✨ New C-GEM preprint E. coli ribosomes support translation of (R) and (S) β2-hydroxyacids in vitro: a structural and biochemical study Congrats @c-majumdar.bsky.social, @alexandra-kent.bsky.social, @nxhamlish.bsky.social, Cathy, Katie, Alanna, and @jhdcate.bsky.social! chemrxiv.org/engage/chemr...

Escherichia coli ribosomes support translation of (R) and (S) β2-hydroxyacids in vitro: a structural and biochemical study

The ribosomal incorporation of backbone-modified amino acid analogs into peptides and proteins enables the programmed synthesis of sequence-defined biopolymers with tunable properties. However, the su...

chemrxiv.org

Feels hard to write about anything other than *gestures broadly* but I did just finish the roll of parafilm I bought at the start of my PhD. Can I redeem this for a fun shirt or a donut?

✨ New from C-GEM in ACS Central Science: Thioesters Support Efficient Protein Biosynthesis by the Ribosome pubs.acs.org/doi/10.1021/... Congrats to Alexandra & Jacob, along with Isaac, Jess, @alexsolivan.bsky.social, @nxhamlish.bsky.social, Katie, Alanna, Jamie, and Scott! #NSFfunded @pubs.acs.org

Thioesters Support Efficient Protein Biosynthesis by the Ribosome

Thioesters are critical chemical intermediates in numerous extant biochemical reactions and are invoked as key reagents during prebiotic peptide synthesis on an evolving Earth. Here we asked if a thio...

pubs.acs.org

I'm gonna be co-op-ing with the chemical biotechnologies group at Merck this summer and early fall! Really excited for this opportunity and grateful for all the people who helped make this possible If youre in NYC, hit me up to discuss protein engineering, synbio, and genetic code expansion!

📰 New from C-GEM in ACS Central Science! An exciting collaboration with our friends at Amgen and Schrödinger to demonstrate incorporation of multiple extended backbones in a protein in vivo ✨ Congrats to @nxhamlish.bsky.social and the rest of the team! #NSFfunded pubs.acs.org/doi/10.1021/...

Incorporation of Multiple β<sup>2</sup>-Hydroxy Acids into a Protein <italic toggle="yes">In Vivo</italic> Using an Orthogonal Aminoacyl-tRNA Synthetase

The programmed synthesis of sequence-defined biomaterials whose monomer backbones diverge from those of canonical α-amino acids represents the next frontier in protein and biomaterial evolution. Such ...

pubs.acs.org