Michael Fisch MD MPH
@fischmd.bsky.social
Medical oncologist and palliative care physician. Avid sports fan, experienced in baseball analogy use. Senior medical director for Carelon and clinical professor (part-time) in general oncology at MD Anderson Cancer Center
SWOG 2210 is open for #prostatecancer patients w/ BRCA1 or BRCA2. Fascinating to see BRCA’s role in other cancers. Hoping we see biomarkers unlock clues in RCC soon. #GUonc #oncsky #cansky
So thrilled to be joined by @missmeganel.bsky.social to discuss her amazing essay “Tamales” in our latest @ascocancer.bsky.social #CancerStories podcast! Listen to how patients invite their doctors into their culture and their world. 🎗️♥️🇲🇽 ascopubs.org/do/tamales-cel…
"If palliative care clinicians walk the line between security and vulnerability, then they must expect to misstep sometimes." This Viewpoint explores why palliative care clinicians may be at increased risk for dismissal. #MedSky https://ja.ma/42bomND
Why Good Palliative Care Clinicians Get Fired
This Viewpoint discusses why palliative care clinicians may be fired despite good job performance.
ja.ma
Clinician researchers should just remove the work "trend" from your vocabulary. Seriously! 😜 If what you are indicating by using that word is actually important, you will be able to find another way to describe it. I promise.
A brief plea to call a spade a spade (or more specifically, call a phase 1 a phase 1; a phase 2 a phase 2; a phase 3 a phase 3). www.europeanurology.com/article/S030...
The Importance of Precise Scientific Communication: Nonrandomized Trials Should Not Be Described as Phase 3, and Registrational-intent Trials Should Not Be Described as Phase 2
Standardized nomenclature for clinical trials is required so that the terms phase 1 (first-in-human dose-finding trials), phase 2 (trials to determine the safety and efficacy of a drug and the value o...
europeanurology.com
Cancer-Related Cognitive Impairment: A Practical Guide for Oncologists | JCO Oncology Practice ascopubs.org/doi/10.1200/...
Cancer-Related Cognitive Impairment: A Practical Guide for Oncologists | JCO Oncology Practice
ascopubs.org
Resilience and the Fallacy of “One Size Fits All.” www.nejm.org/doi/abs/10.1... @nejm.org @harvardmed.bsky.social @danafarber.bsky.social #PallOnc #GeriOnc #PalliativeCare
@fumikochino.bsky.social published in @ascocancer.bsky.social this important #pallonc study #Fintox 💰 is direct costs (e.g., copays) ➕ indirect costs (e.g., lost income) ➡️: ⬆️stress and skipping #cancer meds. 4 step #COST frame work ⬆️🗣️ 🔗: ascopubs.org/doi/10.1200/...
At some point the US will need to consider value when approving drugs (or at least deciding if we are going to pay for them).
Diane E Meier@dianeemeier.bsky.social · last yr.re: cancer label for lo-risk cancer: either a) relabel "but ensure patients understand [need for] monitoring" or b) don't relabel "but ensure patients understand lesions are unlikely to cause problems, so surveillance is appropriate." We know a) works better then b). jamanetwork.com/journals/jam...
Will Renaming Some Cancers as Noncancers Hurt or Help?
This Medical News article discusses the ongoing debate about whether the word cancer should be dropped from the names of indolent tumors of the prostate and breast.
jamanetwork.com
Cancer affects all in some way. Change is coming after too brief a period of great leadership by Dr. Kimryn Rathmell. Whatever happens it is an honor to express a vision for the field of cancer research & innovation in oncology. Research on causes & cures brings hope for patients.
I, too, have been surprised by the rise of "tornado plots" to plot clinical trial AEs at our conferences! 100% agree with ⬆️ this simple data vis change to improve interpretability of AEs.
Jack West, MD, FASCO@jackwestmd.bsky.social · 2y agoI think a tweak to show the bars next to each other, in the same direction rather than in opposite directions would make it far easier to compare diffs between results from groups. Isn't the version on the R easier to show where diffs in AEs exist? IMO, we should do this variant instead. (5/8)
#ESMOImmuno24 Proffered paper🔥 Ph III CM73L: Nivo+cCRT➡️consol Nivo/Ipi v Nivo v cCRT➡️Durva @solangepeters.bsky.social - no PFS/OS benefit - g3+TRAE 57%, 54%, 49% - concerning pneumonitis signal Concurrent RT+IO - going going gone @oncoalert.bsky.social #LCSM #Medsky #Oncsky
1/4 @swog.org lung cancer trial, PRAGMATICA, closes early! This randomized trial enrolled 800 volunteers w stage 3-4 lung cancer in 21 months (goal was 700 in 24m). Tested chemo vs ramicirumab/pembrolizumab. Not applicable to every trial, but...
