Tessera
Folgen

McDevitt Laboratory

@mcdevittlab.bsky.social

The McDevitt lab studies bacterial pathogens, metals, transporters, and develops novel antibiotics. Based in @thedohertyinst.bsky.social at the @unimelb.bsky.social Lab head: @camcdevitt.bsky.social

3 Posts441 Follower458 Folgt
McDevitt Laboratory@mcdevittlab.bsky.social · 7mo ago

🚀 PhD Opportunity on Infectious Diseases and #AMR! 🧬🔬 Are you passionate about understanding how #bacteria acquire essential #biometals and cause disease? We have fully funded joint PhD project (@thedohertyinst.bsky.social) with Prof. Trevor Moraes (@utoronto.ca). To find out more: bit.ly/4pMfmI4

Molecular Insights into Emerging Determinants of Bacterial Zinc Homeostasis : Find an Expert : The University of Melbourne

<p> <em>Klebsiella pneumoniae</em> is a Gram-negative opportunistic pathogen and a World Health Organization (WHO) priority organism, owing to rising rates of multidrug resistance and the increasing burden of infections in both community and healthcare settings. These challenges, together with the lack of an effective vaccine, highlight an urgent need to identify new therapeutic targets for the treatment of <em>K. pneumoniae</em> infections. </p> <p> Zinc is an essential first-row transition metal ion required by all forms of life. In bacteria, zinc has critical roles in cellular physiology and virulence. This PhD project will employ state-of-the-art molecular, structural, and elemental analytical techniques to characterise newly identified systems involved in <em>K. pneumoniae</em> zinc acquisition and resistance. The project will examine how these systems contribute to evasion of host innate immune responses and antimicrobial resistance. Insights gained from this work will provide a strong foundation for the development of novel therapeutics targeting bacterial metal homeostasis pathways. </p>

bit.ly

Christopher McDevitt@camcdevitt.bsky.social · 8mo ago

Thrilled to announce a new @natcomms.nature.com paper led by Alastair Stewart and team @victorchang.edu.au with contributions from @mcdevittlab.bsky.social Using #cryoEM we discovered unique features of the #Pseudomonas aeruginosa ATP synthase including an unexpected role for #zinc in the complex 🦠🔬

Distinct structural features of Pseudomonas aeruginosa ATP synthase revealed by cryo-electron microscopy - Nature Communications

ATP synthase powers cells by converting proton translocation into energy. Here, authors reveal distinct structural features of the P. aeruginosa ATP synthase that regulate activity and may serve as ta...

doi.org

McDevitt Laboratory@mcdevittlab.bsky.social · 11mo ago

🚀 Proud McDevitt Team #student achievements! 🌟 🎉 Salma smashed the #UniMelb #3MT 🏆 🎉 Abigail nailed the #Doherty Symposium Poster Award 🏅 🔥 These two are unstoppable! #PhDlife #Research #AcademicTwitter

Christopher McDevitt@camcdevitt.bsky.social · 11mo ago

Proud #supervisor announcements! Congratulations to two of my brilliant PhD students 🌟 🥳 Huge congrats to Salma Naleem for winning the University of Melbourne 3 Minute Thesis competition, and Abigail Hartono for winning the Graduate Student Poster Award at the Doherty Symposium! 🔥 You’re both stars!

Salma Naleem receiving a trophy and flowers
Christopher McDevitt@camcdevitt.bsky.social · last yr.

The costs of #antimicrobial resistance 🦠 continue to rise 📈. The Center for Global Development reports that by 2050 #AMR could shrink the global economy by US$1.7T. Improving treatments and funding development of new antimicrobials 💊 could save millions of lives and billions in healthcare costs.

Forecasting the Fallout from AMR: Economic Impacts of Antimicrobial Resistance in Humans

Antimicrobial resistance (AMR) is a growing global health crisis that threatens to undo decades of progress in medicine. This tool allows you to explore the potential impact of different interventions...

cgdev.org