Onset of embryonic and placental defects coincide in 19 of 22 novel mid-gestation lethal murine knockout lines

Highlighted Article: A streamlined placental phenotyping pipeline involving histological and molecular analysis of early murine placental morphogenesis uncovers an underappreciated diversity of…

journals.biologists.com

Save the Date: ARRIGE Annual Conference 2026 | IMPC | International Mouse Phenotyping Consortium

“Who Gets to Edit the Future?” That’s the question ARRIGE’s Annual Conference 2026 will tackle this November, as we explore the governance of heritable genome editing in a multipolar world. 🗓️ 23–24 N...

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Searching for New Genes That Cause Usher Syndrome - PubMed

A screen of 9139 KO mouse lines revealed 18 candidate genes exhibiting both retinal and inner ear abnormalities consistent with the principal clinical features associated with USH. As the observed phenotypes are attributed to gene deletion in mice, these genes warrant further study to determine the …

pubmed.ncbi.nlm.nih.gov

SEARCHING FOR NEW GENES THAT CAUSE USHER SYNDROME - PubMed

A screen of 9,139 KO mouse lines revealed 18 candidate genes exhibiting both retinal and inner ear abnormality consistent with principle clinical features associated with USH. As the observed phenotypes are attributed to gene deletion in mice, these genes warrant further study to determine causation …

pubmed.ncbi.nlm.nih.gov

CRISPR knockout screens reveal genes and pathways essential for neuronal differentiation and implicate PEDS1 in neurodevelopment - Nature Neuroscience

We conducted a CRISPR screen to identify genes essential for neural differentiation. By integrating these findings with mouse neuroanatomy, we demonstrated its utility in discovering a new PEDS1-related neurodevelopmental disorder.

nature.com

IMPC Data Release 24 Now Available with over 4.5 Million Data Points  | IMPC | International Mouse Phenotyping Consortium

The IMPC is pleased to announce the launch of Data Release 24! With this latest release, we are now providing more than 138 million data points to the research community worldwide. This release includes phenotyping data for 9,605 genes from 10,341 mutant lines, adding approximately 4.5 million new data points. The total number of phenotype calls is 111,664 in this release.  As with every release, Data Release 24 not only […]

mousephenotype.org

Measuring the Scientific Impact of IMPC: How IMPC Resources Innovate Research   | IMPC | International Mouse Phenotyping Consortium

Over the years IMPC resources have contributed to numerous scientific publications including publications by the consortium members themselves as well as other researchers using IMPC generated mouse models and data. Tracking publication metrics can provide insights about the importance of IMPC as a resource as well as the wide range of research fields it contributes to.   Influence metrics tracked via NIH iCite show up until January 2026, IMPC has contributed to 8,423 peer-reviewed publications, showing […]

mousephenotype.org

Rare Disease Day 2026 | IMPC | International Mouse Phenotyping Consortium

Rare diseases are defined by their low prevalence — often fewer than 1 in 2,000 people — yet collectively affect hundreds of millions worldwide. These conditions are frequently genetic, complex, and under‑researched, with many patients facing long diagnostic journeys and limited treatment options. Rare Disease Day, observed every year on 28 February, raises global awareness of rare conditions and […]

mousephenotype.org

IMPC Images Now in Long-Term Image Archive | IMPC | International Mouse Phenotyping Consortium

The IMPC has collected over 850,000 images (DR23, April 2025) derived from systematic phenotyping of wild-type and mutant mouse lines. The collection spans multiple imaging modalities, including X-Ray, slit lamp eye imaging, Optical Coherence Tomography, light microscopy, microCT reconstructions of embryos, and histological sections, and has contributed to identification of candidate mouse models for more […]

mousephenotype.org

IMPC Images Now in Long-Term Image Archive | IMPC | International Mouse Phenotyping Consortium

The IMPC has collected over 850,000 images (DR23, April 2025) derived from systematic phenotyping of wild-type and mutant mouse lines. The collection spans multiple imaging modalities, including X-Ray, slit lamp eye imaging, Optical Coherence Tomography, light microscopy, microCT reconstructions of embryos, and histological sections, and has contributed to identification of candidate mouse models for more […]

mousephenotype.org

Identification of novel genes regulating the development of the palate

Background The International Mouse Phenotyping Consortium (IMPC) has generated thousands of knockout mouse lines, many of which exhibit embryonic or perinatal lethality. Using micro-computed…

anatomypubs.onlinelibrary.wiley.com

Endothelial RNF20 suppresses endothelial-to-mesenchymal transition and safeguards physiological angiocrine signaling to prevent congenital heart disease

