tumor cell composition & heterogeneity, with comparable tissue resemblance across data modalities (1/4) www.biorxiv.org/content/10.1...

Our new paper is out in BioRxiv. Using human fetal tissue and cortical organoids, we figured out how human bRG cells colonize the developing neocortex to expand the oSVZ stem cell niche. Turns out, it's a more complex process than we had anticipated! www.biorxiv.org/content/10.1...

Excellent work by @liwangneuro.bsky.social Arnold Kriegstein and colleagues, deepening our understanding of the molecular and cellular dynamics of the developing human neocortex. The identification of a tripotential intermediate progenitor subtype is a key finding 🧪🧠🧬 www.nature.com/articles/s41...

Molecular and cellular dynamics of the developing human neocortex - Nature

Tripotential intermediate progenitor cells are responsible for the local production of GABAergic neurons, oligodendrocyte precursor cells and astrocytes in the human neocortex.

nature.com

Brain cancer leverages the same tools as the developing brain 🧠! In our new study from the Kriegstein and Li labs, published today in @nature.com, we mapped neocortical development to explore brain cancer and neuropsychiatric risks. #stemcells #brainresearch www.nature.com/articles/s41...

Molecular and cellular dynamics of the developing human neocortex - Nature

Tripotential intermediate progenitor cells are responsible for the local production of GABAergic neurons, oligodendrocyte precursor cells and astrocytes in the human neocortex.

nature.com

Many academics point to bioRxiv as “the one thing improving science publishing”. If so, the one thing you all can do is persuade colleagues to submit and make this a norm. 1/2

We are recruiting a postdoc! Have expertise in RNA biology and want to apply it to neuro and neurodev disorders? Then apply 👇🏼 📌 $73,588 💰 📌 access to postdoc housing 🏠 📌 Support for internationals 🌍 📌 Awesome view 😅 🙏 RT labs.icahn.mssm.edu/derubeislab/...

Wow, there's a lot of us here now. Reintroducing myself: I am Joel 👋🏿. My lab studies how the microbiome shapes the immune system in health & disease, using a mix of bench and computational approaches. I am also passionate about mentoring the next generation of scientists 🥼. #immunology #microbiome