How do #malaria parasites know when human host conditions turn hostile and ‘decide’ to transmit to the mosquito? 🦟 Our new paper in @natmicrobiol.nature.com uncovers the molecular mechanism behind stress-induced sexual conversion in malaria parasites @isglobal.org 👇 www.nature.com/articles/s41...

AP2-HS and a GDV1 regulatory feedback loop mediate environmental induction of sexual conversion in Plasmodium falciparum - Nature Microbiology

This study describes the complex transcriptional regulatory mechanism enabling fine-tuned and rapid regulation of Plasmodium falciparum investment in transmission under changing blood conditions.

nature.com

🦟🌡️ Could fever help slow #malaria transmission? A study led by #ISGlobal suggests that the high temperatures caused by fever may temporarily reduce the malaria parasite's ability to be transmitted to mosquitoes. 🔗 https://shorturl.at/XB3in

#Plasmodium falciparum has a peculiar heat-shock response that depends on the AP2-HS transcription factor. If you ever wondered which conditions can turn it on, please have a look at our new article in PLoS Pathogens! 🔥🧬 journals.plos.org/plospathogen...

Characterisation of the thermal and non-thermal stress conditions that activate the Plasmodium falciparum AP2-HS-dependent heat-shock response

Author summary The most common clinical symptom of malaria is periodic fever. To survive at febrile temperatures, malaria parasites must protect themselves from the damage that these temperatures prod...

journals.plos.org

New preprint out! We made a #Plasmodium knowlesi A1-H.1 #transcriptome time course for asexual blood stages🩸. tinyurl.com/mwd9b8vx 👩‍💻Webtool to compare temporal expression to P. vivax: tinyurl.com/bdz2ndsj @itmantwerp.bsky.social @eknuepfer.bsky.social @cortesmalaria.bsky.social

It’s beginning to look a lot like Christmas! 🎵 Merry Christmas and happy holidays to everyone! 🎄🎁🍾 The Epis send you warm holiday wishes from our brand-new lab location @www.pcb.ub.edu ✨✨✨

Curious about which thermal 🌡️and non-thermal 💊conditions activate the AP2-HS-dependent heat-shock response in Plasmodium falciparum? Check out our new preprint in Biorxiv!📊🧪 www.biorxiv.org/content/10.1...

Thermal and non-thermal stress conditions activate the Plasmodium falciparum AP2-HS-dependent heat-shock response

To preserve proteome homeostasis and survive at higher-than-optimal temperatures, organisms have evolved the conserved heat shock (HS) response (HSR), characterised by increased expression of specific...

biorxiv.org

📣Rush to read our latest paper!! journals.plos.org/plospathogen.... You'll learn why #heterochromatin is formed and maintained in specific regions of the Plasmodium falciparum genome and not others 🧵⬇️

Heterochromatin de novo formation and maintenance in Plasmodium falciparum

Author summary Proper regulation of gene expression is crucial for the functioning of all organisms. One key mechanism involves modifications in the structure of chromatin, the DNA and proteins comple...

journals.plos.org

Our colleagues and us have been abducted from the lab!!! 🆘👽 If you see these ISGlobaliens around Barcelona, don't be shy and ask for a ride in their fantastic UFO! 🤩🛸

📣📣See our new preprint in Biorxiv, in which we explore the role of the primary DNA sequence 🧬 in de novo heterochromatin formation and maintenance 🔍📊🧩 www.biorxiv.org/content/10.1...

Heterochromatin de novo formation and maintenance in P. falciparum

In the malaria parasite Plasmodium falciparum, the expression of many genes is regulated by heterochromatin (HC) based on the histone mark tri-methylation of histone H3 lysine 9 (H3K9me3). HC assembly...

biorxiv.org

Welcome to our new Bluesky account!!👋😊Lots of science and fun ahead! 🔬🧪🥼🤩