Heart morphogenesis and function rely on intricate communication among distinct cardiac cell types. How their co-development and crosstalk are coordinated is largely unexplored. Our study unveils key functions of the histone H2B ubiquitin (H2Bub1) ...

pmc.ncbi.nlm.nih.gov

IMPC survey: Completing the catalogue of mammalian gene function and defining future priorities

IMPC is currently evaluating its future production and phenotyping priorities. To date, IMPC has focused on protein coding genes with human orthologs and little to no functional annotation, also referred to as “dark genes”. To date, the International Mouse Phenotyping Consortium- IMPC [which includes the NIH-funded Knockout Mouse Phenotyping Program (KOMP2)] has produced knockout mouse lines for 11,208 unique genes and conducted comprehensive phenotyping on 9,774 knockout lines, representing 9,073 genes. All data is accessible at www.mousephenotype.org and mice are available to order from public mouse repositories [e.g., Mutant Mouse Resource and Research Center (MMRRC)]. The purpose of this survey is to ascertain your level of interest and enthusiasm for IMPC to continue its production and phenotyping of knockout mouse lines for the remaining human orthologous genes in the mouse genome. In addition, this survey seeks your input on the scientific value of IMPC producing and phenotyping allele types other than knockouts. As a representative of your field of research, please consider and answer the following 9 questions…think broadly! Thank you for participating in this brief 10 minute survey.

docs.google.com

A New IMPC Paper Highlights Updates the Data Resource and Web Portal  | IMPC | International Mouse Phenotyping Consortium

A new consortium paper, ‘International Mouse Phenotyping Consortium Portal: facilitating investigation of gene function and providing insights into human disease’ by Wilson et al. (2025), published in Nucleic Acid Research, reports on the growth of the data resource and the improvements to the web portal. These changes allow for an easier use of the website […]

mousephenotype.org

IMPC survey: Completing the catalogue of mammalian gene function and defining future priorities

IMPC is currently evaluating its future production and phenotyping priorities. To date, IMPC has focused on protein coding genes with human orthologs and little to no functional annotation, also referred to as “dark genes”. To date, the International Mouse Phenotyping Consortium- IMPC [which includes the NIH-funded Knockout Mouse Phenotyping Program (KOMP2)] has produced knockout mouse lines for 11,208 unique genes and conducted comprehensive phenotyping on 9,774 knockout lines, representing 9,073 genes. All data is accessible at www.mousephenotype.org and mice are available to order from public mouse repositories [e.g., Mutant Mouse Resource and Research Center (MMRRC)]. The purpose of this survey is to ascertain your level of interest and enthusiasm for IMPC to continue its production and phenotyping of knockout mouse lines for the remaining human orthologous genes in the mouse genome. In addition, this survey seeks your input on the scientific value of IMPC producing and phenotyping allele types other than knockouts. As a representative of your field of research, please consider and answer the following 9 questions…think broadly! Thank you for participating in this brief 10 minute survey.

docs.google.com

MMRRC Repository

mmrrc.org

2025 ARRIGE Annual Meeting 28 & 29 October – ARRIGE

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Genome Browser Integration | IMPC | International Mouse Phenotyping Consortium

The introduction of a genome browser on the gene and allele pages enables visualisation of how IMPC alleles impact gene models. By default, this tool shows the curated RefSeq gene models, but optional...

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Training & Workshops | IMPC | International Mouse Phenotyping Consortium

Training Workshops

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Organoid News | Science News

Organoid News is an online resource dedicated to the latest research about and featuring organoids.

stemcellsciencenews.com

A graph theoretical approach to experimental prioritization in genome-scale investigations - Mammalian Genome

The goal of systems biology is to gain a network level understanding of how gene interactions influence biological states, and ultimately inform upon human disease. Given the scale and scope of system...

link.springer.com

We are co-organising Organoids Are Us 2025. Register now! | National Mouse Genetics Network

The MRC National Mouse Genetics Network, in collaboration with the Cancer Research UK (CRUK) Scotland Institute, is organising Organoids Are Us 2025, a symposium that incorporates both basic and clini...

nmgn.mrc.ukri.org