C9orf72 mutations impair immune activation in ALS, highlighting key differences in the cellular and molecular pathways underlying sporadic and genetics forms of the disease @mancusorenzo.bsky.social @c9laura72.bsky.social @baukje-bij.bsky.social @cmn-vib.bsky.social www.nature.com/articles/s41...

C9orf72 hexanucleotide repeat expansions impair microglial response in ALS - Nature Neuroscience

This study shows that C9orf72 mutations impair immune activation in ALS, affecting how brain cells communicate, and highlights key differences in the cellular and molecular pathways underlying sporadi...

nature.com

This weekend, our teams @cmn-vib.bsky.social & our amazing lab are trading lab coats for running shoes! We're hitting the pavement to raise funds for Alzheimer's research — a cause close to our hearts and minds. Every step we take brings us closer to a cure. StopAlzheimer

Thrilled to share our latest review in @natureneuro.bsky.social We dive into the transcriptional diversity of microglia across development, disease, regions, and sexes—highlighting emerging tools + a new resource for cell state annotation. @mancusorenzo.bsky.social @cmn-vib.bsky.social

Renzo Mancuso@mancusorenzo.bsky.social · last yr.

I am so excited to share our review on microglial heterogeneity @natureneuro.bsky.social! It was a fantastic effort by the lab, led by @c9laura72.bsky.social and Alma Mohebiany. We provide a critical view on the plethora of microglial cell states in health and disease. www.nature.com/articles/s41...

Laura Fumagalli (@mancusorenzo.bsky.sociallab) was recently awarded a pilot grant from Stichting Alzheimer Onderzoek. 🙌 This grant will support her research on the role of microglia in ALS and FTD. https://mancusolab.sites.vib.be/en/news#/news/the-other-side-of-c9orf72-what-happens-to-microglia

Congrats to Laura for obtaining a pilot grant from Stop Alzheimer! And thanks to Stop Alzheimer and all the donors for their incredible support to our research! @viblifesciences.bsky.social @uantwerpen.be stopalzheimer.be/nl/hoe-beinv...

Hoe beïnvloeden mutaties van het C9orf72-gen de hersenen? - Stop Alzheimer

Met dit onderzoek hoopt Fumagalli nieuwe therapeutische doelwitten te identificeren en bij te dragen aan verbeterde diagnostische en behandelingsmethoden voor FTD en ALS.

stopalzheimer.be