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Yannick Brägger

@ybraegger.bsky.social

SNSF Postdoctoral Fellow at Princeton University

2 Posts54 Follower 102 Folgt

Yannick Brägger @ybraegger.bsky.social · last mo.

Check out the next chapter on nitrogen atom insertion into unactivated alkenes! Here, we present a method that furnishes aza-allenium salts from allylic nucleophiles, furnishing 3-imidazolines & 3-oxazolines, which were previously not generally accessible. chemrxiv.org/doi/abs/10.2...

Modular synthesis of rare N-heterocycles by nitrogen insertion into allylic nucleophiles | ChemRxiv

N-Heterocycles are crucial targets in medicinal chemistry, agrochemistry, and materials science. Hence, the modular assembly of heterocyclic scaffolds through cyclization of linear precursors has been...

chemrxiv.org

Morandi Research Group @morandilab.bsky.social · last yr.

Congrats to Ann-Sophie Paschke, @ybraegger.bsky.social, Bence Botlik, Erich Staudinger, @origreen.bsky.social! "Carbon-to-nitrogen atom swap enables direct access to benzimidazoles from drug-like indoles". www.nature.com/articles/s41.... @natchem.nature.com.

Morandi Research Group @morandilab.bsky.social · last yr.

Congrats to @fruepp.bsky.social, Vasily Grebennikov, Mykola Avramenko, Marc-Olivier Ebert "Kinetic, Spectroscopic, and Computational Investigation of Oxidative Aminative Alkene Cleavage Reveals an N-Iodonium-Iminoiodinane Pathway" now @chemrxiv.org - chemrxiv.org/engage/chemr...

Edward Nirenberg @enirenberg.bsky.social · last yr.

Peter Marks’s resignation letter. Everyone should read this.

Peter Marks, MD, PhD
Director, Center for Biologics Evaluation and Research U.S. Food and Drug Administration
10903 New Hampshire Avenue
Silver Spring, MD 20903
March 28, 2025
Sara Brenner, MD, MPH
Acting Commissioner of Food and Drugs
U.S. Food and Drug Administration
10903 New Hampshire Avenue
Silver Spring, MD 20903
Dear Dr. Brenner:
It is with a heavy heart that I have decided to resign from FDA and retire from federal service as Director of the Center for Biologics Evaluation and Research effective April 5, 2025. I leave behind a staff of professionals who are undoubtedly the most devoted to protecting and promoting the public health of any group of people that I have encountered during my four decades working in the public and private sectors. I have always done my best to advocate for their well-being and I would ask that you do the same during this very difficult time during which their critical importance to the safety and security of our nation may be underappreciated.
Over the past years I have been involved in enhancing the safety of our nation's blood supply, in advancing the field of cell and gene therapy, and in responding to public health emergencies. In the last of these, during the COVID-19 pandemic I had the privilege of watching the vision that I conceived for Operation Warp Speed in March 2020 in collaboration with Dr. Robert Kadlec become a reality under the leadership of HHS Secretary Azar and President Trump due to the unwavering commitment of public servants at FDA and elsewhere across the government. At FDA, the tireless efforts of staff across the agency resulted in remarkably expediting the development of vaccines against the virus, meeting the standards for quality, safety, and effectiveness expected by the American public. The vaccines undoubtedly markedly reduced morbidity and mortality from COVID-19 in the United States and elsewhere. Many of these same individuals applied learnings from the pandemic during a flawless response helping…

Morandi Research Group @morandilab.bsky.social · 2y ago

Many Congrats to @ybraegger.bsky.social, Ann-Sophie Paschke, Nima Nasiri, Bence Botlik and Francesco Felician for this masterpiece! Oxidative amination by nitrogen atom insertion into carbon-carbon double bonds in Science, @ethzurich.bsky.social. www.science.org/doi/10.1126/...

Oxidative amination by nitrogen atom insertion into carbon-carbon double bonds

The synthesis of nitrogen-containing molecules through carbon–nitrogen (C–N) bond formation is critical for the discovery and preparation of medicines, agrochemicals, and materials. Here, we report th...

science.org

Yannick Brägger @ybraegger.bsky.social · 2y ago

Check out the final version of our paper on nitrogen atom insertion into unactivated alkenes, out now in @science.org! Many thanks to my amazing colleagues Ann-Sophie Paschke, Bence Béla Botlik, and former students Francesco Felician and Nima Nasiri! www.science.org/doi/10.1126/...

Oxidative amination by nitrogen atom insertion into carbon-carbon double bonds

science.org

Jake Yeston @jakeyeston.bsky.social · 2y ago

Also in @science.org for chemsky this week, we have two methods of turning olefins into nitriles, respectively from Bill Morandi's group and Ning Jiao's group 🧪 www.science.org/doi/10.1126/...

Oxidative amination by nitrogen atom insertion into carbon-carbon double bonds

science.org

Stefan P. Schmid @spschmid.bsky.social · 2y ago

🚀 Looking for reaction conditions that work well for multiple substrates? CurryBO can help🍛 Now out on arXiv: arxiv.org/abs/2502.18966 A short explanation thread 👇

One Set to Rule Them All: How to Obtain General Chemical Conditions via Bayesian Optimization over Curried Functions

General parameters are highly desirable in the natural sciences - e.g., chemical reaction conditions that enable high yields across a range of related transformations. This has a significant practical...

arxiv.org