Hot of the press from @proteuspros - an infographic explaining the value of PROs! Note - they need to start as parr of the clinical encounter to benefit patients and society. tinyurl.com/3m594fhk
Remote Symptom Monitoring of Patients With Advanced Lung #Cancer (The ProWide Study): A Randomized Controlled Trial. ascopubs.org/doi/10.1200/... @ascopost.bsky.social #LungCancer #PallOnc #SuppOnc
De-escalation discussion on Europa trial tag line - which would you prefer, 5 days of RT or 5 years of ET…. 🤔🤔 No-brainer?? Supported by BASO II trial longer term data #SABC24
This is great because patients hate endocrine therapy! However, we need to see recurrence data before adopting in the clinic. #BCSM #SABCS24
Elisabetta Bonzano MD, PhD@elisabettabonzano.bsky.social · 2y ago📌 EUROPA Trial: Exclusive Endocrine Therapy or Radiation Therapy in Women Aged 70+ Years with Luminal-Like Early Breast Cancer: Preplanned Interim Analysis of a Randomized Phase 3 Trial @icromeattini.bsky.social 👏🏻👏🏻👏🏻 doi.org/10.1016/S147... #SABCS24 #GeneralSession2 #Day3 @oncoalert.bsky.social
#SABCS24 #bcsm #OncSky #RadOnc #MedSky BIG 2-04 SUPREMO: postmastectomy #radiation in int risk #breastcancer did not improve 10y overall survival, incl for node + subset. Stat sig but small ⬇️ in chest wall recurrence (2.5% -> 1.1% abs risk, NNT 63 to prevent 1 CW recurrence) @oncoalert.bsky.social
Omission of Axillary surgery continues to build momentum Here in pts w/ cN0 T1-2 invasive breast cancer—omission is noninferior to SLNB w 6 years med f/u Axillary Surgery in Breast Cancer — Primary Results of the INSEMA Trial www.nejm.org/doi/full/10.... #SABCS24 @oncoalert.bsky.social @nejm.org
Axillary Surgery in Breast Cancer — Primary Results of the INSEMA Trial | NEJM
Whether surgical axillary staging as part of breast-conserving therapy can be omitted without compromising survival has remained unclear. In this prospective, randomized, noninferiority trial, we i...
nejm.org
Dr. Singh draws nice comparisons between SOUND and INSEMA. #SABCS24 @oncoalert.bsky.social @sabcs.bsky.social
It's a difficult topic to discuss- weight. Hugely personal, not easy to change, but impt. 4% ⬆️ recurrence in pts w/ node + #bcsm obese vs. lean 2% ⬆️ recurrence in pts with N0 dz 📌Magnitude of effect larger among premeno. 📌ER + AND ER neg @sabcs.bsky.social #SABCS24 @oncoalert.bsky.social
📌 PATINA: a Randomized, Open Label, Phase III Trial to Evaluate the Efficacy and Safety of Palbociclib + Anti-HER2 Therapy + ET vs. Anti-HER2 Therapy + ET after Induction Treatment for Hormone Receptor-Positive (HR+)/HER-Positive Metastatic Breast Cancer #SABCS24 #day3 @oncoalert.bsky.social
Better together- very excited about this @swog.org @alliancenctn.org #CTIU collaboration 🤝
SWOG Cancer Research Network@swog.org · 2y agoNew Trial Alert! The PROSPECT-Lung trial is a new @NCI study looking to improve treatment for patients with #lungcancer. Researchers aim to explore new ways to enhance survival rates & quality of life. Learn more, visit bit.ly/PROSPECTLung #NCI #NCTN #LCsm AllianceNCTN.org @swog.org
I never tire of seeing these progressively improved pediatric ALL survival curves, which represent one of the most remarkable achievements in all of medicine. Amazing to see even more improvement with bispecific antibody #immunotherapy presented in the #ASH24 Plenary session. #hematology #leukemia
